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6-amino-5-iodopyrimidin-2(1H)-one

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Identification
Molecular formula
C4H3IN3O
CAS number
183208-35-1
IUPAC name
6-amino-5-iodo-1H-pyrimidin-2-one
State
State

At room temperature, 6-amino-5-iodo-1H-pyrimidin-2-one exists in a solid state. It is stable under normal temperatures and pressures, though it should be stored in a cool, dry place for safety.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
495.00
Boiling point (Kelvin)
768.15
General information
Molecular weight
240.99g/mol
Molar mass
240.9860g/mol
Density
2.4500g/cm3
Appearence

6-Amino-5-iodo-1H-pyrimidin-2-one appears as a crystalline solid. It can range in color from off-white to pale yellow. Under specific purification conditions, it might even appear as white crystals.

Comment on solubility

Solubility of 6-amino-5-iodo-1H-pyrimidin-2-one

The solubility of 6-amino-5-iodo-1H-pyrimidin-2-one can be influenced by several factors, making it an interesting topic for discussion. This compound is known to exhibit a variety of solubility characteristics due to its chemical structure.

Factors Affecting Solubility

When examining the solubility of this compound, consider the following:

  • Polarity: The presence of amino and iodide groups in its structure increases polarity, which can enhance solubility in polar solvents like water.
  • Hydrogen Bonding: The amino group allows for potential hydrogen bonding, increasing interactions with solvent molecules and improving solubility.
  • pH Levels: The solubility of many pyrimidine derivatives can also be influenced by the pH of the solution; acidic or basic conditions may alter the ionization of the amino group.

General Observations

Based on available data, the solubility of 6-amino-5-iodo-1H-pyrimidin-2-one in water is described as:

  • Moderate: Generally soluble in water but with varying degrees depending on specific conditions.
  • Solvent-Specific: Better solubility might be observed in organic solvents, possibly leading to enhanced applications in pharmaceuticals.

In summary, while 6-amino-5-iodo-1H-pyrimidin-2-one has some degree of solubility in polar solvents, environmental factors such as pH and solvent choice play critical roles in determining its overall solubility profile.

Interesting facts

Interesting Facts about 6-amino-5-iodo-1H-pyrimidin-2-one

6-amino-5-iodo-1H-pyrimidin-2-one is a fascinating compound with a variety of applications in both medicine and biochemistry. Here are some compelling insights:

  • Structural Significance: This compound features a pyrimidine ring, which is known for its role as a *building block* in many important biological molecules, including nucleic acids like DNA and RNA.
  • Pharmacological Interest: The presence of the amino group (-NH2) and iodine substituent suggests enhanced reactivity, making it valuable in drug design, specifically in developing antiviral agents and treatments for cancer.
  • Research Applications: Scientists often utilize derivatives of this compound in *medicinal chemistry* to explore their efficacy against various diseases. Its structure can be modified to optimize biological activities and reduce toxicity.
  • Biological Activity: Compounds similar to 6-amino-5-iodo-1H-pyrimidin-2-one exhibit a wide range of *biological activities*, including antimicrobial and anticancer properties.
  • Novel Synthetic Pathways: The synthesis of this compound can lead to innovative synthetic strategies involving the introduction of other functional groups, which can further expand its applications in organic synthesis.
  • Key Intermediates: In synthetic chemistry, this compound can act as an *intermediate* in the synthesis of other complex organic molecules, potentially leading to the development of new therapeutic agents.

Due to its unique structure and biological relevance, 6-amino-5-iodo-1H-pyrimidin-2-one remains an *important subject of study* in various fields of research, opening doors for potential breakthroughs in pharmaceuticals and beyond.

Synonyms
5-Iodocytosine
1122-44-7
CYTOSINE, 5-IODO-
4-Amino-5-iodo-2(1H)-pyrimidinone
4-amino-5-iodo-1,2-dihydropyrimidin-2-one
DTXSID40149947
DTXCID5072438
625-390-5
4-amino-5-iodopyrimidin-2(1H)-one
6-Amino-5-iodopyrimidin-2(1H)-one
6-amino-5-iodo-1H-pyrimidin-2-one
2(1H)-Pyrimidinone, 4-amino-5-iodo-
4-amino-5-iodo-1H-pyrimidin-2-one
4-Amino-2-hydroxy-5-iodopyrimidine
MFCD00023162
2(1H)-Pyrimidinone,6-amino-5-iodo-
5-odocytosine
4-Amino-5-iodo-2-pyrimidinol
4-amino-5-iodopyrimidinone
SCHEMBL8815
ALBB-023644
CS-M0719
TD8031
AKOS015919517
AKOS015998182
AKOS025117166
FI08021
SB55521
AC-25656
AS-19496
SY021694
DB-041061
EN300-719480
AG-690/12885355
4-Amino-2-hydroxy-5-iodopyrimidine;6-Amino-5-iodopyrimidin-2(1H)-one