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Cytarabine

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Identification
Molecular formula
C9H13N3O5
CAS number
147-94-4
IUPAC name
6-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1-methyl-purin-2-one
State
State
Cytarabine is typically solid at room temperature, forming a crystalline powder. It is usually devoid of any odor.
Melting point (Celsius)
212.00
Melting point (Kelvin)
485.15
Boiling point (Celsius)
444.00
Boiling point (Kelvin)
717.15
General information
Molecular weight
243.22g/mol
Molar mass
243.2200g/mol
Density
1.6500g/cm3
Appearence

Cytarabine is generally found as a white to off-white crystalline powder. It is known for its limited solubility in water, which is important in its preparation for medical use.

Comment on solubility

Solubility of 6-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1-methyl-purin-2-one

The solubility of the compound 6-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1-methyl-purin-2-one (C9H13N3O5) is influenced by various factors related to its molecular structure and functional groups. Understanding the solubility characteristics of this compound can be key for its applications in pharmaceuticals and biological systems.

Key Points about Solubility:

  • Polarity: Due to the presence of multiple hydroxyl groups (–OH) and amino groups (–NH2), this compound is expected to exhibit high polarity, thus enhancing its solubility in polar solvents such as water.
  • Hydrogen Bonding: The functional groups allow for strong hydrogen bonding with solvents, which typically increases solubility.
  • Solvent Influence: The solubility may vary significantly with the type of solvent. It is likely to be more soluble in aqueous solutions than in nonpolar organic solvents.
  • Temperature Dependency: Like many compounds, solubility can increase with temperature; thus, heating the solution may enhance the dissolving process.

In description, it can be concluded that the intricate balance of polar and non-polar characteristics, as well as the influence of functional groups on hydrogen bonding, plays a crucial role in determining the solubility of this compound. However, experimental data is essential for providing precise solubility values and behavior under different conditions.

Interesting facts

Interesting Facts about 6-Amino-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1-methyl-purin-2-one

This compound, known for its complex structure and unique properties, plays a significant role in the field of biochemistry and pharmaceutical sciences. Below are some interesting facts that highlight its importance:

  • Biochemical Significance: As a purine derivative, this compound is related to nucleic acids, which are essential for storing and transmitting genetic information in living organisms.
  • Potential Therapeutic Applications: Research suggests that compounds similar to this one could have diverse biological activities, including anti-viral and anti-cancer properties. Exploring its derivatives may lead to the development of new medications.
  • Catalytic Properties: This compound may exhibit unique catalytic properties in certain biochemical reactions. Its structure allows it to act as a potential enzyme or active site mimic.
  • Structural Complexity: The presence of a tetrahydrofuran ring and multiple hydroxyl groups contribute to its diverse chemical reactivity. Understanding these interactions can shed light on enzyme scaffolding in biological systems.
  • Synthesis Challenges: The synthesis of such a compound requires advanced chemical techniques and a thorough understanding of organic synthesis methods, making it an intriguing subject of study for chemists.
  • Research Potential: Ongoing studies may elucidate its role in medicinal chemistry, leading to breakthroughs in drug development targeting specific diseases.

In conclusion, 6-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1-methyl-purin-2-one serves as a prime example of how complex organic compounds can have significant biological implications and potential therapeutic benefits. Its study not only enriches our understanding of biochemistry but also paves the way for innovative approaches in drug discovery.

Synonyms
SCHEMBL14614880
6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methyl-2,9-dihydro-1H-purin-2-one
6-amino-9-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-methyl-1H-purin-2(9H)-one