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6-Aminonicotinic acid

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Identification
Molecular formula
C6H6N2O2
CAS number
636-93-1
IUPAC name
6-aminopyridine-3-carboxylic acid
State
State

At room temperature, 6-Aminonicotinic acid is in a solid state, typically found in a crystalline form. The solid nature allows it to be stored and handled under standard laboratory conditions, making it well-suited for chemical synthesis and research applications.

Melting point (Celsius)
253.00
Melting point (Kelvin)
526.15
Boiling point (Celsius)
342.00
Boiling point (Kelvin)
615.15
General information
Molecular weight
138.12g/mol
Molar mass
138.1210g/mol
Density
1.5235g/cm3
Appearence

6-Aminonicotinic acid appears as white to light yellow crystalline powder. It is generally odorless and has a slightly bitter taste. The texture is consistent with that of fine crystalline solids, offering a powder-like consistency that is easily manipulable with appropriate laboratory tools.

Comment on solubility

Solubility of 6-Aminopyridine-3-Carboxylic Acid

6-Aminopyridine-3-carboxylic acid, often referred to as 3-APA, exhibits varying solubility characteristics that are important for its applications in different fields, particularly in pharmaceuticals and organic chemistry.

This compound is generally considered to be:

  • Soluble in Water: It shows reasonable solubility in polar solvents like water due to the presence of both amino and carboxylic acid functional groups, which can engage in hydrogen bonding.
  • Slightly Soluble in Organic Solvents: When it comes to non-polar solvents, the solubility tends to be very low or negligible. Thus, it is important for researchers to choose appropriate solvents based on the solubility profile.
  • pH-Dependent: The solubility of 6-aminopyridine-3-carboxylic acid can also vary with pH, being more soluble in acidic or basic conditions due to different ionization states of the functional groups.

This information is crucial when considering 6-aminopyridine-3-carboxylic acid for synthesis or research purposes, as the solubility will impact the reactivity and stability of the compound in solution. Remember, “solubility is key to reactivity,” and understanding the solubility behavior can lead to more effective experimental designs.

Interesting facts

Interesting Facts about 6-Aminopyridine-3-Carboxylic Acid

6-Aminopyridine-3-carboxylic acid, also known as 3-carboxy-6-aminopyridine, is a fascinating compound within the realm of organic chemistry. This compound features a pyridine ring, which is a six-membered aromatic ring containing one nitrogen atom. Here are some compelling aspects of this intriguing chemical:

  • Biological Significance: This compound plays a role in various biological systems and has been studied for its potential pharmacological activities.
  • Precursor in Synthesis: It serves as a precursor in the synthesis of several other complex compounds, making it a valuable building block in chemical research.
  • Role in Medicine: Research has indicated that 6-aminopyridine derivatives have therapeutic potential in neurology, particularly in the treatment of conditions like multiple sclerosis.
  • Intriguing Reactivity: Its unique reactivity pattern allows it to participate in a variety of chemical reactions, including acylation and alkylation, further demonstrating its versatility.
  • Research Implications: Studies have shown that derivatives of this compound can influence biological interactions, which makes it a point of interest for drug development.

In the world of synthetic chemistry, understanding the properties and applications of compounds like 6-Aminopyridine-3-Carboxylic Acid can lead to significant advancements in pharmaceutical science and molecular biology. As researchers continue to explore its potential, this compound stands out as a prime candidate for innovative solutions in treating complex diseases.

As one researcher noted, "The ability of 6-aminopyridine-3-carboxylic acid to serve as a versatile precursor opens doors to new avenues in drug synthesis."

Synonyms
6-Aminonicotinic acid
6-Aminopyridine-3-carboxylic acid
3-Pyridinecarboxylic acid, 6-amino-
2-Amino-5-pyridinecarboxylic acid
Nicotinic acid, 6-amino-
CHEBI:68583
UNII-9VR2O1OK60
9VR2O1OK60
EINECS 221-630-4
NSC 229361
NSC-229361
DTXSID6062882
2-AMINO-5-CARBOXYPYRIDINE
6-AMINONICOTINIC ACID [MI]
DTXCID6038401
Nicotinic acid, 6-amino-(8CI)
221-630-4
zcifwrhiebxboy-uhfffaoysa-n
3167-49-5
6-amino-nicotinic acid
6-Amino Nicotinic Acid
MFCD00006326
2-aminopyridine-5-carboxylic acid
6-AMINO-3-PYRIDINECARBOXYLIC ACID
CHEMBL3322864
6-Aminonicotinicacid
6-Aminopyridine 3-carboxylic acid
6aminonicotinic acid
6-Amino-nicotinsaure
SCHEMBL42011
HMS1788O22
2-amino-5-pyridine carboxylic acid
6-amino pyridine 3-carboxylic acid
6-amino-pyridine-3-carboxylic acid
ALBB-005967
BCP27406
BBL018585
BDBM50052793
CL1029
GEO-00184
NSC229361
STK500454
AKOS000118863
AC-3154
CS-W016509
FA07683
HY-W015793
PB21621
PS-5331
NCGC00339129-01
6-Aminopyridine-3-carboxylic acid, 97%
BP-10196
PD158964
SY004091
DB-009084
A1486
NS00014696
EN300-18748
AB00443426-03
AI-942/25034199
Q27137025
Z90122558
F0001-0950
InChI=1/C6H6N2O2/c7-5-2-1-4(3-8-5)6(9)10/h1-3H,(H2,7,8)(H,9,10