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6-Bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C8H3BrF3N3O2
CAS number
93276-53-4
IUPAC name
6-bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, 6-Bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole is typically a solid. It is stable under standard conditions and should be handled with appropriate safety measures due to its potential irritant nature.

Melting point (Celsius)
151.00
Melting point (Kelvin)
424.15
Boiling point (Celsius)
330.00
Boiling point (Kelvin)
603.15
General information
Molecular weight
335.03g/mol
Molar mass
335.0100g/mol
Density
2.0190g/cm3
Appearence

6-Bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole appears as a yellow to orange solid. Its coloration is characteristic due to the presence of the nitro group, which often imparts a yellow hue to aromatic compounds. The compound is typically available in powder form.

Comment on solubility

Solubility of 6-Bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 6-bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole is an intriguing aspect due to its unique chemical structure. The presence of multiple functional groups can influence its solubility profile in various solvents. Consider the following points:

  • Polar vs. Non-Polar Solvents: This compound may exhibit higher solubility in polar solvents like dimethyl sulfoxide (DMSO) or methanol compared to non-polar solvents, due to the electron-withdrawing effect of the nitro and trifluoromethyl groups.
  • Hydrophobic Nature: The fluorinated moiety contributes to the hydrophobic character, potentially making the compound less soluble in aqueous solutions.
  • pH Dependence: The solubility might vary significantly with changes in pH, as protonation states of the nitrogen atoms in the benzimidazole ring can alter solubility characteristics.

It is often noted that “the solubility of a substance is a key parameter that dictates its bioavailability and reactivity in solutions.” Thus, understanding the solubility behavior of 6-bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole is essential for its applications in various chemical processes. Conducting systematic solubility tests across a range of solvents can provide insight into its practical uses and limitations.

Interesting facts

Interesting Facts about 6-Bromo-4-Nitro-2-(Trifluoromethyl)-1H-Benzimidazole

6-Bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound that draws significant interest from chemists due to its versatile applications and unique properties. Here are some noteworthy facts about this compound:

  • Diverse Applications: This compound is often utilized in pharmaceutical research, particularly in drug development. Its structure allows for potential bioactivity, which can lead to the discovery of new therapeutic agents.
  • Substituted Aromatics: The presence of both bromine and nitro groups introduces a variety of electron-withdrawing effects that can significantly influence the compound's reactivity. This makes it a valuable target for further synthetic modification.
  • Trifluoromethyl Moiety: The trifluoromethyl group is known for enhancing the lipophilicity of compounds, which plays a critical role in improving biological activity and bioavailability in medicinal chemistry.
  • Importance in Material Science: In addition to its pharmaceutical applications, compounds like 6-bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole are important in material science for their potential in developing advanced materials or catalysts.

The synthesis and study of this compound not only contribute to the field of chemistry but also pave the way for innovations in various scientific disciplines. As one researcher aptly stated, “The magic of chemistry lies in its ability to transform simple elements into complex compounds with profound impacts.” Through ongoing research and exploration, compounds like this continue to demonstrate the intricate dance of molecular interactions and their significance in our daily lives.

Overall, 6-bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole stands as a potent reminder of the potential hidden within complex chemical structures. Further studies can unlock even more of its secrets, leading to exciting discoveries in health and technology.

Synonyms
BENZIMIDAZOLE, 6-BROMO-4-NITRO-2-(TRIFLUOROMETHYL)-
BRN 0926084
6609-36-5
6-Bromo-4-nitro-2-(trifluoromethyl)benzimidazole
DTXSID00216280
DTXCID00138771
USUPLSWSXSTERT-UHFFFAOYSA-N