Berberine | Solubility of Things

Identification

Molecular formula

C₂₀H₁₈NO₄

CAS number

2086-83-1

IUPAC name

6-butyl-4-methoxy-[1,3]dioxolo[4,5-g]isoquinolin-6-ium

State

At room temperature, berberine is typically a solid. It is often found in powdered form and is notable for its bright yellow color.

Melting point (Celsius)

145.00

Melting point (Kelvin)

418.15

Boiling point (Celsius)

464.15

Boiling point (Kelvin)

737.30

General information

Molecular weight

336.36g/mol

Molar mass

336.3610g/mol

Density

1.3603g/cm³

Appearence

Berberine is a bright yellow crystalline powder. It has a distinct ochre color and is often used as a natural dye due to its intense yellow appearance.

Comment on solubility

Solubility of 6-butyl-4-methoxy-[1,3]dioxolo[4,5-g]isoquinolin-6-ium

The solubility of 6-butyl-4-methoxy-[1,3]dioxolo[4,5-g]isoquinolin-6-ium is influenced by several factors. Generally, the interaction between the compound and the solvent plays a critical role in determining how well it dissolves. Here are some key considerations:

Polarity: The presence of polar functional groups in the structure may enhance solubility in polar solvents such as water.
Hydrophobic regions: The butyl group increases hydrophobic character, which can lead to better solubility in organic solvents like ethanol or acetone.
Hydrogen bonding: Compounds capable of hydrogen bonding may exhibit increased solubility in solvents that can act as hydrogen bond donors or acceptors.
Temperature: Elevated temperatures can generally improve solubility for many compounds, potentially leading to increased dissolution rates and quantities.

In general, the solubility of this compound can be summarized as variable, depending on the solvent environment. Therefore, it is essential to test the compound’s solubility in various solvents to ascertain its practical applications. As a rule of thumb, “like dissolves like”, showcasing that similar polarities generally lead to more effective solubility.

Interesting facts

Interesting Facts about 6-butyl-4-methoxy-[1,3]dioxolo[4,5-g]isoquinolin-6-ium

This fascinating compound belongs to a class of molecules known as isoquinolines, which are important in medicinal chemistry due to their various biological activities. Isoquinolines are primarily known for their alkaloidal properties, providing a rich source of potential therapeutic agents. The specific structure of 6-butyl-4-methoxy-[1,3]dioxolo[4,5-g]isoquinolin-6-ium intrigues researchers for several reasons:

Diverse Applications: Compounds like this isoquinoline derivative have shown promise in drug development, particularly in treating neurological disorders and cancers.
Enhanced Solubility: The butyl group in its structure contributes to improved lipophilicity, which is critical for the absorption and bioavailability of medicinal compounds.
Unique Stability: The presence of the dioxolo ring provides stability to the molecule, which is advantageous in various chemical reactions.
Structural Complexity: The intricate arrangement of atoms in this compound highlights the beauty of organic synthesis and challenges faced in creating such complex molecules.

As scientists study 6-butyl-4-methoxy-[1,3]dioxolo[4,5-g]isoquinolin-6-ium, they often remark, "The complexity of chemical structures like this compels us to explore the potential they hold in revolutionizing pharmacology." It encapsulates the excitement of discovering new treatments through the meticulous design of organic compounds.

In conclusion, the exploration of isoquinoline derivatives such as this compound not only extends our understanding of organic chemistry but also opens doors to innovative approaches in the treatment of various diseases. Its unique characteristics make it a subject of interest for both chemists and pharmacologists alike.