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Chlorothiazide

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Identification
Molecular formula
C7H6ClN3O4S2
CAS number
58-94-6
IUPAC name
6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
State
State

Chlorothiazide is in a solid state at room temperature.

Melting point (Celsius)
355.00
Melting point (Kelvin)
628.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
295.72g/mol
Molar mass
295.7200g/mol
Density
1.5700g/cm3
Appearence

Chlorothiazide is typically found as a white or practically white, crystalline powder. It can also be seen in other solid forms depending on the specific pharmaceutical formulation. It is odorless and has a bitter taste.

Comment on solubility

Solubility of 6-chloro-1,1-dioxo-4H-1<lambda>6,2,4-benzothiadiazine-7-sulfonamide

The compound 6-chloro-1,1-dioxo-4H-1<lambda>6,2,4-benzothiadiazine-7-sulfonamide, with the chemical formula C7H6ClN3O4S2, presents notable characteristics regarding its solubility. Here are some key points to consider:

  • Polarity: The presence of sulfonamide and dioxo functional groups contributes to its polar nature, improving solubility in polar solvents.
  • Water Solubility: The compound is expected to have moderate water solubility due to its ionic character; however, it may not be highly soluble given the presence of a chlorine atom, which can deter dissolution in water.
  • Solvent Compatibility: This compound is likely to be more soluble in protic solvents such as ethanol and methanol compared to non-polar solvents.
  • Temperature Effect: Like many other compounds, solubility may increase with temperature, making it essential to explore conditions for optimal dissolution.

In summary, understanding the solubility profile of 6-chloro-1,1-dioxo-4H-1<lambda>6,2,4-benzothiadiazine-7-sulfonamide aids in predicting its behavior in various chemical environments and influences its potential applications.

Interesting facts

Exploring 6-Chloro-1,1-dioxo-4H-1λ6,2,4-benzothiadiazine-7-sulfonamide

6-Chloro-1,1-dioxo-4H-1λ6,2,4-benzothiadiazine-7-sulfonamide is a fascinating compound with noteworthy characteristics that make it significant in various fields of research. This compound, belonging to the class of benzothiadiazines, is recognized for its unique structure which includes:

  • Chlorine Substitution: The presence of a chlorine atom in its structure plays an important role in its reactivity and biological activity.
  • Dioxo Functional Groups: The dioxo functionality contributes to the compound's potential as an electrophile, making it interesting for synthetic applications.
  • Thiadiazine Ring System: This ring is central to the compound's properties and provides a basis for exploring its function in medicinal chemistry.

This compound is known for its utility in various research applications, particularly in the pharmaceutical industry. Here are some compelling reasons for its scientific interest:

  1. Potential Pharmacological Activity: Compounds like 6-chloro-1,1-dioxo-4H-1λ6,2,4-benzothiadiazine-7-sulfonamide are often screened for their antimicrobial and anti-inflammatory properties.
  2. Versatile Derivative: Its structure makes it a valuable precursor in the synthesis of other chemical entities, thereby expanding its relevance in the synthesis of complex molecules.
  3. Environmental Relevance: The study of such compounds may also have implications in understanding environmental pollutants and their biological interactions.

In summary, the study of 6-chloro-1,1-dioxo-4H-1λ6,2,4-benzothiadiazine-7-sulfonamide opens up numerous avenues for exploration in both theoretical and applied chemistry. Its unique structural features and potential applications make it a key focus for researchers aiming to expand our understanding of benzothiadiazine chemistry.

Synonyms
chlorothiazide
58-94-6
Diuril
Chlorthiazide
Chlorothiazid
Chlotride
Flumen
Chlorosal
Chlortiazid
Chlorurit
Clotride
Diuresal
Diurilix
Saluretil
Thiazide
Warduzide
Alurene
Diurite
Diutrid
Minzil
Salisan
Salunil
Saluric
Urinex
Yadalan
Neo-Dema
Chlorothiazidum
Clorotiazida
Sk-chlorothiazide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
Chloriazid
Chlrosal
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
component of Aldoclor
MFCD00058576
NSC 25693
NSC-25693
CHEBI:3640
DTXSID0022800
NSC25693
Diuril (TN)
77W477J15H
MLS000028398
DTXCID802800
Chlorthiazid
Chlorthiazidum
6-chloro-1,1-dioxo-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
CAS-58-94-6
NCGC00015242-04
Clorotiazide
SMR000058429
6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Clorotiazide [DCIT]
Diuril Boluses
6-chloro-1,1-dioxo-4H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
Diuril Boluses, Veterinary
CHLOROTHIAZIDE (MART.)
CHLOROTHIAZIDE [MART.]
Clorotiazida [INN-Spanish]
Chlorothiazidum [INN-Latin]
CHLOROTHIAZIDE (EP IMPURITY)
CHLOROTHIAZIDE [EP IMPURITY]
CHLOROTHIAZIDE (USP IMPURITY)
CHLOROTHIAZIDE [USP IMPURITY]
CHLOROTHIAZIDE (USP MONOGRAPH)
CHLOROTHIAZIDE [USP MONOGRAPH]
CCRIS 5999
HSDB 3030
SR-01000075604
HYDROCHLOROTHIAZIDE IMPURITY A (EP IMPURITY)
HYDROCHLOROTHIAZIDE IMPURITY A [EP IMPURITY]
EINECS 200-404-9
6-chloro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide
Chlorothiazide (JAN/USP/INN)
Chlorothiazide [USP:INN:BAN]
UNII-77W477J15H
6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo(1,2,4)thiadiazine-7-sulfonic acid amide
6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide
Prestwick_56
EXURIL
YADULAN
Diupres (Salt/Mix)
Aldoclor (Salt/Mix)
RO-CHLOROZIDE
Spectrum_000134
Prestwick0_000251
Prestwick1_000251
Prestwick2_000251
Prestwick3_000251
Spectrum2_000154
Spectrum3_000342
Spectrum4_000280
Spectrum5_001446
Chlorothiazide (Standard)
Lopac-C-4911
CHEMBL842
C 4911
CHLOROTHIAZIDE [MI]
cid_2720
CHLOROTHIAZIDE [INN]
CHLOROTHIAZIDE [JAN]
Lopac0_000254
SCHEMBL22329
BSPBio_000062
BSPBio_002003
CHLOROTHIAZIDE [HSDB]
KBioGR_000780
KBioSS_000594
BIDD:GT0635
CHLOROTHIAZIDE [VANDF]
DivK1c_000675
SPECTRUM1500180
SPBio_000288
SPBio_002281
BPBio1_000070
GTPL4835
CHLOROTHIAZIDE [WHO-DD]
CHEMBL3392493
BDBM39351
Chlorothiazide, thiazide diuretic
HMS502B17
HY-B0224R
KBio1_000675
KBio2_000594
KBio2_003162
KBio2_005730
KBio3_001223
C03AA04
NINDS_000675
HMS1568D04
HMS1920K15
HMS2091C18
HMS2095D04
HMS2232N22
HMS3259K15
HMS3260D10
HMS3370A15
HMS3655M13
HMS3712D04
Pharmakon1600-01500180
CHLOROTHIAZIDE [GREEN BOOK]
BCP24474
HY-B0224
MSK10325
CHLOROTHIAZIDE [ORANGE BOOK]
Tox21_110107
Tox21_200972
Tox21_500254
WLN: T66 BSWM ENJ HG ISZW
6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
CCG-38953
NSC756682
s1641
AKOS015896601
AKOS024319450
Tox21_110107_1
DB00880
FC20399
LP00254
NC00500
NSC-756682
SDCCGSBI-0050242.P005
IDI1_000675
NCGC00015242-01
NCGC00015242-02
NCGC00015242-03
NCGC00015242-05
NCGC00015242-06
NCGC00015242-07
NCGC00015242-08
NCGC00015242-09
NCGC00015242-10
NCGC00015242-12
NCGC00015242-13
NCGC00015242-19
NCGC00091042-01
NCGC00091042-02
NCGC00091042-03
NCGC00091042-04
NCGC00091042-05
NCGC00258525-01
NCGC00260939-01
1ST10325
AC-18732
AS-11760
DA-51859
SBI-0050242.P004
C2259
EU-0100254
Hydrochlorothiazide impurity, chlorothiazide-
NS00000586
SW219268-1
Chlorothiazide 100 microg/mL in Acetonitrile
C07461
D00519
D89501
AB00051940-04
AB00051940_05
AB00051940_06
Q2603363
SR-01000075604-1
SR-01000075604-3
SR-01000075604-5
BRD-K88682005-001-05-9
BRD-K88682005-001-07-5
BRD-K88682005-001-15-8
BRD-K88682005-001-16-6
Z1501480416
6-Chloro-7-sulfamoyl-2H-1,4-benzothiadiazine 1,1-dioxide
6-Chloro-2H-1,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-chloro-4H-1,2,4-benzathiadiazine-7-sulfonamide-1,1-dioxide
Chlorothiazide, European Pharmacopoeia (EP) Reference Standard
2H-1,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
6-chloro-1,1-dioxo-4H-1$l^{6,2,4-benzothiadiazine-7-sulfonamide
6-chloro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
6-CHLORO-7-SULFAMYL-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE
Chlorothiazide, United States Pharmacopeia (USP) Reference Standard
HYDROCHLOROTHIAZIDE IMPURITY, CHLOROTHIAZIDE- [USP IMPURITY]
HYDROCHLOROTHIAZIDE IMPURITY, CHLOROTHIAZIDE-(USP IMPURITY)
2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE, 6-CHLORO-,1,1-DIOXIDE
Chlorothiazide, Pharmaceutical Secondary Standard; Certified Reference Material
200-404-9
6-Chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide;6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;Chlorthiazide