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6-Chloro-1H-benzimidazol-2-amine

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Identification
Molecular formula
C7H6ClN3
CAS number
4380-14-3
IUPAC name
6-chloro-1H-benzimidazol-2-amine
State
State

At room temperature, 6-Chloro-1H-benzimidazol-2-amine is in a solid state. It is typically handled as a powder as it doesn't vaporize easily under standard atmospheric conditions.

Melting point (Celsius)
293.50
Melting point (Kelvin)
566.65
Boiling point (Celsius)
540.00
Boiling point (Kelvin)
813.15
General information
Molecular weight
167.59g/mol
Molar mass
167.5820g/mol
Density
1.5900g/cm3
Appearence

6-Chloro-1H-benzimidazol-2-amine typically appears as a crystalline solid. It may range from white to off-white or pale yellow in color. The compound is generally in the form of fine, powdery crystals under standard conditions.

Comment on solubility

Solubility of 6-chloro-1H-benzimidazol-2-amine

The solubility of 6-chloro-1H-benzimidazol-2-amine can vary based on several factors, including the solvent used and the temperature. Here are some key points to consider:

  • Solvent Interaction: This compound may demonstrate varying solubility in different solvents, particularly polar vs. non-polar solvents. Polar solvents like water or methanol might promote better solubility due to the potential for hydrogen bonding.
  • Temperature Dependence: The solubility typically increases with temperature. Therefore, higher temperatures may facilitate the dissolution of 6-chloro-1H-benzimidazol-2-amine in a solvent.
  • pH Influence: The pH of the solution can play a significant role. As an amine, the compound might become protonated in acidic conditions, enhancing its solubility in aqueous environments.

To summarize, understanding the solubility of 6-chloro-1H-benzimidazol-2-amine requires consideration of the:

  1. Type of solvent
  2. Temperature of the system
  3. Acidity or basicity of the solution

Ultimately, the specific solubility characteristics are crucial for its applications in various chemical reactions and formulations.

Interesting facts

Interesting Facts about 6-Chloro-1H-benzimidazol-2-amine

6-Chloro-1H-benzimidazol-2-amine is a fascinating compound with several intriguing aspects relevant to both its structure and its applications in various fields of science. Here are some noteworthy points:

  • Unique Structure: This compound features a benzimidazole core, which is a bicyclic structure comprised of a benzene ring fused to an imidazole. This unique feature grants it specific chemical properties.
  • Biological Activity: Compounds that resemble benzimidazole often exhibit significant biological activities, making them candidates for pharmaceutical research. Its derivatives have shown promise in treating a range of conditions, from antiparasitic to anti-cancer effects.
  • Chlorine Substitution: The presence of a chlorine atom at the 6th position suggests a potential for increased activity or specificity in biological systems, possibly influencing how the compound interacts with enzymes or receptors.
  • Synthetic Versatility: The simplicity of its synthesis makes 6-Chloro-1H-benzimidazol-2-amine an attractive target for medicinal chemists looking to develop new derivatives for drug discovery.
  • Research Potential: Given its structural features, ongoing research is likely to explore its role in various biochemical pathways, paving the way for new insights and innovations in medicinal chemistry.

As scientific inquiry continues to unveil the properties of 6-Chloro-1H-benzimidazol-2-amine, it stands out as a testament to the beauty and complexity of organic compounds. Its blend of structural integrity and potential applications highlights the importance of such compounds in the development of modern therapeutics.

Synonyms
5-Chloro-2-aminobenzimidazole
Benzimidazole, 2-amino-6-chloro-
CCRIS 4359
BENZIMIDAZOLE, 2-AMINO-5-CHLORO-
NSC 10545
1H-Benzimidazol-2-amine, 6-chloro-
6-chloro-1H-1,3-benzodiazol-2-amine
673-313-9
5418-93-9
2-amino-6-chlorobenzimidazole
6-chloro-1H-benzimidazol-2-amine
6-chloro-1H-benzo[d]imidazol-2-amine
1H-Benzimidazol-2-amine, 5-chloro-
Atomoxetine EP Impurity A
2-Amino-5-chlorobenzimidazole
5-Chloro-1H-benzoimidazol-2-ylamine
5-chloro-1H-benzimidazol-2-amine
56161-70-7
MLS002638147
CHEMBL269158
5-CHLORO-1H-1,3-BENZODIAZOL-2-AMINE
2-Amino-5-chloro-1H-benzimidazole
NSC10545
VGD
MFCD08234599
3kr1
2amino5chlorobenzimidazole
2amino6chlorobenzimidazole
Oprea1_317702
Oprea1_834530
SCHEMBL216615
2-amino-5-chloro-benzimidazole
2-aminobenzimidazole deriv., 4
DTXSID1063857
BDBM31794
HMS3080J07
FAA41893
AC8852
MFCD00749332
NSC-10545
AKOS000540719
AKOS015914093
AKOS025244158
5-chloro-1H-benzo[d]imidazol-2-amine
AB07015
FS-1408
SDCCGSBI-0658226.P001
(5-chloro-1H-benzoimidazol-2-yl)-amine
PD129920
SMR000734645
SY041922
DB-020490
EN300-155180
G83814
5-Chloro-1H-benzimidazol-2-ylamine, AldrichCPR
SR-01000396932
SR-01000396932-1
Q27467045