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6-Chloro-2-cyclohexyl-3-oxoisoindoline-5-sulfonamide

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Identification
Molecular formula
C14H15ClN2O3S
CAS number
30191-57-2
IUPAC name
6-chloro-2-cyclohexyl-3-oxo-isoindoline-5-sulfonamide
State
State

At room temperature, 6-chloro-2-cyclohexyl-3-oxoisoindoline-5-sulfonamide is typically encountered as a solid.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
560.00
Boiling point (Kelvin)
833.15
General information
Molecular weight
370.88g/mol
Molar mass
370.8810g/mol
Density
1.3850g/cm3
Appearence

Typically in the form of a crystalline powder. Color may range from white to off-white depending on purity and processing. It may also appear slightly yellowish if impurities are present.

Comment on solubility

Solubility of 6-chloro-2-cyclohexyl-3-oxo-isoindoline-5-sulfonamide

The solubility of 6-chloro-2-cyclohexyl-3-oxo-isoindoline-5-sulfonamide (C14H15ClN2O3S) can be described as follows:

  • General Characteristics: This compound possesses both hydrophilic and hydrophobic features due to its complex structure, making its solubility behavior somewhat intriguing.
  • Solubility in Water: It is generally considered to have limited solubility in water, particularly due to the presence of the cyclohexyl and the sulfonamide groups which can hinder effective interactions with water molecules.
  • Solvents: Although water solubility is low, it may dissolve better in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol. This indicates a tendency towards apolar interactions.
  • Influencing Factors: Factors such as pH, temperature, and the presence of other solutes can significantly influence the solubility of this compound.

Overall, while 6-chloro-2-cyclohexyl-3-oxo-isoindoline-5-sulfonamide displays a degree of restricted solubility, understanding its interactions with different solvents can be crucial for its application in various chemical and pharmaceutical contexts.

Interesting facts

Interesting Facts about 6-Chloro-2-cyclohexyl-3-oxo-isoindoline-5-sulfonamide

The compound 6-chloro-2-cyclohexyl-3-oxo-isoindoline-5-sulfonamide is an intriguing member of the sulfonamide family, known for its diverse applications in medicinal chemistry. Here are some interesting aspects of this compound:

  • Structural Features: This molecule contains a unique isoindoline framework, which is characterized by a fused bicyclic system. The incorporation of a sulfonamide group enhances its biological activity, allowing it to act as a potential drug candidate.
  • Biological Activity: Sulfonamides are known for their antibacterial properties. The modifications within this compound may influence its efficacy against various bacterial strains, making it a subject of research in the field of pharmacology.
  • Drug Design: The presence of both a chloro group and a cyclohexyl group suggests it has interesting lipophilic properties, which can affect its bioavailability and interaction with biological targets.
  • Research Applications: Ongoing studies on isoindoline derivatives look at their potential applications not only as antibiotics but also in other therapeutic areas such as cancer treatment and anti-inflammatory agents.
  • Quote from Research: As one researcher stated, "The sulfonamide class continues to be a fertile area for exploring novel compounds with improved efficacy and reduced side effects."

In conclusion, 6-chloro-2-cyclohexyl-3-oxo-isoindoline-5-sulfonamide exemplifies the dynamic intersection of chemistry and pharmacology, serving as a potential lead compound for future drug development.

Synonyms
Clorexolone
Chlorexolone
2127-01-7
Clorexolon
Flonatril
Nefrolan
Klorex
Clorexolona
Cloresolone [DCIT]
Cloresolone
Clorexolonum
Clorexolonum [INN-Latin]
Clorexolona [INN-Spanish]
Q2PLT3FS05
Clorexolone [USAN:INN:BAN]
DTXSID4057683
6-Chloro-2-cyclohexyl-3-oxo-5-isoindolinesulfonamide
M & B 8430
CLOREXOLONE [MI]
EINECS 218-342-6
CLOREXOLONE [INN]
CLOREXOLONE [JAN]
CLOREXOLONE [USAN]
1H-Isoindole-5-sulfonamide, 6-chloro-2-cyclohexyl-2,3-dihydro-3-oxo-
BRN 0493411
CLOREXOLONE [MART.]
5-Chloro-2-cyclohexyl-1-oxo-6-sulphamoylisoindoline
CLOREXOLONE [WHO-DD]
12833 R.P.
DTXCID5031472
5-ISOINDOLINESULFONAMIDE, 6-CHLORO-2-CYCLOHEXYL-3-OXO-
6-Chloro-2-cyclohexyl-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonamide
1H-Isoindole-5-sulfonamide, 2,3-dihydro-6-chloro-2-cyclohexyl-3-oxo-
RP 12833
Clorexolonum (INN-Latin)
Clorexolona (INN-Spanish)
CLOREXOLONE (MART.)
5-22-07-00591 (Beilstein Handbook Reference)
C03BA12
6-chloro-2-cyclohexyl-3-oxo-2,3-dihydro-1H-isoindole-5-sulfonamide
218-342-6
6-chloro-2-cyclohexyl-3-oxoisoindoline-5-sulfonamide
6-chloro-2-cyclohexyl-3-oxo-1H-isoindole-5-sulfonamide
Flonatril; Klorex; Nefrolan; RP 12833
UNII-Q2PLT3FS05
SCHEMBL310673
Clorexolone (JAN/USAN/INN)
CHEMBL2106167
CHEBI:31421
Tox21_113742
AKOS040751225
DB13617
NCGC00253608-01
RP-12833
CAS-2127-01-7
NS00045665
D01436
SBI-0654646.0001
Q5135140