Interesting facts
Interesting Facts about 6-Chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide
This intriguing compound is a part of the benzothiadiazine class, which is well-known for its applications in pharmaceuticals and agrochemicals. Here are some interesting aspects that make this compound noteworthy:
- Diverse Applications: Compounds in the benzothiadiazine family are often utilized for their biological activity, particularly as antihypertensive agents and diuretics. They offer potential therapeutic benefits in cardiovascular diseases.
- Fluorinated Moiety: The presence of the trifluoroethyl group in this compound significantly influences its chemical properties. Fluorine is often introduced into compounds to enhance metabolic stability and lipophilicity, which can improve the pharmacokinetic profiles of drugs.
- Sulfonamide Functionality: As a sulfonamide, it exhibits antibiotic properties. Sulfonamides are recognized for their role in treating bacterial infections and have laid the groundwork for the development of more modern antimicrobial agents.
- Chlorine Atom: The chlorine substitution at position 6 not only affects the compound's reactivity but may also play a role in its overall molecular stability and interactions with biological targets.
- Environmental Impact: The trifluoromethyl group can pose unique environmental challenges, as many fluorinated compounds are persistent in the environment. Understanding their fate and transport is crucial in fields such as environmental chemistry.
In the realm of medicinal chemistry, 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide serves as a prime example of how intricate chemical modifications can lead to new compounds with enhanced activity and diverse applications.
Synonyms
Renese
346-18-9
Drenusil
Nephril
Politiazida
P-2525
P 2525
Politiazida [INN-Spanish]
CCRIS 6094
HSDB 850
NSC 108161
EINECS 206-468-4
NSC-108161
UNII-36780APV5N
BRN 0770371
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide
DTXSID6025939
Nephril, (+)-
36780APV5N
SWY93BD8RL
6-Chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
CHEBI:8327
DTXCID805939
2-Methyl-3-(beta,beta,beta-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-, 1,1-dioxide
6-Chloro-3,4-dihydro-2-methyl-7-sulphamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-benzo-1,2,4-thiadiazine 1,1-dioxide
NSC108161
NCGC00182076-02
Politiazida (INN-Spanish)
Drenusil; NSC 108161; Nephril; P 2525; Renese
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide, (+)-
6-chloro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
96783-10-7
CAS-346-18-9
Renese (TN)
politiazide
NEHPRIL
UNII-SWY93BD8RL
(+-)-POLYTHIAZIDE
7Q9A5WT2FR
CHEMBL1587
SCHEMBL27909
NEPHRIL, (-)-
POLYTHIAZIDE, (-)-
GTPL7274
C03AA05
C03AB05
HMS3751M11
Tox21_113137
AKOS037653999
Tox21_113137_1
DB01324
KS-1466
NCGC00182076-03
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide (8CI, 9CI)
6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
DA-56976
HY-16403
CS-0006323
NS00008710
6-CHLORO-3,4-DIHYDRO-2-METHYL-3-
C07766
D00657
EN300-18539445
SR-01000883970
Q7227099
SR-01000883970-1
WLN: T66 BSWN EM DHJ C1 D1S1XFFF HG ISZW
BRD-A15739803-001-01-0
206-468-4
2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE, 6-CHLORO-3,4-DIHYDRO-2-METHYL-3-(((2,2,2-TRIFLUOROETHYL)THIO)METHYL)-, 1,1-DIOXIDE, (-)-
2H-1,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-, 1,1-dioxide
6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide
6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydrobenzo[e][1,2,4]thiadiazine-7-sulfonamide
6-chloro-2-methyl-1,1-dioxo-3-{[(2,2,2-trifluoroethyl)sulfanyl]methyl}-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
6-chloro-2-methyl-1,1-dioxo-3-{[(2,2,2-trifluoroethyl)sulfanyl]methyl}-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
6-Chloro-2-methyl-3-([(2,2,2-trifluoroethyl)sulfanyl]methyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide #
6-CHLORO-2-METHYL-3-[[(2,2,2-TRIFLUOROETHYL)SULFANYL]METHYL]-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
6-Chloro-3,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-CHLORO-3,4-DIHYDRO-2-METHYL-7-SULPHAMOYL-3-(2,2,2-TRI FLUOROETHYLTHIOMETHYL)-2H-BENZO-1,2,4-THIADIAZINE 1,1-DIOXIDE
6-CHLORO-3,4-DIHYDRO-2-METHYL-7-SULPHAMOYL-3-(2,2,2-TRIFLUOROETHYLTHIOMETHYL)2H-BENZO-1,2,4-THIADIAZINE 1,1-DIOXIDE
6-CHLORO-3,4DIHYDRO-2-METHYL-3-(((2,2,2-TRIFLUOROETHYL)THIO)METHYL)2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE, 1,1-DIOXIDE
96783-11-8
Solubility of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide
The solubility of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide, with the chemical formula C9H10ClF3N4O4S3, is influenced by various factors due to its complex structure. Understanding its solubility can be crucial for applications in pharmaceuticals and related fields. Here are some key points to consider:
In summary, the solubility of this compound is likely to be variable and could be modulated by factors such as solvent polarity, temperature, and pH. Further experimental studies would be necessary to determine quantitative solubility values and practical implications for its use.