6-Chloro-2-phenyl-1H-benzimidazole hydrate

Identification

Molecular formula

C₁₃H₉ClN₂ · H₂O

CAS number

6875-40-5

IUPAC name

6-chloro-2-phenyl-1H-benzimidazole;hydrate

State

At room temperature, 6-Chloro-2-phenyl-1H-benzimidazole hydrate is in a solid state.

Melting point (Celsius)

290.00

Melting point (Kelvin)

563.15

Boiling point (Celsius)

384.00

Boiling point (Kelvin)

657.15

General information

Molecular weight

260.70g/mol

Molar mass

260.7040g/mol

Density

1.3000g/cm³

Appearence

6-Chloro-2-phenyl-1H-benzimidazole hydrate is typically a white to off-white crystalline solid.

Comment on solubility

Solubility of 6-chloro-2-phenyl-1H-benzimidazole Hydrate

The solubility of 6-chloro-2-phenyl-1H-benzimidazole; hydrate can be influenced by several factors, including temperature, pH, and the presence of other solutes. Typically, this compound exhibits varying degrees of solubility in different solvents, which makes assessing its behavior in a solution quite interesting.

When considering its solubility:

Water: The hydrate form suggests some level of solubility in water, as the presence of water molecules can enhance solubility due to hydrogen bonding.
Organic Solvents: It may also dissolve in a range of organic solvents. Factors such as polarity become critical here; non-polar or slightly polar solvents may facilitate solubilization due to favorable interactions with the phenyl groups present in the structure.
Temperature Dependency: Generally, an increase in temperature can enhance the solubility of solids. Therefore, this compound may dissolve better at elevated temperatures compared to lower ones.

In conclusion, understanding the solubility of 6-chloro-2-phenyl-1H-benzimidazole; hydrate is essential for its application in various chemical processes and formulations. As the saying goes, "like dissolves like," and this principle is crucial for predicting how well the compound will dissolve in specific solvents.

Interesting facts

Interesting Facts about 6-Chloro-2-phenyl-1H-benzimidazole Hydrate

6-Chloro-2-phenyl-1H-benzimidazole hydrate is a fascinating compound that has sparked interest among chemists for its unique structure and potential applications. Here are some notable aspects:

Structural Significance: The compound features a benzimidazole core, which is known for its involvement in various biological activities, particularly in medicinal chemistry.
Substituents Matter: The presence of a chlorine atom at the 6-position and a phenyl group at the 2-position contributes to its chemical reactivity and influences how the compound interacts with biological targets.
Biological Activity: Compounds containing the benzimidazole framework, like this hydrate, are often investigated for their antimicrobial, antifungal, and antiparasitic properties. This makes them valuable in pharmaceutical research.
Hydration Importance: The inclusion of water molecules in its hydrate form can affect the compound's stability and solubility, which are critical factors in drug formulation and efficacy.
Research and Development: Scientists are continually exploring derivatives of benzimidazole compounds for potential use in treating conditions such as cancer and infections, making this compound relevant in ongoing medicinal research.

As noted chemist Albert Hofmann once said, "Science is a way of trying not to fool yourself." The study of 6-chloro-2-phenyl-1H-benzimidazole hydrate exemplifies this, as researchers aim to uncover the true potential of such compounds while adhering to rigorous scientific principles.

This compound not only showcases the beauty of organic chemistry but also the interconnectedness of structure and function in drug design, illustrating how slight modifications can lead to significant changes in biological activity.

Synonyms

1H-BENZIMIDAZOLE, 5-CHLORO-2-PHENYL-, HYDRATE

5-Chloro-2-phenyl-1H-benzimidazole hydrate

DTXSID40197746

DTXCID00120237

6-chloro-2-phenyl-1H-benzimidazole;hydrate