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Clonidine hydrochloride

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Identification
Molecular formula
C18H16Cl2N5O3
CAS number
4205-91-8
IUPAC name
6-chloro-3-(2-piperidin-1-ium-1-ylethyl)-1,3-benzoxazol-2-one;chloride
State
State

At room temperature, clonidine hydrochloride is a solid. It is commonly handled as a powder for pharmaceutical formulation.

Melting point (Celsius)
275.00
Melting point (Kelvin)
548.15
Boiling point (Celsius)
258.00
Boiling point (Kelvin)
531.15
General information
Molecular weight
266.55g/mol
Molar mass
266.5460g/mol
Density
1.2900g/cm3
Appearence

Clonidine hydrochloride commonly appears as a white to off-white crystalline powder. It is odorless and is hygroscopic, meaning it can absorb moisture from the environment.

Comment on solubility

Solubility of 6-chloro-3-(2-piperidin-1-ium-1-ylethyl)-1,3-benzoxazol-2-one;chloride

The solubility of 6-chloro-3-(2-piperidin-1-ium-1-ylethyl)-1,3-benzoxazol-2-one;chloride can be discussed with a focus on a few key factors.

  • Solvent Type: This compound is likely to be soluble in polar solvents due to its ionic nature, primarily stemming from the piperidinium moiety. Common polar solvents include:
    • Water
    • DMSO (Dimethyl sulfoxide)
    • Ethanol
  • Temperature Influence: As with many compounds, increasing the temperature may enhance solubility. This can be particularly advantageous when working with this compound in various experimental conditions.
  • pH Levels: The solubility could also be influenced by the pH of the solution. The presence of the piperidinium group indicates that it may be more soluble in acidic conditions where the compound remains protonated.
  • Complex Formation: It is worth noting that the potential to form complexes with different ions may also affect solubility, especially in biological systems.

In summary, while specific quantitative solubility data may vary, it can often be inferred that 6-chloro-3-(2-piperidin-1-ium-1-ylethyl)-1,3-benzoxazol-2-one;chloride is expected to show substantial solubility in polar solvents, especially under favorable temperature and pH conditions.

Interesting facts

Overview of 6-Chloro-3-(2-piperidin-1-ium-1-ylethyl)-1,3-benzoxazol-2-one; Chloride

6-Chloro-3-(2-piperidin-1-ium-1-ylethyl)-1,3-benzoxazol-2-one; chloride is a fascinating compound that draws attention in the fields of medicinal chemistry and pharmacology. Its complex structure suggests intriguing interactions and potential applications.

Key Interesting Facts

  • Structural Significance: The presence of both a benzoxazole ring and a piperidine moiety in its structure indicates the compound's potential as a lead molecule in drug discovery, particularly in the development of agents targeting neurological disorders.
  • Ionizable Functional Group: The piperidin-1-ium group indicates that the compound can exist as a zwitterion, giving it unique properties that may enhance its biological activity.
  • Chlorine Atom: The inclusion of a chlorine atom can significantly influence the compound's reactivity and selectivity in biological systems, often enhancing lipophilicity and improving the interaction with biological targets.
  • Potential Applications: Research into similar benzoxazole derivatives has shown promise in anti-cancer, anti-inflammatory, and anti-viral activities, paving the way for exploring this compound's therapeutic potential.
  • Research Utilization: Compounds like this are often synthesized for use in synthesis pathways that aim to create bigger, more complex molecules in pharmaceutical research, highlighting the intricate dance of structure-activity relationships in drug development.

Furthermore, scientists are constantly exploring the biological mechanisms of such compounds, aiming to understand how small changes in their structure can lead to significant variations in their pharmacological profiles. As studies continue, the potential for this compound to play a role in innovative therapies remains vast and exciting.

Synonyms
6-Chloro-3-(2-piperidinoethyl)-2-benzoxazolinone hydrochloride
2-BENZOXAZOLINONE, 6-CHLORO-3-(2-PIPERIDINOETHYL)-, MONOHYDROCHLORIDE
14627-26-0