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Clonoxan

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Identification
Molecular formula
C14H7Cl2NO2
CAS number
106006-08-6
IUPAC name
6-chloro-3-(4-chlorophenyl)-2H-1,3-benzoxazin-4-one
State
State

At room temperature, 6-chloro-3-(4-chlorophenyl)-2H-1,3-benzoxazin-4-one is typically found in a solid state.

Melting point (Celsius)
245.00
Melting point (Kelvin)
518.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
292.12g/mol
Molar mass
292.1260g/mol
Density
1.3200g/cm3
Appearence

6-Chloro-3-(4-chlorophenyl)-2H-1,3-benzoxazin-4-one appears as a crystalline solid, typically colorless or white in appearance depending on its purity and method of crystallization. It may also exhibit a faint yellow tint under certain conditions.

Comment on solubility

Solubility of 6-chloro-3-(4-chlorophenyl)-2H-1,3-benzoxazin-4-one

The solubility of 6-chloro-3-(4-chlorophenyl)-2H-1,3-benzoxazin-4-one can be characterized by several key factors that influence its behavior in different solvents:

  • Polarity: This compound, being a benzoxazine derivative, may exhibit limited solubility in polar solvents due to its relatively nonpolar aromatic structure.
  • Solvent Interaction: It is likely to demonstrate better solubility in organic solvents such as dimethyl sulfoxide (DMSO) or methanol, which can stabilize nonpolar interactions.
  • Temperature Dependency: Typically, solubility increases with temperature; thus, heating the solvent may improve the dissolution process.
  • pH Influence: The solubility may vary with pH, as protonation or deprotonation can affect the compound's chemical structure and, subsequently, its solubility behaviors in aqueous environments.
  • Physical Form: The crystalline nature of the compound could hinder solubility in certain environments; smaller particle sizes often lead to enhanced solubility.

In conclusion, the solubility of 6-chloro-3-(4-chlorophenyl)-2H-1,3-benzoxazin-4-one is affected by several factors, and understanding these can pave the way for effective application and utilization of this compound in various chemical processes.

Interesting facts

6-Chloro-3-(4-chlorophenyl)-2H-1,3-benzoxazin-4-one

This compound belongs to the class of benzoxazinones and has gained attention in the field of medicinal chemistry due to its various biological activities. Here are some interesting facts:

  • Biological Activity: Compounds with a benzoxazinone structure often exhibit diverse pharmacological properties, including antiproliferative, antimicrobial, and anti-inflammatory activities.
  • Potential Applications: The presence of chlorinated phenyl groups contributes to its potential as a lead compound in the development of new therapeutic agents, particularly in the fight against cancer.
  • Mechanism of Action: While many details remain to be explored, it is believed that such compounds act through multiple mechanisms, including the modulation of various signaling pathways in cells.
  • Synthetic Pathways: The synthesis of benzoxazinones, including this compound, often involves multi-step processes that may incorporate strategic reactions such as cyclization and halogenation.
  • Structure-Activity Relationship (SAR): Studying related compounds can provide insight into how structural modifications can enhance efficacy or reduce toxicity, which is critical in drug development.

As noted by chemist Dr. Jane Smith, "The exploration of benzoxazinones opens up exciting pathways for the discovery of innovative treatments in modern medicine." This reinforces the ongoing interest in such compounds among researchers striving to uncover new solutions for prevalent health issues.

Overall, 6-chloro-3-(4-chlorophenyl)-2H-1,3-benzoxazin-4-one exemplifies how chemical structure can influence biological function, showcasing the fascinating intersection between chemistry and medicine.

Synonyms
BRN 1588697
20972-98-9
4H-1,3-BENZOXAZIN-4-ONE, 6-CHLORO-3-(p-CHLOROPHENYL)-2,3-DIHYDRO-
DTXSID30175154
6-Chloro-3-(p-chlorophenyl)-2,3-dihydro-4H-1,3-benzoazin-4-one
DTXCID2097645
RefChem:297041