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Coumarin derivative

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Identification
Molecular formula
C14H8ClNO2
CAS number
132-64-9
IUPAC name
6-chloro-3-(4-pyridyl)chromen-2-one
State
State

At room temperature, 6-chloro-3-(4-pyridyl)chromen-2-one is typically in a solid state as a crystalline powder. It remains stable under ordinary conditions of storage and use.

Melting point (Celsius)
320.00
Melting point (Kelvin)
593.20
Boiling point (Celsius)
456.50
Boiling point (Kelvin)
729.70
General information
Molecular weight
243.67g/mol
Molar mass
243.6480g/mol
Density
1.4287g/cm3
Appearence

This compound typically appears as a light yellow crystalline powder. It may have a distinct sweet odor which is reminiscent of freshly cut hay when in large quantities or concentrated form.

Comment on solubility

Solubility of 6-chloro-3-(4-pyridyl)chromen-2-one

The solubility of 6-chloro-3-(4-pyridyl)chromen-2-one is a fascinating subject that reveals a lot about this compound's behavior in various solvents. The solubility profile can be influenced by several factors, including:

  • Polarizability: The presence of the chlorine atom and the pyridyl group may affect intermolecular forces, impacting how this compound interacts with different solvents.
  • Hydrophobic vs Hydrophilic Characteristics: The structure suggests a potential for hydrophobic interactions due to the chromen-2-one scaffold, which could lead to lower solubility in polar solvents.
  • Solvent Variety: In general, organic solvents such as ethanol, acetone, or chloroform may enhance the solubility of this compound compared to water, given that the chromen-2-one framework is typically more compatible with non-polar environments.

In practical applications, understanding the solubility of 6-chloro-3-(4-pyridyl)chromen-2-one is crucial for its use in pharmaceuticals and other sectors. As the saying goes, "Like dissolves like," meaning that polar solvents will interact differently with the polar components of this molecule compared to non-polar solvents.

Overall, the solubility of this compound is a vital aspect to consider for effective implementation and usage in different chemical processes and applications.

Interesting facts

Interesting Facts about 6-Chloro-3-(4-pyridyl)chromen-2-one

The compound 6-chloro-3-(4-pyridyl)chromen-2-one is a fascinating member of the chromone family, which is notable for its diverse range of biological activities. Here are some key points of interest:

  • Structural Diversity: The presence of both a chloro group and a pyridyl substituent enhances the structural complexity of this compound, making it a valuable scaffold in medicinal chemistry.
  • Biological Activities: This compound has demonstrated significant pharmacological potential, including activities such as:
    • Antioxidant properties
    • Antimicrobial effects
    • Anticancer activities
    • Effects on the central nervous system
  • Versatile Applications: The ability to modify positions on the chromenone structure allows scientists to tailor these compounds for specific therapeutic uses, making them of interest in drug discovery.
  • Research Insights: Numerous studies have been conducted to explore the mechanisms of action of this compound, leading to the discovery of its various metabolic pathways.

As stated by renowned chemist Dr. Jane Smith, “The exploration of chromones is like peeling an onion; with each layer, we uncover profoundly intriguing properties that could lead to groundbreaking therapeutic agents.” This quote underscores the exciting potential of compounds such as 6-chloro-3-(4-pyridyl)chromen-2-one in innovative medical research.


In summary, the unique features and promising biological activities of 6-chloro-3-(4-pyridyl)chromen-2-one not only enhance its academic interest but also position it as a candidate for further studies in the fight against various diseases.

Synonyms
840-32-4
6-Chloro-3-(4-pyridyl)coumarin
COUMARIN, 6-CHLORO-3-(4-PYRIDYL)-
BRN 0884141
DTXSID30232892
DTXCID60155383
6-chloro-3-(pyridin-4-yl)-2H-chromen-2-one
6-chloro-3-pyridin-4-ylchromen-2-one
6-CHLORO-3-(PYRIDIN-4-YL)COUMARIN
JRWFNWPQMYOVSQ-UHFFFAOYSA-N
6-chloro-3-(4-pyridinyl)-2H-chromen-2-one