Interesting facts
Interesting Facts about 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide
This intricate compound belongs to a class of chemicals known as sulfonamides, which are often employed in medicinal chemistry due to their antibacterial properties. Here are some fascinating aspects of this specific compound:
- Multifunctional Structure: The compound features a unique structure characterized by the presence of both a chloro and a chloromethyl group. This lends itself to a variety of chemical reactions, making it a versatile building block in synthesis.
- Medical Applications: Compounds that share similar structural features are frequently studied for their potential therapeutic effects, particularly as antibiotics or anti-inflammatory agents.
- Environmental Impact: Sulfonamides like this one have been investigated for their persistence in the environment and their effects on aquatic life, raising important questions about their ecological footprint.
- Research Potential: The presence of multiple functional groups in this compound opens avenues for research on its reactivity and interactions with biological systems, providing chemists exciting challenges in drug discovery.
- Historical Significance: Sulfonamides were among the first modern antibacterial drugs, marking a significant advance in the field of medicine and paving the way for the development of more complex antibiotics.
As we delve deeper into the study of this compound, we not only uncover its chemical properties but also its potential role in enhancing human health and understanding environmental chemistry.
Synonyms
methyclothiazide
135-07-9
Enduron
Aquatensen
Methyclothiazid
Duretic
Methycyclothiazide
Enduronum
Methychlothiazide
METHYLCLOTHIAZIDE
Methylcyclothiazide
Methylchlorothiazide
Ciba 7272-Su
Meticlotiazida
Aquaresen
Meticlotiazide
Methyclothiazidum
NSC-110431
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide
Meticlotiazida [INN-Spanish]
Methyclothiazidum [INN-Latin]
NSC 110431
HSDB 3363
Aquatensen;Enduron
EINECS 205-172-2
UNII-L3H46UAC61
CI-625
BRN 0765361
L3H46UAC61
6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
DTXSID6023313
Methyclothiazide, (+)-
Methyclothiazide, (-)-
6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
NSC110431
R00UUL4SRN
R6KDH2S0SX
MLS002704228
CHEBI:6847
DTXCID403313
6-Chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
96783-15-2
EUTRON COMPONENT METHYCLOTHIAZIDE
Naturon (VAN)
NCGC00167446-01
ENDURONYL COMPONENT METHYCLOTHIAZIDE
Methyclothiazide [USAN:USP:INN:BAN:JAN]
DIUTENSEN-R COMPONENT METHYCLOTHIAZIDE
Meticlotiazide [DCIT]
2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide
6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Meticlotiazida (INN-Spanish)
Methyclothiazidum (INN-Latin)
METHYCLOTHIAZIDE (MART.)
METHYCLOTHIAZIDE [MART.]
METHYCLOTHIAZIDE (USP-RS)
METHYCLOTHIAZIDE [USP-RS]
METHYCLOTHIAZIDE (USP MONOGRAPH)
METHYCLOTHIAZIDE [USP MONOGRAPH]
(+/-)-6-CHLORO-3-(CHLOROMETHYL)-3,4-DIHYDRO-2-METHYL-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide, (+)-
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide, (-)-
96783-14-1
CAS-135-07-9
Enduron (TN)
Methyclothiazide (USAN:USP:INN:BAN:JAN)
Methyclothiazide (JAN/USP/INN)
UNII-R00UUL4SRN
UNII-R6KDH2S0SX
Methyclothiazide (Standard)
CHEMBL1577
SCHEMBL49396
METHYCLOTHIAZIDE [MI]
(+-)-6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
METHYCLOTHIAZIDE [INN]
METHYCLOTHIAZIDE [JAN]
METHYCLOTHIAZIDE [HSDB]
METHYCLOTHIAZIDE [USAN]
GTPL7235
METHYCLOTHIAZIDE [VANDF]
HY-B0562R
C03AA08
METHYCLOTHIAZIDE [WHO-DD]
HMS3264D19
HMS3652E06
Pharmakon1600-01503841
HY-B0562
Tox21_112450
NSC760078
s4057
METHYCLOTHIAZIDE [ORANGE BOOK]
AKOS015896465
Tox21_112450_1
CCG-213705
DB00232
KS-5138
NSC-760078
6-chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide
NCGC00167446-02
NCGC00167446-03
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide, (+-)-
6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2, 4-benzothiadiazine-7-sulfonamide 1,1-dioxide
AS-12982
DA-75460
SMR001550236
METHYCLOTHIAZIDE COMPONENT OF EUTRON
NS00010492
SW219271-1
METHYCLOTHIAZIDE COMPONENT OF ENDURONYL
C07765
D00656
EN300-122353
G12545
SBI-0653400.0001
WLN: T66 BSWN EM DHJ C1 D1G HG ISZW
AB01014600_03
AB01014600_04
METHYCLOTHIAZIDE COMPONENT OF DIUTENSEN-R
A806880
Q6823919
BRD-A95340155-001-05-5
BRD-A95340155-001-09-7
Z1541759222
6-Chloro-3-(chloromethyl)-3,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
205-172-2
2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE, 6-CHLORO-3-(CHLOROMETHYL)-3,4-DIHYDRO-2-METHYL-, 1,1-DIOXIDE, (+/-)-
2H-1,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide
6-chloranyl-3-(chloromethyl)-2-methyl-1,1-bis(oxidanylidene)-3,4-dihydro-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
6-Chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide #
Solubility of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide
The solubility of the compound 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide (C7H8ClN3O4S2) can be influenced by several factors, including chemical structure, temperature, and solvent choice. Generally, compounds containing sulfonamide groups tend to be polar, which may enhance their solubility in polar solvents such as water. However, certain functional groups, like chlorine atoms, can introduce hydrophobic characteristics that might limit solubility in highly polar environments.
Key points to consider regarding the solubility of this compound include:
In summary, while 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide may display moderate solubility due to its sulfonamide structure, the presence of halogens could influence its overall behavior in different solvents.