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Chlorothiazide

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Identification
Molecular formula
C7H6ClN3O4S2
CAS number
58-94-6
IUPAC name
6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
State
State

At room temperature, Chlorothiazide is in a solid state.

Melting point (Celsius)
355.00
Melting point (Kelvin)
628.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
295.72g/mol
Molar mass
295.7200g/mol
Density
1.8100g/cm3
Appearence

Chlorothiazide is typically a white or almost white crystalline powder. It is practically insoluble in water, soluble in acetone, and sparingly soluble in ethanol.

Comment on solubility

Solubility of 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

The solubility of a compound can greatly influence its applications within various fields, especially in pharmaceuticals and environmental science. For the compound 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide (C7H6ClN3O4S2), a few key points regarding its solubility can be outlined:

  • Polarity: The presence of a sulfonamide group enhances the polarity of the molecule, potentially aiding in its solubility in polar solvents such as water.
  • Hydrophobic Interactions: The cyclopentylmethyl moiety may introduce hydrophobic characteristics, which could limit solubility in polar solvents, but might increase solubility in organic solvents.
  • pH Dependence: The solubility of this compound may also vary with pH, as the sulfonamide group can participate in hydrogen bonding and charge interactions depending on the acidic or basic conditions.

In conclusion, the solubility of 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide is influenced by both its structure and the solvent characteristics. Understanding these factors is crucial for predicting its behavior in various environments.

Interesting facts

Interesting Facts about 6-Chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

This remarkable compound belongs to a class of chemicals known as sulfonamides, which have a rich history and important applications in medicinal chemistry. Below are some intriguing aspects of this compound that highlight its significance:

  • Pharmacological Potential: Sulfonamides like this compound have played a crucial role in the development of antibiotics. The ability of sulfonamides to inhibit bacterial growth highlights their importance in medicinal applications.
  • Diverse Structure: The intricate structure of this compound showcases how modifying benzothiadiazine derivatives can lead to variations in biological activity. The presence of the cyclopentylmethyl group could influence its lipophilicity and interaction with biological targets.
  • Applications in Drug Design: Compounds with similar structures are often explored for their potential as anti-inflammatory agents and diuretics, illustrating the compound's relevance in drug development studies.
  • Innovation in Chemistry: The synthesis of complex molecules such as this one is a testament to the advancements in organic and medicinal chemistry. The methodologies developed for creating such compounds contribute to the ever-evolving field of pharmaceuticals.

As we delve deeper into the properties and the mechanisms of action of this compound, it's fascinating to think about the potential discoveries that lie ahead. The ongoing exploration in the realm of chemical compounds like this one continues to inspire innovation and research in the world of science.

Synonyms
cyclopenthiazide
742-20-1
Cyclomethiazide
Benesal
Navidrex
Cyclometiazid
Cyclopentiazid
Navidreks
Salimed
Salimid
Ultra-Minzil
Salurilo-C
Tsiklometiazid
Navidrix
Ciba 8341-Su
Ciclopentiazida
Su-8341
Ciclopentiazide
SU 8341
Cyclopenthiazidum
Navidrex K
6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Ciclopentiazide [DCIT]
NSC-107679
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide
3-Cyclopentylmethyl hydrochlorothiazide deriv
Navidrex (TN)
NSC 107679
Ciclopentiazida [INN-Spanish]
Cyclopenthiazidum [INN-Latin]
VX4S2N85F5
(+)-Cyclopenthiazide
(-)-Cyclopenthiazide
DTXSID4022868
8341-Su
Cyclopenthiazide, (+)-
Cyclopenthiazide, (-)-
2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide
EINECS 212-012-5
NSC107679
Cyclopenthiazide [USAN:INN:BAN:JAN]
BRN 0630346
CYCLOPENTHIAZIDE [MI]
CYCLOPENTHIAZIDE [INN]
CYCLOPENTHIAZIDE [JAN]
CYCLOPENTHIAZIDE [USAN]
MLS000737270
DTXCID802868
CYCLOPENTHIAZIDE [MART.]
CYCLOPENTHIAZIDE [WHO-DD]
866GEV195O
T7817XC41U
6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
96783-06-1
Ciclopentiazida (INN-Spanish)
Cyclopenthiazidum (INN-Latin)
CYCLOPENTHIAZIDE (MART.)
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide, (+)-
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide, (-)-
6-chloro-3-(cyclopentylmethyl)-1,1-diketo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
96783-05-0
UNII-VX4S2N85F5
NCGC00016534-01
6-chloro-3-(cyclopentylmethyl)-1,1-diketo-3,4-dihydro-2H-1$l^(6),2,4-benzothiadiazine-7-sulfonamide
6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-benzo(e)(1,2,4)thiadiazine-7-sulfonamide
CAS-742-20-1
Cyclopenthiazide,(S)
Prestwick0_000994
Prestwick1_000994
Prestwick2_000994
Prestwick3_000994
Cyclopenthiazide (Standard)
SCHEMBL49142
BSPBio_001087
UNII-866GEV195O
UNII-T7817XC41U
SPBio_002978
BPBio1_001197
GTPL7899
Tsiklometiazid (cyclomethiazide)
CHEMBL1373254
CHEBI:91686
C03AA07
Cyclopenthiazide (JAN/USAN/INN)
HMS1571G09
HMS2098G09
HMS2886L05
HMS3715G09
BCP24493
Tox21_110481
MFCD00865825
AKOS024462515
Tox21_110481_1
CCG-220994
DB13532
HY-109542R
6-Chloro-3-cyclopentylmethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide
NCGC00179312-03
6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
BS-48942
DA-72482
SMR000528497
HY-109542
AB00513990
CS-0031283
NS00006210
D02061
E78748
EN300-18562604
SR-01000776288
WLN: T66 BSWM EM DHJ HG ISZW D1- AL5TJ
Q3676519
SR-01000776288-2
BRD-A41250306-001-03-4
BRD-A41250306-001-11-7
6-Chloro-3-(cyclopentylmethyl)-3,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
212-012-5
2H-1,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide
2H-1,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-,1,1-dioxide