Skip to main content

Chlorothiazide

ADVERTISEMENT
Identification
Molecular formula
C7H6ClN3O4S2
CAS number
58-94-6
IUPAC name
6-chloro-3-ethyl-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
State
State

Chlorothiazide is a solid at room temperature. It is typically available in the form of tablets or powder for medical formulation purposes.

Melting point (Celsius)
350.00
Melting point (Kelvin)
623.15
Boiling point (Celsius)
306.00
Boiling point (Kelvin)
579.15
General information
Molecular weight
295.72g/mol
Molar mass
295.7200g/mol
Density
1.8200g/cm3
Appearence

Chlorothiazide appears as a white or almost white, crystalline powder. It is often described as having very small, fine particles and can appear slightly off-white depending on certain conditions or purity levels.

Comment on solubility

Solubility of 6-chloro-3-ethyl-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide

The solubility of 6-chloro-3-ethyl-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide is a complex topic, influenced by its unique molecular structure and functional groups. Generally, solubility can be affected by several factors:

  • Polarity: The presence of sulfonamide and dioxo groups suggests a certain degree of polarity, which may enhance solubility in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water molecules can increase solubility; therefore, the presence of functional groups that can participate in hydrogen bonding may be advantageous.
  • Solvent Interaction: Solubility can vary significantly depending on the solvent used. For example, it may dissolve better in water or dimethyl sulfoxide (DMSO) than in hydrocarbons.

Experimental data is crucial to accurately determine solubility, as theoretical predictions may not capture all interactions present in solid-state or when mixed with different solvents. It is often stated that "solubility is a property that is greatly influenced by environmental factors" which highlights the need for empirical studies. As such, considering these parameters along with the specific context of the solubility study is essential for understanding how well this compound can dissolve in various media.

Interesting facts

Interesting Facts about 6-chloro-3-ethyl-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide

This multifaceted compound represents a fascinating intersection of organic chemistry and pharmacology:

  • Structural Complexity: The structure of this compound features a benzothiadiazine core, which contributes to its intriguing chemical properties and potential biological activities.
  • Chlorine Substitution: The presence of the 6-chloro group is notable as it can significantly influence the reactivity and pharmacokinetic profile of the molecule.
  • Sulfonamide Functionality: This compound contains a sulfonamide group, which is known for its use in the development of antimicrobial agents. Sulfonamides were one of the first antibiotics and paved the way for modern medicinal chemistry.
  • Pharmacological Potential: Research indicates that derivatives of benzothiadiazines can exhibit a range of biological activities, including anti-inflammatory and diuretic effects.
  • Versatile Applications: Compounds like this one can be explored for use in various therapeutic areas, including cardiovascular health, cancer treatment, and as antihypertensives.

“Innovative compounds such as this challenge our understanding of chemical interactions and encourage the exploration of their applications in medicine.”
As scientists continue to explore the potential of this compound, the synthesis of derivatives and modifications holds promise for future discoveries in therapeutic chemistry.

Synonyms
ETHIAZIDE
1824-58-4
Salta
Etiazida
7-CHLORO-2-ETHYL-4,4-DIOXO-1,2,3-TRIHYDRO-4-THIAQUINAZOLINE-6-SULFONAMIDE
EK9LSW731R
Hypertane
6-chloro-3-ethyl-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Eclotizidum
DTXSID1046215
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-ethyl-3,4-dihydro-, 1,1-dioxide
NCGC00160540-01
Aethiazidum
Neo-diuresal
6-Chloro-3-ethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Etiazide [DCIT]
DTXCID9026215
Ethiazidum
Etiazide
Ethiazidum [INN-Latin]
Etiazida [INN-Spanish]
3-Ethylhydrochlorothiazide
Ethiazide [INN:BAN:JAN]
CAS-1824-58-4
EINECS 217-358-0
UNII-EK9LSW731R
Acthiazidum
MFCD00867314
Ethiazide (JAN/INN)
ETHIAZIDE [INN]
ETHIAZIDE [JAN]
ETHIAZIDE [MI]
ETHIAZIDE [WHO-DD]
SCHEMBL122238
CHEMBL2106262
CHEBI:31566
Tox21_111883
AKOS022168498
Tox21_111883_1
NCGC00160540-02
NCGC00160540-03
MS-10361
HY-120147
CS-0077019
NS00010484
D01247
SR-01000883685
SR-01000883685-1
Q27277223
6-CHLORO-3-ETHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE-1,1-DIOXIDE
6-chloro-3-ethyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide