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Chlorothiazide

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Identification
Molecular formula
C7H6ClN3O4S2
CAS number
58-94-6
IUPAC name
6-chloro-3-isobutyl-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
State
State

At room temperature, Chlorothiazide is typically in the form of a solid, specifically a crystalline powder.

Melting point (Celsius)
344.00
Melting point (Kelvin)
617.15
Boiling point (Celsius)
380.60
Boiling point (Kelvin)
653.80
General information
Molecular weight
295.72g/mol
Molar mass
295.7210g/mol
Density
1.6300g/cm3
Appearence

Chlorothiazide appears as a white to almost white crystalline powder.

Comment on solubility

Solubility of 6-chloro-3-isobutyl-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

The solubility of 6-chloro-3-isobutyl-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide can exhibit notable characteristics depending on various factors such as the solvent and temperature. Here are some key points to consider:

  • Water Solubility: Typically, sulfonamides are known for their moderate to high solubility in water due to the presence of sulfonamide groups which can engage in hydrogen bonding.
  • Polar Solvents: Compounds similar in structure often demonstrate increased solubility in polar solvents, potentially allowing for effective dissolution in alcohols or dimethyl sulfoxide (DMSO).
  • Temperature Dependence: The solubility of this compound may vary with temperature, generally increasing with rising temperatures, thus enhancing the potential for therapeutic applications.
  • pH Influence: The solubility can also be affected by the pH of the solution, with a more acidic environment potentially increasing the solubility due to protonation of functional groups.

It's important to remember that specific solubility data for this compound may vary, and experimental analysis is always recommended to confirm theoretical predictions.

In conclusion, exploring the solubility profile of this complex compound can provide valuable insights into its potential utility in various chemical and pharmaceutical applications.

Interesting facts

Interesting Facts about 6-Chloro-3-isobutyl-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide

This compound, known for its structural complexity, belongs to the class of benzothiadiazine sulfonamides, which are significant in medicinal chemistry. Here are some intriguing points worth noting:

  • Pharmaceutical Relevance: Compounds like this one are often studied for their potential use as diuretics, showcasing their ability to influence kidney function and fluid balance in the body.
  • Mechanism of Action: It is believed that the sulfonamide group within the compound plays a crucial role in its biological activities, often interacting with enzymes essential for various metabolic processes.
  • Diverse Applications: Researchers explore derivatives of this compound for various therapeutic effects, including antihypertensive and anti-inflammatory properties.
  • Structural Diversity: The presence of the chloro and isobutyl groups contributes to its unique pharmacological profile and can affect the compound's reactivity and interaction with biological targets.
  • Environmental and Synthetic Interest: The synthesis of this compound provides valuable insight into the development of new methodologies in organic synthesis, often requiring innovative approaches to create specific functional groups.

In summary, 6-chloro-3-isobutyl-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide represents a fascinating intersection of organic chemistry and pharmacology, offering a multitude of possibilities for future research and application in therapeutic contexts. As scientists continue to unveil its functionalities, this compound reinforces the core principle of chemistry that complexity often parallels utility.

Synonyms
BUTHIAZIDE
Butizide
thiabutazide
Eunephran
isobutylhydrochlorothiazide
Saltucin
Buthiazide [USAN]
Butizidum [INN-Latin]
Butizida [INN-Spanish]
Butizide [INN]
UNII-W00SSD35VW
EINECS 218-048-8
W00SSD35VW
Butizide (INN)
Buthiazide (USAN)
SU 6187
BUTHIAZIDE [MI]
S 3500
BUTIZIDE [MART.]
BUTIZIDE [WHO-DD]
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(2-methylpropyl)-, 1,1-dioxide
6-Chloro-3,4-dihydro-3-isobutyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
DTXSID6022713
6-Chloro-3,4-dihydro-3-isobutyl-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
Butizidum (INN-Latin)
Butizida (INN-Spanish)
BUTIZIDE (MART.)
hydrochlorbuthiazide
DTXCID102713
2043-38-1
Butizida
Buthiazide-d10(Major)
Butizid
Butizidum
6-chloro-3-isobutyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
SCHEMBL309110
CHEMBL2104197
CHEBI:135492
HGBFRHCDYZJRAO-UHFFFAOYSA-N
EX-A6686
AKOS040750939
FB19384
6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-1|E6,2,4-benzothiadiazine-7-sulfonamide
6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
DB-242747
HY-119557
CS-0069749
NS00009381
D03189
Q5002531
6-Chloro-3,4-dihydro-3-(2-methylpropyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;Butizid;Butizide
6-Chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
6-chloro-3-(2-methylpropyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide