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6-Chloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C8H3ClF3N3O2
CAS number
20537-98-0
IUPAC name
6-chloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, this compound exists in a solid state. It is often stored in tightly sealed containers to maintain its stability and prevent degradation over time.

Melting point (Celsius)
128.00
Melting point (Kelvin)
401.15
Boiling point (Celsius)
251.00
Boiling point (Kelvin)
524.15
General information
Molecular weight
265.57g/mol
Molar mass
265.5700g/mol
Density
1.6700g/cm3
Appearence

6-Chloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole typically appears as a crystalline solid with a pale yellow to off-white color.

Comment on solubility

Solubility of 6-chloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 6-chloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole in various solvents exhibits notable characteristics that reflect its chemical structure. Due to the presence of multiple functional groups, the solubility can be influenced by:

  • Polarity: The presence of polar groups, such as the nitro and chloro substituents, can enhance solubility in polar solvents, while the trifluoromethyl group may contribute to hydrophobic interactions.
  • Hydrogen Bonding: The ability to form hydrogen bonds can significantly increase solubility in suitable solvents, particularly in alcohols and dimethyl sulfoxide (DMSO).
  • Temperature Effects: Solubility often increases with temperature, which needs to be considered during experiments or applications.

It is important to note that:

  • The compound may have low solubility in non-polar solvents due to a predominance of hydrophobic characteristics.
  • The solubility behavior needs to be tested in specific solvents for accurate data collection.

As a general observation, assessing solubility through methods such as solvent screening or examining structural interactions can provide deeper insights. Understanding the solubility profile is crucial for applications in pharmaceutical formulations where effective delivery of drugs often depends on the solubility of the active compounds.

Interesting facts

Interesting Facts about 6-Chloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole

6-Chloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound within the realm of organic chemistry, particularly for its diverse applications and unique structural features. Here are some noteworthy aspects:

  • Structural Complexity: The compound belongs to the benzimidazole family, which is known for its fused ring system that confers interesting chemical and biological properties.
  • Fluorine Influence: The incorporation of a trifluoromethyl group makes this compound highly lipophilic, enhancing its biological activity and influencing its interactions with other molecules.
  • Biological Relevance: Compounds featuring benzimidazole derivatives have been studied for their potential in pharmaceuticals, particularly for their anti-parasitic and anti-cancer properties. This compound could play a role in targeted drug design.
  • Mechanistic Insights: The electron-withdrawing groups, such as the nitro and chloro substituents, can affect the reactivity of the benzimidazole nucleus, possibly leading to interesting chemical behaviors in various reactions.
  • Potential Applications: Due to its unique properties, this compound is being explored in various fields, including agrochemicals and medicine, for applications such as herbicides, insecticides, and medication.

In summary, 6-chloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole is more than just a chemical entity; it is a bridge to understand the intersections of structure, reactivity, and application in science. As stated by renowned chemists, "The study of complex molecules like this one leads to breakthroughs that can change the world." Embracing its intricacies may provide future opportunities for innovative research and development.

Synonyms
3671-18-9
BENZIMIDAZOLE, 6-CHLORO-4-NITRO-2-(TRIFLUOROMETHYL)-
6-Chloro-4-nitro-2-(trifluoromethyl)benzimidazole
Benzimidazole, 4-nitro-6-chloro-2-(trifluoromethyl)-
DTXSID10190168
DTXCID20112659
6-chloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole
SCHEMBL8855571
STOJWTVNHAJLBI-UHFFFAOYSA-N