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Clofibric acid derivative

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Identification
Molecular formula
C20H13ClN4O4S
CAS number
100490-36-8
IUPAC name
6-chloro-4-oxo-N-[4-(2-pyridylsulfamoyl)phenyl]chromene-2-carboxamide
State
State

At room temperature, this compound is typically in a solid state. It can exist as a powder or crystalline solid depending on its purity and form.

Melting point (Celsius)
225.00
Melting point (Kelvin)
498.10
Boiling point (Celsius)
595.15
Boiling point (Kelvin)
868.30
General information
Molecular weight
434.87g/mol
Molar mass
434.8720g/mol
Density
1.5300g/cm3
Appearence

The compound appears as a solid powder that is often off-white or beige in color. It may also appear as crystalline in form depending on the specific purification and synthesis method used. The texture and granularity can vary based on crystal size and form.

Comment on solubility

Solubility of 6-chloro-4-oxo-N-[4-(2-pyridylsulfamoyl)phenyl]chromene-2-carboxamide

The solubility of 6-chloro-4-oxo-N-[4-(2-pyridylsulfamoyl)phenyl]chromene-2-carboxamide can be characterized by several factors influencing its behavior in different solvents. Typically, solubility is contingent upon the following parameters:

  • Polarity of Solvent: A compound's solubility often depends on the polarity of the solvent. This molecule contains both polar and non-polar functional groups, suggesting good solubility in polar protic solvents such as water or methanol.
  • Hydrogen Bonding: The presence of carboxamide groups indicates potential for hydrogen bonding with solvents, enhancing its solubility in polar environments.
  • pH Influence: The ionization of carboxamide groups at varying pH levels may impact solubility, where increased pH can lead to enhanced solvation.
  • Temperature Effect: Solubility may increase with temperature due to higher kinetic energy, aiding in dissolution.
  • Crystal Lattice Energy: A strong crystal lattice may reduce solubility, necessitating specific solvent conditions to disrupt solid-state interactions.

In summary, while specific quantitative solubility data on 6-chloro-4-oxo-N-[4-(2-pyridylsulfamoyl)phenyl]chromene-2-carboxamide may be limited, it is anticipated that its unique structure allows for solubility in polar solvents, influenced significantly by hydrogen bonding capabilities and environmental factors. This underscores the importance of choosing the right solvent for dissolution.

Interesting facts

Interesting Facts about 6-chloro-4-oxo-N-[4-(2-pyridylsulfamoyl)phenyl]chromene-2-carboxamide

This intriguing chemical compound belongs to the chromene family, which is known for its diverse biological activities. Here are some fascinating insights into this compound:

  • Biological Significance: Compounds like this one are often studied for their potential pharmacological activities, particularly in the domain of antitumor properties. Their complex structure may interact with various biological targets, making them a focus of research in medicinal chemistry.
  • Sulfamoyl Group: The presence of a 2-pyridylsulfamoyl group in this compound hints at interesting interactions within biological systems. Sulfamoyl groups are often associated with antibacterial properties, making them valuable in drug development.
  • Chromene Backbone: The chromene structure is a key feature in many natural products and serves as a base for synthetically derived pharmaceuticals. It contributes to fluorescence and has applications in materials science as well.
  • Research Potential: Researchers are constantly exploring compounds like this for their ability to act as enzyme inhibitors or modulators. This suggests a potential role in treating diseases such as cancer or inflammation.
  • Chlorination Influence: The chloro substituent may enhance the compound's biological activity by increasing lipophilicity, which can aid in cellular membrane penetration. The chemistry of halogens often plays a pivotal role in medicinal chemistry.

In summary, the multifaceted nature of 6-chloro-4-oxo-N-[4-(2-pyridylsulfamoyl)phenyl]chromene-2-carboxamide makes it a subject of great interest within the scientific community, especially in the realms of pharmaceuticals and biotechnology. Its rich chemistry holds promise for future discoveries!

Synonyms
BRN 0462682
27455-36-3
4H-1-BENZOPYRAN-2-CARBOXANILIDE, 6-CHLORO-4-OXO-4'-(2-PYRIDYLSULFAMOYL)-
DTXSID30181871
6-Chloro-4-oxo-4'-(2-pyridylsulfamoyl)-4H-1-benzopyran-2-carboxanilide
RefChem:297186
DTXCID70104362