6-Chloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole

Identification

Molecular formula

C₈H₃ClF₃N₃O₂

CAS number

116776-79-1

IUPAC name

6-chloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole

State

This compound is typically a solid at room temperature. It has well-defined crystalline properties, depending on synthesis and processing methods.

Melting point (Celsius)

202.00

Melting point (Kelvin)

475.15

Boiling point (Celsius)

375.00

Boiling point (Kelvin)

648.15

General information

Molecular weight

282.59g/mol

Molar mass

282.5860g/mol

Density

1.6060g/cm³

Appearence

6-Chloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole typically appears as a solid substance. The color may vary depending on the purity and specific form in which it is obtained.

Comment on solubility

Solubility of 6-chloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 6-chloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole can be characterized as follows:

Solvent Compatibility: The compound exhibits variable solubility in different solvents. It is generally more soluble in organic solvents such as DMSO and DMF, while showing significantly lower solubility in water.
Polarity Influence: The introduction of electronegative elements such as chlorine and nitrogen, along with the trifluoromethyl group, enhances its polarity. This can affect its solubility profile and suggests that it may preferentially dissolve in polar organic solvents.
Temperature Dependence: Like many organic compounds, the solubility may increase with temperature, allowing for better dissolution at elevated temperatures in suitable solvents.

To summarize, while 6-chloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole demonstrates limited aqueous solubility, it can be effectively utilized in polar organic environments due to its structural characteristics.

Interesting facts

Exploring 6-Chloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole

6-Chloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound that showcases the versatility of benzimidazole derivatives. This chemical is part of a larger family known for their diverse biological activities. Here are some intriguing aspects of this compound:

Structural Versatility: The presence of chlorine, nitro, and trifluoromethyl groups contributes to a rich structural profile, enhancing its potential reactivity and interactions.
Biological Relevance: Benzimidazole derivatives are well-known for their pharmacological properties. Some members of this family possess antimicrobial, antifungal, and anti-inflammatory activities, making them valuable in medicinal chemistry.
Research Opportunities: Due to its unique functional groups, 6-chloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole serves as an excellent candidate for the development of new drugs and agrochemicals.
Mechanistic Insights: Understanding how such compounds interact at the molecular level can lead to breakthroughs in targeting specific biological pathways, particularly in cancer research.

In summary, the study of 6-chloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole not only unveils the intricacies of chemical synthesis but also opens doors to new realms in drug discovery and development. As scientists continue to explore this compound, we may unveil even more remarkable properties and applications worth considering in future research.