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Rivaroxaban

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Identification
Molecular formula
C19H18ClN3O5S
CAS number
366789-02-8
IUPAC name
6-chloro-N-(4-guanidinosulfonylphenyl)-4-oxo-chromene-2-carboxamide
State
State

At room temperature, Rivaroxaban is typically found as a solid. This is due to its stable crystalline form under standard conditions.

Melting point (Celsius)
230.00
Melting point (Kelvin)
503.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
435.89g/mol
Molar mass
435.8850g/mol
Density
1.5497g/cm3
Appearence

Rivaroxaban appears as a white to yellowish powder. It is characterized by its crystalline structure, although its color may vary slightly depending on the sample's purity and formulation.

Comment on solubility

Solubility of 6-chloro-N-(4-guanidinosulfonylphenyl)-4-oxo-chromene-2-carboxamide

The solubility of 6-chloro-N-(4-guanidinosulfonylphenyl)-4-oxo-chromene-2-carboxamide in various solvents can offer valuable insights into its potential applications and usability. Understanding the solubility characteristics of this compound involves several factors:

  • Polarity: As a compound containing both sulfonyl and amide groups, it is likely to exhibit polar characteristics. This can enhance its solubility in polar solvents, such as water and methanol.
  • Hydrogen Bonding: The presence of amide functional groups indicates the potential for hydrogen bonding, which can significantly impact its solubility in aqueous solutions. Solubility may increase in the presence of hydrogen bonding solvents.
  • Temperature Dependence: Solubility can be influenced by temperature; typically, an increase in temperature leads to increased solubility for many solid compounds. Hence, experimentation at various temperatures can be insightful.
  • pH Influence: The guanidino group may affect the compound's solubility depending on the pH of the solution, as it can ionize under certain conditions, further influencing solubility in different environments.

In summary, the solubility of 6-chloro-N-(4-guanidinosulfonylphenyl)-4-oxo-chromene-2-carboxamide is governed by a combination of polarity, the ability to form hydrogen bonds, temperature variations, and pH levels. As it stands, precise solubility data must be obtained through experimental analysis to fully understand its behavior in various solvents.

Interesting facts

Interesting Facts about 6-chloro-N-(4-guanidinosulfonylphenyl)-4-oxo-chromene-2-carboxamide

6-chloro-N-(4-guanidinosulfonylphenyl)-4-oxo-chromene-2-carboxamide is a fascinating compound that showcases the intricate world of pharmaceutical chemistry. Here are some intriguing aspects of this compound:

  • Medicinal Potential: This compound has been studied for its potential therapeutic applications, especially in the field of cancer research. Its unique structure allows for interaction with biological targets that may help in the development of novel drugs.
  • Chromene Derivative: As a member of the chromene family, it possesses an aromatic structure that is not only aesthetically pleasing but also crucial for its biological activity. Chromenes are known for their diverse pharmacological properties.
  • Guanidinosulfonamide Moiety: The inclusion of a guanidinosulfonyl group is significant as it enhances the solubility and biological activity of the compound. This functional group is often associated with improved binding to target proteins.
  • Structure-Activity Relationship: Researchers are continuously exploring the structure-activity relationships (SAR) of compounds like this one. Understanding how changes in the molecular structure can affect activity is key to drug design.

As a student of chemistry, one might consider this compound a prime example of how complex molecular structures can lead to interesting biological properties. The synthesis and modification of similar compounds can provide valuable insights into the development of new therapeutic agents.

In summary, 6-chloro-N-(4-guanidinosulfonylphenyl)-4-oxo-chromene-2-carboxamide stands out as an essential compound within medicinal chemistry. Its multifaceted characteristics and significance in drug discovery make it a noteworthy subject for both scholars and researchers.

Synonyms
4H-1-BENZOPYRAN-2-CARBOXANILIDE, 4'-(AMIDINOSULFAMOYL)-6-CHLORO-4-OXO-
27455-35-2
BRN 1409782
4'-(Amidinosulfamoyl)-6-chloro-4-oxo-4H-1-benzopyran-2-carboxanilide
DTXSID70181870
4H-1-Benzopyran-2-carboxamide, N-(4-(((aminoiminomethyl)amino)sulfonyl)phenyl)-6-chloro-4-oxo-