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Chloroquine

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Identification
Molecular formula
C18H26ClN3
CAS number
54-05-7
IUPAC name
6-(diethylcarbamoyl)cyclohex-3-ene-1-carboxylic acid;N-(6-methoxy-4-quinolyl)-N',N'-dimethyl-ethane-1,2-diamine
State
State

At room temperature, chloroquine is in a solid state.

Melting point (Celsius)
87.00
Melting point (Kelvin)
360.15
Boiling point (Celsius)
631.40
Boiling point (Kelvin)
904.60
General information
Molecular weight
319.87g/mol
Molar mass
319.8710g/mol
Density
1.0340g/cm3
Appearence

Chloroquine is typically found in the form of a white to slightly cream-colored crystalline powder. It is usually odorless and has a bitter taste. When sold in pharmacies, it is often presented as a phosphate salt in a tablet form.

Comment on solubility

Solubility of 6-(diethylcarbamoyl)cyclohex-3-ene-1-carboxylic acid; N-(6-methoxy-4-quinolyl)-N',N'-dimethyl-ethane-1,2-diamine

The solubility of chemical compounds is a critical parameter that affects their behavior in various environments. For the compound 6-(diethylcarbamoyl)cyclohex-3-ene-1-carboxylic acid; N-(6-methoxy-4-quinolyl)-N',N'-dimethyl-ethane-1,2-diamine, several factors influence its solubility:

  • Polarity: The presence of polar functional groups, such as carboxylic acid and amines, can significantly enhance water solubility.
  • Hydrophobicity: The cyclohexene structure and aliphatic chains may impart hydrophobic characteristics, potentially reducing solubility in polar solvents.
  • Hydrogen Bonding: Capable of forming hydrogen bonds, this compound may exhibit increased solubility in solvents that can engage in hydrogen bonding.

It is worth noting that the solubility of compounds can be determined by general observations from a category of similar compounds:

  1. Compounds with smaller molecular weights tend to have better solubility.
  2. Structural variations, like substituents and their positions, can yield significant differences in solubility properties.
  3. Interactions with solvent molecules are crucial; similar polarity generally leads to better solubility.

Thus, understanding the solubility of 6-(diethylcarbamoyl)cyclohex-3-ene-1-carboxylic acid; N-(6-methoxy-4-quinolyl)-N',N'-dimethyl-ethane-1,2-diamine requires a comprehensive analysis of its molecular structure and interactions with potential solvents.

Interesting facts

Interesting Facts about 6-(Diethylcarbamoyl)cyclohex-3-ene-1-carboxylic Acid and N-(6-Methoxy-4-quinolyl)-N',N'-Dimethyl-Ethane-1,2-Diamine

This intriguing compound, featuring both a cyclohexene and a quinoline derivative, represents a confluence of various chemical functionalities, making it a subject of interest in medicinal chemistry and drug development. Here are some key facts:

  • Structural Complexity: The compound exhibits a unique structural motif incorporating a cyclohexene ring fused with a carboxylic acid, which enhances its potential reactivity and interaction with biological targets.
  • Biological Relevance: The presence of the quinoline moiety is noteworthy, as quinolines are known for their diverse biological activities, including antibacterial, antimalarial, and antitumor properties.
  • Potential Applications: Due to its dual functionality, this compound may serve as a lead compound in the design of novel pharmaceuticals targeting various diseases or conditions.
  • Substituent Influence: The diethylcarbamoyl group can influence the lipophilicity of the molecule, potentially enhancing its ability to cross biological membranes and increasing its efficacy as a drug.
  • Environmentally Friendly Synthesis: There has been a growing interest in synthesizing compounds like this using greener methods, reducing the environmental impact of chemical productions.

In conclusion, the intricate design of 6-(diethylcarbamoyl)cyclohex-3-ene-1-carboxylic acid along with N-(6-methoxy-4-quinolyl)-N',N'-dimethyl-ethane-1,2-diamine demonstrates how the integration of various chemical elements can lead to promising biological applications. As a student or budding chemist, understanding its structure-function relationship can provide insights into rational drug design and discovery.

Synonyms
QUINETOLATE
Quinetalate
Quinetalatum
5714-76-1
Quinetolate [USAN]
Quinetalate [INN]
56UTZ1RCNO
Chinetalatum
Quinetalato
UNII-56UTZ1RCNO
Quinetalatum [INN-Latin]
Quinetalato [INN-Spanish]
EINECS 227-207-0
Quinetolate (USAN/INN)
6-(Diethylcarbamoyl)-3-cyclohexene-1-carboxylic acid compound with 4-((2-(dimethylamino)ethyl)amino)-6-methoxyquinoline (2:1)
SCHEMBL2111044
DTXSID30972605
IYQFWDZTTDVVBP-UHFFFAOYSA-N
6-Diethylcarbamoyl-3-cyclohexencarbonsaeure Verbindung mit 4-((2-dimethylamino)ethylamino)-6-methoxychinolin 2:1
D05678
Q27261436
6-(Diethylcarbamoyl)cyclohex-3-ene-1-carboxylic acid--2-[(6-methoxyquinolin-4(1H)-ylidene)amino]-N,N-dimethylethan-1-amine (2/1)