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Methadone hydrochloride

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Identification
Molecular formula
C21H28ClNO
CAS number
1095-90-5
IUPAC name
6-(dimethylamino)-4,4-diphenyl-heptan-3-one;hydrochloride
State
State

At room temperature, methadone hydrochloride is typically in the form of a solid due to its crystalline nature. It is stable under normal conditions but should be stored in a well-sealed container to avoid moisture uptake.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.15
Boiling point (Celsius)
170.00
Boiling point (Kelvin)
443.15
General information
Molecular weight
345.89g/mol
Molar mass
345.8890g/mol
Density
1.0143g/cm3
Appearence

Methadone hydrochloride typically appears as a white or off-white crystalline powder. It is known to be hygroscopic, which means it can absorb moisture from the air. The compound is often odorless or may have a very slight odor.

Comment on solubility

Solubility of 6-(dimethylamino)-4,4-diphenyl-heptan-3-one hydrochloride

The solubility of the compound 6-(dimethylamino)-4,4-diphenyl-heptan-3-one hydrochloride can be quite intriguing due to its structural characteristics. Being a hydrochloride salt, it generally exhibits different solubility properties compared to its base form.

Here are some key points regarding its solubility:

  • Aqueous Solubility: As a hydrochloride salt, it is typically more soluble in water compared to non-ionized forms, owing to the presence of the ionic hydrochloride group.
  • Organic Solvents: Solubility in organic solvents may vary, and it might exhibit limited solubility in non-polar solvents due to the bulky diphenyl groups impacting interactions.
  • Temperature Dependency: Like many compounds, the solubility can increase with temperature, which is imperative to consider when preparing solutions.
  • pH Influence: The solubility can also be affected by the pH of the solution; at lower pH values, the ionic form predominates, enhancing its solubility.

In summary, the solubility of 6-(dimethylamino)-4,4-diphenyl-heptan-3-one hydrochloride suggests that it is more soluble in aqueous environments due to its ionic nature, while its behavior in organic solvents may require further investigation. Understanding these solubility properties is crucial for practical applications in various chemical and pharmaceutical contexts.

Interesting facts

Interesting Facts about 6-(dimethylamino)-4,4-diphenyl-heptan-3-one; hydrochloride

This fascinating compound, known as 6-(dimethylamino)-4,4-diphenyl-heptan-3-one; hydrochloride, has gained significant attention in both research and industrial applications. Here are some key points to consider:

  • Pharmaceutical Relevance: This compound is often investigated for its potential use in the pharmaceutical industry, particularly as a building block for developing new medications.
  • Polyfunctional Group: Its structure features a dimethylamino group, which contributes to its unique chemical properties and potential biological activities.
  • Colorimetric Applications: Researchers have explored its use in colorimetric assays, making it valuable in analytical chemistry for detecting various substances.
  • Mechanism of Action: The compound may interact with specific receptors or enzymes, providing insights into its mechanism of action, and thus, informing future chemical designs.
  • Importance of the Hydrochloride Salt: The hydrochloride form enhances the solubility of the compound, facilitating easier handling and incorporation into formulations.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This rings true in the study of compounds like this, as its potential effects and mechanisms open doors for innovative research and applications.

Overall, 6-(dimethylamino)-4,4-diphenyl-heptan-3-one; hydrochloride is a prime example of how organic chemistry blends creativity with scientific inquiry, enabling advancements that can impact various fields from medicine to materials science.

Synonyms
Methadone hydrochloride
Mecodin
Phenadone hydrochloride
Methadone HCL
1095-90-5
Heptadon
Adanon hydrochloride
Dolophine hydrochloride
Westadone
Dolophin hydrochloride
AN-148
Althose
Methadone hydrochloride cii
NSC-19600
Methadone hydrochloride intensol
DTXSID2020501
CHEBI:50140
3-HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, HYDROCHLORIDE
6-(dimethylamino)-4,4-diphenylheptan-3-one hydrochloride
DTXCID80501
NSC19600
229809935B
6-Dimethylamino-4,4-diphenyl-3-heptanone hydrochloride
3-HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, HYDROCHLORIDE (1:1)
METHADONE HYDROCHLORIDE (USP-RS)
METHADONE HYDROCHLORIDE [USP-RS]
METHADONE HYDROCHLORIDE (EP IMPURITY)
METHADONE HYDROCHLORIDE [EP IMPURITY]
METHADONE HYDROCHLORIDE CII (USP-RS)
METHADONE HYDROCHLORIDE CII [USP-RS]
METHADONE HYDROCHLORIDE (EP MONOGRAPH)
METHADONE HYDROCHLORIDE [EP MONOGRAPH]
METHADONE HYDROCHLORIDE (USP MONOGRAPH)
METHADONE HYDROCHLORIDE [USP MONOGRAPH]
Diskets
Methadose Dispersible
Methadone Hydrocloride
Hydrochloride, Methadone
METHADOSESUGAR-FREE
Methadone Hydrocloridedye-free, sugar-free, unflavored
4,4-Diphenyl-6-dimethylamino-heptanone-3 hydrochloride
1,1-Diphenyl-1-(beta-dimethylaminopropyl)butanone-2 hydrochloride
214-140-7
(6rs)-6-(dimethylamino)-4,4-diphenylheptan-3-one monohydrochloride
Algolysin
Butalgin
Fenadone
Depridol
Dolophine
Methadose
Moheptan
Miadone
Dolofin hydrochloride
Ketalgin hydrochloride
Algidon
Fenadon
Polamidon
Adolan
Physeptone
Diaminon hydrochloride
DL-Methadone hydrochloride
Dolohepton
Althose hydrochloride
Mephenon
Racemic methadone hydrochloride
rac Methadone Hydrochloride
(+-)-Methadone hydrochloride
CCRIS 3320
Methadonium chloride
4,4-Diphenyl-6-dimethylamino-3-heptanone hydrochloride
Hoechst 10820
6-(Dimethylamino)-4,4-diphenyl-3-heptanone hydrochloride
dl-6-Dimethylamino-4,4-diphenyl-3-heptanone hydrochloride
AN 148
125-56-4
6-Dimethylamino-4,4-diphenyl-3-heptanone.HCl
d,l-Methadone.HCl
6-(dimethylamino)-4,4-diphenylheptan-3-one;hydrochloride
Tussal
3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (+-)-
Diskets dispersible
(+-)-Tussal
CAS-1095-90-5
rac Methadone Hydrochloride (1mg/mL in Methanol)
EINECS 214-140-7
NSC 19600
Methadose Sugar-Free Oral
Biscuits
Dollies
Macodin
Medicine
Dolly
Methadone hydrochloride [USP]
Tussol:
DRG-0023
Amidone hydrochloride
UNII-229809935B
AZT + Methadone HCl
(+/-)-Tussal
(.+-.) Tussal
Methadone hydrochloride dl-
DL-Methadone, hydrochloride
SCHEMBL24293
Dolophine hydrochloride (TN)
MLS003922099
CHEMBL1200825
(.+-.)-Methadone hydrochloride
Methadone hydrochloride (JAN/USP)
1,1-Diphenyl-1-(2-dimethylaminopropyl)-2-butanone hydrochloride
QCA56672
METHADONE HYDROCHLORIDE [MI]
Tox21_112895
Tox21_202026
Tox21_300633
METHADONE HYDROCHLORIDE [JAN]
FR27536
METHADONE HYDROCHLORIDE [VANDF]
METHADONE HYDROCHLORIDE [WHO-DD]
NCGC00254397-01
NCGC00259575-01
SMR000058978
METHADONE HYDROCHLORIDE [ORANGE BOOK]
NS00076214
D02102
WLN: 2VXR & R & Y2 & N1 & 1
3-Heptanone,4-diphenyl-, hydrochloride,(.+-.)-
3-Heptanone,4-diphenyl-, hydrochloride, (.+-.)-
Q26840915
(+/-)-Methadone hydrochloride, powder, >=98% (TLC)
d,l-Methadone.HCl, 1mg/ml in Methanol (as free base)
(+/-)-Methadone-d3 hydrochloride (3-heptanone-1,1,1-d3)
3-Heptanone, dl-6-dimethylamino-4,4-diphenyl-, hydrochloride
4,4-Diphenyl-6-dimethylamino-3-heptanone hydrochloride (+/-)-
dl-6-(Dimethylamino)-4,4-diphenyl-3-heptanone hydrochloride
4,4-Diphenyl-6-(dimethylamino)-3-heptanone hydrochloride(.+-.)-
6-(Dimethylamino)-4,4-diphenyl-3-heptanone hydrochloride (1:1)
(6RS)-6-(Dimethylamino)-4,4-diphenylheptan-3-one monohydrochloride
3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride (8CI,9CI)
6-(Dimethylamino)-4,4-diphenyl-3-heptanone hydrochloride;(+/-)-Methadone hydrochloride;AN 148