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6-Ethoxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline

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Identification
Molecular formula
C13H19NO2
CAS number
63924-84-5
IUPAC name
6-ethoxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline
State
State

6-Ethoxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline exists as a solid at room temperature, generally in the form of crystalline powder. Its stability as a solid at ambient conditions makes it convenient for handling and storage.

Melting point (Celsius)
78.50
Melting point (Kelvin)
351.65
Boiling point (Celsius)
314.30
Boiling point (Kelvin)
587.45
General information
Molecular weight
221.30g/mol
Molar mass
221.2790g/mol
Density
1.0792g/cm3
Appearence

6-Ethoxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline is typically a white or off-white crystalline solid with a slight aromatic odor. The appearance of such compounds can vary slightly depending on the purity and specific physical form (e.g., powder, crystal), but it is largely consistent within these characteristics.

Comment on solubility

Solubility of 6-ethoxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline

The solubility of 6-ethoxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline can vary significantly depending on the solvent used, as well as temperature and pH. Here are some key points to consider:

  • Polar vs. Nonpolar Solvents: This compound is more likely to be soluble in polar solvents such as water and alcohols due to the presence of ethoxy and methoxy groups which can interact favorably with such solvents.
  • Temperature Effects: The solubility often increases with temperature. Therefore, at elevated temperatures, one might observe a higher solubility of this compound in organic solvents.
  • pH Dependency: The solubility may also be affected by the pH of the solution, as certain functional groups can ionize under different pH conditions, thus enhancing solubility in aqueous environments.

In summary, understanding the solubility of 6-ethoxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline requires consideration of the specific solvent, temperature, and potential interactions influenced by pH. This highlights the complexity of solubility and the importance of conducting empirical tests for accurate characterization.

Interesting facts

Interesting Facts about 6-Ethoxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline

6-Ethoxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline is an intriguing compound with several notable characteristics that make it a subject of interest in both medicinal chemistry and organic synthesis.

Key Features:

  • Structural Diversity: This compound belongs to the tetrahydroisoquinoline family, which is renowned for its diverse range of biological activities. The incorporation of ethoxy and methoxy groups enhances its structural complexity, potentially leading to varied pharmacological effects.
  • Pharmacological Potential: Compounds similar to 6-ethoxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline have been studied for their neuroprotective properties and potential use in treating neurological disorders, such as Parkinson's disease and depression.
  • Natural Occurrence: Some isoquinoline derivatives have been discovered in nature, particularly in plants used in traditional medicine, which could hint at the compound's therapeutic applications.
  • Versatile Intermediates: Due to its unique structure, this compound can serve as an important intermediate in the synthesis of other biologically relevant molecules, showcasing its utility in pharmaceutical chemistry.

Research Insights:

Scientists are keenly interested in studying the structure-activity relationship (SAR) of this compound and its analogs. According to researchers, “The modifications on the tetrahydroisoquinoline framework can significantly influence the binding affinity to various biological targets.”

This highlights the importance of chemical modifications and how they can lead to enhanced activities or side effects, shedding light on the ongoing pursuit of designing more effective medications.

Conclusion:

In summary, 6-ethoxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline is a fascinating compound that encapsulates the intersection of organic chemistry and pharmacology. Its diverse potential applications and the ongoing research surrounding it indicate that there is still much to explore in terms of its effects and uses in medicine.