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Fluticasone propionate

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Identification
Molecular formula
C25H31F3O5
CAS number
80474-14-2
IUPAC name
(6-fluoro-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) propanoate
State
State

At room temperature, Fluticasone propionate is a solid. It is typically found in a powdered form for medicinal use. Its solid state is stable under standard environmental conditions.

Melting point (Celsius)
273.15
Melting point (Kelvin)
546.30
Boiling point (Celsius)
344.15
Boiling point (Kelvin)
617.30
General information
Molecular weight
500.56g/mol
Molar mass
500.5570g/mol
Density
1.2200g/cm3
Appearence

Fluticasone propionate is a white to almost white powder. It has minimal solubility in water, but it is slightly soluble in dimethyl sulfoxide and dimethylformamide. The compound can be recognized by its crystal structure, which contributes to its unique appearance.

Comment on solubility

Solubility of (6-fluoro-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) propanoate

The solubility of (6-fluoro-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) propanoate can be nuanced due to its complex structure and the presence of hydrophobic regions. Here are some key points regarding its solubility:

  • Polar vs. Non-Polar Solvents: Typically, compounds that feature a greater number of hydrophobic groups, like this one, tend to show limited solubility in polar solvents such as water. Instead, they are often more soluble in non-polar organic solvents.
  • Influence of Chemical Groups: The presence of substituents such as the propanoate group may increase the compound’s solubility in non-polar organic solvents, while the fluoro group can introduce polar characteristics.
  • Solubility Patterns: Compounds similar in structure to this one have been observed to demonstrate variable solubility based on factors like temperature and solvent composition.

As a rule of thumb, compounds with complex, large molecular structures often exhibit low solubility in aqueous solutions. It’s essential to consider evaluating solubility in different environments to fully understand its behavior:

  1. Test in solvents like ethanol or chloroform for potentially better solubility.
  2. Utilize mixed solvent approaches to improve overall solubility.

In conclusion, further experimental data would be instrumental in defining the precise solubility profile for this compound, given its intricate configuration.

Interesting facts

Interesting Facts About 6-Fluoro-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl Propanoate

This intriguing compound, with its complex structure, belongs to a class of chemicals that exhibit potent biological activity. Here are some key insights regarding its significance in the scientific community:

  • Biological Relevance: Compounds like this one are often studied for their potential applications in pharmacology. The presence of a fluorine atom may enhance activity, metabolic stability, or selectivity of the compound towards biological targets.
  • Synthetic Complexity: The synthesis of this compound involves sophisticated organic chemistry techniques that may require multiple reaction steps to achieve the desired structure, reflecting the challenging nature of creating complex organic molecules.
  • Structure-Activity Relationship (SAR): The variations in structure, such as substituents at specific positions, can dramatically influence the compound's pharmaceutical properties. Researchers often explore these relationships to optimize efficacy and reduce side effects.
  • Interdisciplinary Research: The study of such compounds often crosses various fields from medicinal chemistry to molecular biology, illustrating the interdisciplinary nature of modern scientific research.
  • Potential Therapeutic Applications: Compounds like this one are frequently investigated as potential treatments for various diseases, including cancer and endocrine disorders, demonstrating their significance in drug discovery.

As the exploration of new compounds continues to evolve, understanding the chemical properties and biological implications of complex molecules such as this one is crucial. The research surrounding them not only expands the compendium of known drugs but also opens doors to innovative therapeutic strategies that can better address pressing health concerns.

Synonyms
PD070938