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6-Fluoro-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C8H4F4N2
CAS number
1026772-05-4
IUPAC name
6-fluoro-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, 6-Fluoro-2-(trifluoromethyl)-1H-benzimidazole is typically found in a solid state.

Melting point (Celsius)
87.00
Melting point (Kelvin)
360.15
Boiling point (Celsius)
214.00
Boiling point (Kelvin)
487.15
General information
Molecular weight
218.13g/mol
Molar mass
218.1330g/mol
Density
1.5450g/cm3
Appearence

6-Fluoro-2-(trifluoromethyl)-1H-benzimidazole is generally a white to off-white solid powder.

Comment on solubility

Solubility of 6-fluoro-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 6-fluoro-2-(trifluoromethyl)-1H-benzimidazole can be characterized by several factors due to its unique structure. This compound exhibits a complex interaction with solvents, influenced by its polar and non-polar functional groups.

Some key points to consider about its solubility include:

  • Polarity: The presence of fluorine atoms significantly affects the polarity of the compound, which increases its interaction with polar solvents.
  • Solvent Compatibility: It is often soluble in dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), both of which are polar aprotic solvents.
  • Hydrophobic Characteristics: The trifluoromethyl group contributes to increased hydrophobic interactions, which may limit solubility in purely aqueous environments.
  • Temperature Dependence: Solubility may also change with temperature, as higher temperatures can enhance solubility for many organic compounds.

In conclusion, while 6-fluoro-2-(trifluoromethyl)-1H-benzimidazole is more soluble in polar aprotic solvents, its solubility in water is relatively low due to its hydrophobic characteristics, making it important to consider the medium when working with this compound.

Interesting facts

Interesting Facts About 6-Fluoro-2-(trifluoromethyl)-1H-benzimidazole

6-Fluoro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound that showcases the intricate relationship between molecular structure and biological activity. Below are some key insights into this compound:

  • Functional Versatility: The presence of both fluorine and trifluoromethyl groups in its structure makes this compound highly versatile in terms of reactivity and interactions with biological systems.
  • Antimicrobial Properties: Compounds containing fluorine are known for their enhanced activity against various pathogens. This molecular design can potentially lead to novel therapeutics in the fight against resistant strains.
  • Pharmaceutical Significance: Many benzimidazole derivatives have been studied for their role in drug discovery, particularly as anti-cancer agents. The unique attributes of this compound make it an interesting candidate for research.
  • Structural Stability: Fluorinated compounds often have increased metabolic stability, which can prolong their effectiveness as pharmaceutical agents. This stability is crucial for the development of long-acting drugs.
  • Research Potential: The synthesis and functionalization of this compound may lead to advancements in materials science, including the creation of potent catalysts or novel agrochemicals.

In the words of renowned chemist Marie Curie, “Nothing in life is to be feared, it is only to be understood.” This compound stands as a testament to the intricate dance between fear and understanding in the realm of chemical research. Continued investigation into its properties and potential applications can yield significant benefits for both science and society.

Overall, the exploration of 6-fluoro-2-(trifluoromethyl)-1H-benzimidazole not only enriches our understanding of chemical interactions but also holds promise for future innovations in various scientific fields.

Synonyms
3671-47-4
BENZIMIDAZOLE, 5-FLUORO-2-(TRIFLUOROMETHYL)-
5-Fluoro-2-(trifluoromethyl)benzimidazole
DTXSID70190169
DTXCID30112660
6-Fluoro-2-(trifluoromethyl)-1H-benzo[d]imidazole
6-fluoro-2-(trifluoromethyl)-1H-benzimidazole
5-Fluoro-2-(trifluoromethyl)-1H-benzo[d]imidazole
5-fluoro-2-(trifluoromethyl)-1H-1,3-benzodiazole
ZZRMDPMUZKDLTO-UHFFFAOYSA-N
ALBB-033321
MFCD01658608
MFCD18070968
AKOS010204458
LS-12617
CS-0078988
5-fluoro-2-(trifluoromethyl)-1H-benzimidazole