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6-Fluorohexanamide

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Identification
Molecular formula
C6H12FNO
CAS number
20334-69-0
IUPAC name
6-fluorohexanamide
State
State

At room temperature, 6-Fluorohexanamide is in a solid state. It remains solid and stable under standard laboratory conditions, making it amenable to various standard chemical applications and storage.

Melting point (Celsius)
77.50
Melting point (Kelvin)
350.50
Boiling point (Celsius)
278.70
Boiling point (Kelvin)
551.80
General information
Molecular weight
133.17g/mol
Molar mass
133.1830g/mol
Density
1.0130g/cm3
Appearence

6-Fluorohexanamide typically appears as a white to off-white solid, which might form as a crystalline powder. Its appearance may vary based on the method of preparation and any impurities present, though it generally maintains a solid state under standard laboratory conditions.

Comment on solubility

Solubility of 6-fluorohexanamide

6-fluorohexanamide, with its distinct structure, presents a unique profile in terms of solubility. This compound exhibits a moderate level of solubility in various solvents due to its polar functional groups and the hydrophobic nature of the hexane chain. Typically, we can categorize its solubility as follows:

  • Solubility in Water: 6-fluorohexanamide has limited solubility in water, primarily attributed to its hydrophobic hexane chain, which inhibits extensive hydrogen bonding with water molecules.
  • Solubility in Organic Solvents: This compound is generally more soluble in organic solvents like ethanol, acetone, and DMSO. The presence of the amide group enhances solvation in polar organic solvents due to dipole interactions.
  • Temperature Effects: As with many amides, an increase in temperature may improve solubility in both water and organic solvents.

In summary, the solubility of 6-fluorohexanamide is influenced by several factors including:

  • The length of the hydrophobic carbon chain
  • The presence of the polar amide functional group
  • Interactions with different solvent types

In conclusion, while water solubility might be somewhat restricted, the compound shows a favorable solubility profile in polar organic solvents, making it versatile for various chemical applications.

Interesting facts

Interesting Facts about 6-Fluorohexanamide

6-Fluorohexanamide is a fascinating organic compound that showcases the intriguing interplay between halogens and amide functionalities in organic chemistry. Here are some compelling details about this compound:

  • Fluorine Influence: The presence of the fluorine atom at the 6-position significantly alters the reactivity and chemical properties of hexanamide. Fluorine is known for its electronegativity, resulting in unique molecular interactions.
  • Synthesis Pathways: 6-Fluorohexanamide can be synthesized via various methods, often utilizing nucleophilic substitution reactions. This highlights the versatility of synthetic strategies in organic chemistry.
  • Pharmaceutical Relevance: Compounds bearing fluorine atoms like 6-fluorohexanamide often exhibit enhanced biological activity, making them integral in the development of pharmaceuticals. Researchers are intrigued by how small changes in structure can lead to significant changes in activity.
  • Environmental Impact: Understanding the behavior of fluorinated compounds in the environment is crucial, as they can persist and bioaccumulate. Studying 6-fluorohexanamide contributes to our knowledge of chemical sustainability.
  • Research Applications: The unique properties of 6-fluorohexanamide make it a subject of study in fields such as materials science, agrochemicals, and medicinal chemistry. Its potential applications are vast, encouraging further exploration.

As a compound that bridges multiple fields of research, 6-fluorohexanamide exemplifies how small molecular adjustments can lead to significant advancements in both scientific understanding and practical applications. Embracing such compounds not only fosters innovation but also deepens our appreciation for the complexity of chemical structures.

Synonyms
6-Fluorohexanoamide
HEXANAMIDE, 6-FLUORO-
675-97-8
BRN 1749731
DTXSID40217852
DTXCID90140343
4-02-00-00932 (beilstein handbook reference)
6-fluorohexanamide
SCHEMBL20520524
AKOS006361058