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6-fluorohexane-1-sulfonyl fluoride

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Identification
Molecular formula
C6H12FO2S
CAS number
756-14-9
IUPAC name
6-fluorohexane-1-sulfonyl fluoride
State
State

6-Fluorohexane-1-sulfonyl fluoride is a liquid at room temperature. The compound's liquid state is stable under normal environmental conditions, making it suitable for various applications and reactions.

Melting point (Celsius)
-10.00
Melting point (Kelvin)
263.15
Boiling point (Celsius)
196.00
Boiling point (Kelvin)
469.15
General information
Molecular weight
200.22g/mol
Molar mass
200.2200g/mol
Density
1.3250g/cm3
Appearence

6-Fluorohexane-1-sulfonyl fluoride is usually a clear and colorless liquid. It can sometimes appear slightly yellow due to impurities. It is typically free from visible particles or cloudiness, maintaining a clear consistency under standard conditions.

Comment on solubility

Solubility of 6-Fluorohexane-1-sulfonyl Fluoride

The solubility of 6-fluorohexane-1-sulfonyl fluoride can be influenced by several factors due to its unique molecular structure. Generally, sulfonyl fluorides are known for their reactivity and polar nature, which significantly affects their interaction with solvents.

  • Water Solubility: This compound is likely to have moderate to low solubility in water. The presence of the sulfonyl group makes it polar; however, the hydrophobic hexane portion may hinder extensive solvation.
  • Solvent Compatibility: It may find better solubility in organic solvents such as:
    • Dichloromethane
    • Acetone
    • Ethyl acetate
  • Temperature Effects: Solubility tends to increase with rising temperature; thus, heating the solvent might enhance the dissolution rate.

In summary, while 6-fluorohexane-1-sulfonyl fluoride demonstrates some polar characteristics lending to potential solubility in specific solvents, its solubility remains a complex topic dependent on the surrounding solvent environment. Always consider performing solubility tests under controlled conditions for precise evaluations.

Interesting facts

Interesting Facts about 6-Fluorohexane-1-sulfonyl Fluoride

6-Fluorohexane-1-sulfonyl fluoride is a remarkable compound in the field of organic chemistry due to its versatile applications and unique properties. Here are some engaging insights:

  • Unique Structure: The presence of the fluorine atom in the hexane chain adds significant polarity to the molecule, enhancing its reactivity. This feature makes it a valuable reagent in synthetic organic chemistry.
  • Reagent Versatility: This compound is often employed as a sulfonylating agent, playing a critical role in the formation of sulfonamides. Its ability to act as a leaving group makes it an essential tool in various chemical syntheses.
  • Pharmaceutical Applications: Due to its reactivity, 6-fluorohexane-1-sulfonyl fluoride can be used in the development of pharmaceuticals, particularly in the synthesis of drug candidates that target specific biological pathways.
  • Environmental Considerations: The introduction of fluorine into chemical structures like this one implies a need for careful consideration of environmental impact, as fluorinated compounds can exhibit persistence in the environment.
  • Reactivity Mechanisms: Understanding the mechanisms by which this compound reacts can shed light on broader principles in organic chemistry, particularly in the context of electrophilic substitutions and nucleophilic attacks.

Quote from a chemist: “The introduction of fluorine into organic molecules often brings about not only increased stability but also enhanced biological activity, paving the way for significant advancements in medicinal chemistry.”

In summary, 6-fluorohexane-1-sulfonyl fluoride exemplifies the fascinating interplay between chemical structure and function, making it a compound worthy of study and exploration in both academic and industrial contexts.

Synonyms
6-Fluorohexanesulphonyl fluoride
372-70-3
HEXANESULFONYL FLUORIDE, 6-FLUORO-
BRN 1766092
DTXSID00190692
6-fluorohexane-1-sulfonyl fluoride
DTXCID40113183