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6-Hydroxy-4-oxo-1H-pyridine-3-carboxylic acid

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Identification
Molecular formula
C6H5NO4
CAS number
490-79-9
IUPAC name
6-hydroxy-4-oxo-1H-pyridine-3-carboxylic acid
State
State

In its pure form at room temperature, it exists as a crystalline solid.

Melting point (Celsius)
324.00
Melting point (Kelvin)
597.20
Boiling point (Celsius)
606.50
Boiling point (Kelvin)
879.70
General information
Molecular weight
167.11g/mol
Molar mass
167.1110g/mol
Density
1.5200g/cm3
Appearence

This compound typically appears as white to off-white crystalline solid.

Comment on solubility

Solubility of 6-hydroxy-4-oxo-1H-pyridine-3-carboxylic acid

The solubility of 6-hydroxy-4-oxo-1H-pyridine-3-carboxylic acid is influenced by several key factors:

  • Polarity: The presence of polar functional groups, such as the hydroxyl (-OH) and carboxylic acid (-COOH) groups, enhances solubility in polar solvents like water.
  • pH Levels: The solubility can vary with changes in pH, especially due to the acidic nature of the carboxylic acid group, which may contribute to better solubility in alkaline solutions.
  • Hydrogen Bonding: This compound can engage in hydrogen bonding with water molecules, further promoting its solubility.
  • Temperature: An increase in temperature can generally enhance solubility, thus application in different temperature ranges can affect the compound's behavior.

In summary, 6-hydroxy-4-oxo-1H-pyridine-3-carboxylic acid exhibits solubility characteristics that are significantly dependent on its chemical structure and the environmental conditions. As a result, it can have relatively good solubility in aqueous solutions, particularly under conditions that promote ionization and hydrogen bonding.

Interesting facts

Interesting Facts about 6-Hydroxy-4-Oxo-1H-Pyridine-3-Carboxylic Acid

6-Hydroxy-4-oxo-1H-pyridine-3-carboxylic acid, also known as quinolinic acid, is a fascinating compound that plays significant roles in biochemical processes. Here are some compelling details about this compound:

  • Biological Significance: This compound is part of the kynurenine pathway, which is crucial for the metabolism of the amino acid tryptophan. It contributes to the synthesis of nicotinamide adenine dinucleotide (NAD+), an essential coenzyme found in all living cells.
  • Neurochemistry: 6-Hydroxy-4-oxo-1H-pyridine-3-carboxylic acid is notable for its dual role as both a neurotoxic agent and a neuroprotective compound. It can induce excitotoxicity through the overactivation of NMDA receptors, potentially linking it to neurodegenerative diseases.
  • Research Applications: This compound is valuable in neurobiology research, allowing scientists to explore its effects in various models of brain injury and psychiatric disorders.
  • Therapeutic Potential: Due to its involvement in neurological pathways, there is ongoing research into its potential therapeutic uses, especially in conditions like schizophrenia and mood disorders.
  • Natural Occurrence: Quinolinic acid can be found naturally in the body as well as in a variety of foods, particularly in grains and meat.

In conclusion, 6-hydroxy-4-oxo-1H-pyridine-3-carboxylic acid is more than just a chemical compound; it has significant implications in health and disease, making it a subject of ongoing scientific inquiry. As stated by researchers, “Understanding the complexities of this compound may unlock vital insights into mental health and neuroprotection.”