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Thioflavin T

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Identification
Molecular formula
C17H19CIN2OS
CAS number
2390-54-7
IUPAC name
6-methoxy-2-[5-(6-methoxy-3-methyl-1,3-benzothiazol-3-ium-2-yl)penta-2,4-dienylidene]-3-methyl-1,3-benzothiazole;iodide
State
State

At room temperature, thioflavin T is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.20
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
318.84g/mol
Molar mass
318.8430g/mol
Density
1.0900g/cm3
Appearence

Thioflavin T is a bright yellow compound that usually appears as a crystalline powder. The powder can fluoresce strongly when it binds to specific substances, such as amyloid fibrils, emitting a characteristic bright yellow fluorescence under ultraviolet light.

Comment on solubility

Solubility of 6-methoxy-2-[5-(6-methoxy-3-methyl-1,3-benzothiazol-3-ium-2-yl)penta-2,4-dienylidene]-3-methyl-1,3-benzothiazole;iodide

Understanding the solubility of this complex compound, 6-methoxy-2-[5-(6-methoxy-3-methyl-1,3-benzothiazol-3-ium-2-yl)penta-2,4-dienylidene]-3-methyl-1,3-benzothiazole;iodide, is crucial for its potential applications in various fields, especially in medicinal chemistry and material science.

When analyzing solubility, consider the following factors:

  • Molecular structure: The presence of multiple functional groups, including methoxy groups and an iodide moiety, typically influences solubility in polar solvents.
  • Polarity: The duality of hydrophobic benzothiazole rings and hydrophilic substituents can lead to variable solubility profiles in different environments.
  • Potential solvents: Common solvents to consider include:
    • Water
    • Ethanol
    • Dimethyl sulfoxide (DMSO)
    • Chloroform

Generally, the presence of the iodide suggests a degree of ionic nature, which may enhance solubility in polar solvents. However, the overall solubility is likely to be influenced by the intricate balance of hydrophilic and hydrophobic interactions within this molecule.

As a guiding principle, it is often said that “like dissolves like.” Therefore, predict the solubility of this compound based on its structural features and the solvent's properties:

  • High solubility: anticipated in polar solvents.
  • Limited solubility: likely in non-polar solvents due to the significant hydrophobic character of the benzothiazole components.

Experimental validation is essential to define the solubility ranges accurately and ensure that the compound can be utilized effectively in practical applications.

Interesting facts

Interesting Facts about 6-Methoxy-2-[5-(6-methoxy-3-methyl-1,3-benzothiazol-3-ium-2-yl)penta-2,4-dienylidene]-3-methyl-1,3-benzothiazole; iodide

The compound, 6-methoxy-2-[5-(6-methoxy-3-methyl-1,3-benzothiazol-3-ium-2-yl)penta-2,4-dienylidene]-3-methyl-1,3-benzothiazole; iodide, showcases a fascinating blend of properties due to its intricate structure and unique composition. Here are some compelling points worth noting:

  • Structural Complexity: This compound contains multiple functional groups and heterocyclic structures, characteristic of benzothiazoles. The presence of the methoxy and methyl groups contributes to its varied chemical reactivity.
  • Biological Relevance: Compounds of this nature are often investigated for their biological activities, notably in medicinal chemistry. The inclusion of the benzothiazole moiety has been linked to potential antimicrobial and anticancer properties.
  • Colorimetric Properties: Benzothiazole derivatives frequently exhibit interesting color changes in solution, which makes them suitable for dye applications or as indicators in various chemical reactions.
  • Ionic Interaction: The iodide in this compound plays a crucial role in its ionic characteristics, affecting both solubility and biological interactions, enhancing its potential for use in therapeutic applications.
  • Research Implications: Its unique chemical structure presents intriguing possibilities for future research, including photochemical studies and the development of novel materials used in organic electronics.

In summary, the diverse applications and biological significance of 6-methoxy-2-[5-(6-methoxy-3-methyl-1,3-benzothiazol-3-ium-2-yl)penta-2,4-dienylidene]-3-methyl-1,3-benzothiazole; iodide render it a valuable compound in the field of chemistry. As noted by many researchers in their studies, such compounds not only broaden our understanding of organic synthesis but also offer avenues for innovation in medicinal and industrial chemistry.

Synonyms
6-Methoxy-2-[5-(6-methoxy-3-methyl-1,3-benzothiazol-2(3H)-ylidene)penta-1,3-dien-1-yl]-3-methyl-1,3-benzothiazol-3-ium iodide
DTXSID50938703