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6-Methoxy-2-nitro-1H-benzimidazole

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Identification
Molecular formula
C8H7N3O3
CAS number
6636-52-6
IUPAC name
6-methoxy-2-nitro-1H-benzimidazole
State
State

At room temperature, 6-Methoxy-2-nitro-1H-benzimidazole is in a solid state.

Melting point (Celsius)
201.00
Melting point (Kelvin)
474.15
Boiling point (Celsius)
425.00
Boiling point (Kelvin)
698.15
General information
Molecular weight
193.16g/mol
Molar mass
193.1550g/mol
Density
1.4410g/cm3
Appearence

6-Methoxy-2-nitro-1H-benzimidazole typically appears as a yellow crystalline solid.

Comment on solubility

Solubility of 6-methoxy-2-nitro-1H-benzimidazole

6-methoxy-2-nitro-1H-benzimidazole (C8H7N3O3) presents an interesting profile in terms of solubility. Its solubility can be influenced by several factors, including:

  • Polarity: The presence of polar nitro and methoxy groups enhances its interaction with polar solvents.
  • Hydrogen bonding: The structure can participate in hydrogen bonding, particularly with water molecules, which may increase its solubility in certain conditions.
  • Temperature: As with many organic compounds, increased temperature often leads to improved solubility.

In general, 6-methoxy-2-nitro-1H-benzimidazole tends to be more soluble in organic solvents such as:

  • Ethanol
  • Dimethyl sulfoxide (DMSO)
  • Methanol

However, it is less soluble in water, which could be attributed to its relatively hydrophobic aromatic system combined with the presence of nitro and methoxy functionalities that may not sufficiently enhance solubility in a predominantly polar solvent like water. In cases where solubility is needed for applications, creating formulations or using co-solvents might prove effective techniques.

Understanding the solubility of this compound is vital for its practical use in various applications, whether in pharmaceuticals or analytical chemistry.

Interesting facts

Interesting Facts about 6-Methoxy-2-nitro-1H-benzimidazole

6-Methoxy-2-nitro-1H-benzimidazole is a fascinating compound that attracts the attention of scientists due to its unique structural characteristics and potential applications in various fields. Here are some engaging insights about this compound:

  • Pharmacological Potential: This compound is part of the benzimidazole family, known for its medicinal properties. Researchers are exploring its efficacy in treating a range of conditions, including cancer and parasitic infections.
  • Synthetic Versatility: The presence of both a methoxy group and a nitro group in its structure opens avenues for further chemical modifications, allowing for the synthesis of derivatives that may display enhanced activity.
  • Research Applications: Due to its heterocyclic nature, 6-methoxy-2-nitro-1H-benzimidazole has been studied in the context of organic electronics, particularly in the development of organic semiconductors.
  • Mechanistic Studies: This compound also serves as a valuable tool in understanding the mechanisms of action of nitrogen-containing heterocycles, contributing significantly to both organic and medicinal chemistry.

In summary, 6-methoxy-2-nitro-1H-benzimidazole encapsulates a world of scientific inquiry and potential, establishing a bridge between fundamental research and practical applications. As stated by leading chemists, “The power of small molecules like this lies in their ability to unlock new therapeutic avenues.”

It is a compelling representation of how small structural variations can lead to significant changes in properties and applications, making it an exciting topic of study for chemists and researchers alike.

Synonyms
10045-42-8
BENZIMIDAZOLE, 5-METHOXY-2-NITRO-
5-Methoxy-2-nitrobenzimidazole
BRN 0789222
DTXSID10143295
DTXCID9065786
6-methoxy-2-nitro-1H-benzimidazole
Benzimidazole,5-Methoxy-2-Nitro-(8Ci)
AKOS006280124
DB-274290