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6-Methoxy-2H-chromene

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Identification
Molecular formula
C10H10O2
CAS number
1726-52-9
IUPAC name
6-methoxy-2H-chromene
State
State

At room temperature, 6-Methoxy-2H-chromene is generally found in a solid state. It can be easily crystallized and is manipulated usually as a crystalline powder in laboratory environments.

Melting point (Celsius)
48.00
Melting point (Kelvin)
321.15
Boiling point (Celsius)
282.00
Boiling point (Kelvin)
555.15
General information
Molecular weight
176.19g/mol
Molar mass
176.1930g/mol
Density
1.1319g/cm3
Appearence

6-Methoxy-2H-chromene typically appears as a colorless to pale yellow crystalline solid. The compound may exhibit a subtle aromatic odor, characteristic of methoxy group-containing chromenes.

Comment on solubility

Solubility of 6-methoxy-2H-chromene

6-methoxy-2H-chromene, a compound with intriguing structural characteristics, exhibits *moderate solubility* in various solvents. Its solubility can be influenced by several factors:

  • Polarity of Solvent: This compound is generally soluble in polar organic solvents such as ethanol and methanol.
  • Non-Polar Solvents: Conversely, it shows limited solubility in non-polar solvents like hexane, due to its polar functional groups.
  • Temperature Dependence: The solubility increases with temperature, making it easier to dissolve in warmer conditions.

In summary, while 6-methoxy-2H-chromene is not highly soluble in water, it finds a favorable environment in organic solvents, affirming the general rule that:

"Like dissolves like."

This principle indicates that the solubility of 6-methoxy-2H-chromene is enhanced in solvents that possess similar polarity to its own chemical structure. Understanding these solubility characteristics can be crucial for its applications in various chemical reactions and formulations.

Interesting facts

Exploring 6-Methoxy-2H-Chromene

The compound 6-methoxy-2H-chromene is a fascinating member of the chromene family, which consists of a broad class of organic compounds featuring a benzopyran structure. With its unique configuration, this compound presents a variety of interesting aspects worth noting:

Chemical and Biological Significance

  • Natural Occurrence: Many chromenes are found in nature, often as secondary metabolites in plants. They contribute to the color of flowers and can have biological activities.
  • Pharmacological Potential: Compounds in this class, including 6-methoxy-2H-chromene, have been studied for their potential anti-inflammatory, antioxidant, and anticancer properties. This opens up avenues for therapeutic applications.
  • Research Applications: The structure of 6-methoxy-2H-chromene makes it a valuable compound for synthesizing derivatives that may enhance its biological activity.

Chemical Properties

  • Resonance Structures: The chromene structure allows for various resonance forms, contributing to its stability and reactivity in chemical reactions.
  • Substituent Effects: The presence of the methoxy group at the 6-position can significantly influence the compound’s chemical behavior and reactivity, a valuable aspect for synthetic chemists.

Fun Facts

  • Some studies suggest that 6-methoxy-2H-chromene may interact with various enzymes, making it a compound of interest in enzymology.
  • This chromene derivative could also serve as a scaffold in drug design, possibly leading to the development of novel pharmaceuticals.

As an essential part of organic chemistry and medicinal research, 6-methoxy-2H-chromene serves as an excellent example of how structural variations can lead to diverse properties and applications. Understanding compounds like this not only enhances our knowledge of chemistry but also demonstrates the intricate relationships between molecular structure and biological activity.

Synonyms
6-methoxy-2H-chromene
18385-84-7
2H-1-BENZOPYRAN, 6-METHOXY-
6-Methoxy-2H-1-benzopyran
6-Methoxy-alpha-chromene
BRN 1282135
5-17-04-00216 (Beilstein Handbook Reference)
6-methoxy-2H-[1]benzopyran
SCHEMBL314910
SCHEMBL5229806
SCHEMBL30545230
DTXSID80171489
LMCDFCKWRNBXBB-UHFFFAOYSA-N
MFCD01662550
SY402303