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Mefloquine

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Identification
Molecular formula
C17H16F6N2O
CAS number
53230-10-7
IUPAC name
(6-methoxy-4-quinolyl)-[(2S,4R)-5-vinylquinuclidin-2-yl]methanol
State
State

At room temperature, Mefloquine is typically in the form of a solid, usually prepared as tablets.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.15
Boiling point (Celsius)
460.00
Boiling point (Kelvin)
733.15
General information
Molecular weight
378.88g/mol
Molar mass
378.8840g/mol
Density
1.3340g/cm3
Appearence

Mefloquine hydrochloride appears as a white or off-white solid, usually in the form of tablets for pharmaceutical formulations. The compound itself is characterized by its crystalline structure.

Comment on solubility

Solubility of (6-methoxy-4-quinolyl)-[(2S,4R)-5-vinylquinuclidin-2-yl]methanol

The solubility of (6-methoxy-4-quinolyl)-[(2S,4R)-5-vinylquinuclidin-2-yl]methanol can be influenced by several factors, including temperature, pH, and the solvent used. Understanding its solubility behavior is essential for various applications in pharmaceutical and chemical research.

Key Factors Affecting Solubility:

  • Polarity of the Solvent: Organic solvents may enhance the solubility of this compound due to its structural characteristics.
  • Temperature: Generally, an increase in temperature can lead to higher solubility.
  • pH Levels: The protonation state of the quinuclidine ring can affect the solubility; thus, it may be pH-dependent.

In terms of specific solubility, studies suggest that compounds similar in structure generally exhibit varied solubility profiles:

  • Highly polar compounds tend to dissolve well in polar solvents.
  • Nonpolar compounds typically show better solubility in nonpolar solvents.

As a general insight, it can be said that:

“The greater the structural similarity to known soluble compounds, the higher the likelihood of solubility.”

In conclusion, further experimental analysis is essential to accurately determine the solubility of (6-methoxy-4-quinolyl)-[(2S,4R)-5-vinylquinuclidin-2-yl]methanol in various solvents and under different conditions to fully understand its utility in practical applications.

Interesting facts

Interesting Facts about (6-methoxy-4-quinolyl)-[(2S,4R)-5-vinylquinuclidin-2-yl]methanol

(6-methoxy-4-quinolyl)-[(2S,4R)-5-vinylquinuclidin-2-yl]methanol is an intriguing compound that showcases the unique blend of quinoline and quinuclidine structures, which has significant implications in medicinal chemistry.

Key Features

  • Hybrid Structure: The combination of the quinoline and quinuclidine moieties results in a compound with diverse chemical properties and potential biological activities.
  • Pharmacological Potential: Compounds with such structures have shown promise in various therapeutic areas, particularly in treating neurodegenerative diseases and as potential antipsychotic agents.
  • Research Significance: The unique stereochemistry involved, particularly the (2S,4R) configuration, highlights the importance of stereoisomerism in influencing the pharmacodynamics of the compound.

Moreover, the presence of the methoxy group in the quinoline ring could enhance the lipophilicity of the molecule, potentially facilitating its passage through biological membranes, making it more effective as a drug candidate.

Scientific Insights

As a scientist studying this compound, one might ponder:

  • What specific mechanisms of action does this compound exhibit in neuronal pathways?
  • Could the compound serve as a scaffold for the development of more selective and effective derivatives?
  • How do structural modifications influence its binding affinity to target receptors?

This compound is not only a testimony to the creative potential of chemical synthesis but also illuminates pathways for novel drug discovery. With ongoing research, the future of compounds like this one remains promising and warrants further investigation.