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Quinine hydrochloride

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Identification
Molecular formula
C20H25ClN2O2
CAS number
130-89-2
IUPAC name
(6-methoxy-4-quinolyl)-(4-vinylquinuclidin-2-yl)methanol;hydrochloride
State
State

At room temperature, quinine hydrochloride is typically a solid. It is usually found in its anhydrous or dihydrate form.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
312.80
Boiling point (Kelvin)
585.95
General information
Molecular weight
396.91g/mol
Molar mass
396.9110g/mol
Density
1.2000g/cm3
Appearence

Quinine hydrochloride typically appears as a white, crystalline powder. It is often used in pharmaceutical formulations. The crystals are generally very fine and can dissolve readily in water, giving a clear solution.

Comment on solubility

Solubility of (6-methoxy-4-quinolyl)-(4-vinylquinuclidin-2-yl)methanol;hydrochloride

The solubility of the compound (6-methoxy-4-quinolyl)-(4-vinylquinuclidin-2-yl)methanol; hydrochloride can be influenced by various factors due to its complex structure. Here are some key points regarding its solubility characteristics:

  • Hydrochloride Form: The presence of the hydrochloride indicates that the compound is likely to be more soluble in water compared to its free base form, as hydrochloride salts are generally more soluble in polar solvents.
  • Polar and Non-Polar Characteristics: The presence of both methoxy and vinyl groups introduces contrasting polar and non-polar characteristics which can affect solubility. While methoxy contributes to polarity, the vinyl group may create hydrophobic interactions.
  • pH Dependence: The solubility of this compound can vary significantly with changes in pH. It may show increased solubility in acidic conditions due to protonation of the nitrogen atoms in the quinuclidin moiety.
  • Saturation Limits: Careful attention must be paid to saturation limits in solvent systems; exceeding these limits can lead to precipitation.
  • Crystal Lattice Energy: The crystalline structure of the hydrochloride form can impact solubility, as lower lattice energy typically aids in dissolving the compound in a solvent.

In summary, the solubility of (6-methoxy-4-quinolyl)-(4-vinylquinuclidin-2-yl)methanol; hydrochloride is a multifaceted attribute shaped by its molecular configuration and environmental conditions. As a result, understanding its solubility profile is crucial for practical applications in pharmaceuticals and other industrial uses.

Interesting facts

Interesting Facts about (6-methoxy-4-quinolyl)-(4-vinylquinuclidin-2-yl)methanol; hydrochloride

This compound is an intriguing member of the quinoline family, exhibiting both potential therapeutic applications and a unique structural framework. Here are some key points worth noting:

  • Complex Structure: The presence of a quinuclidine moiety alongside the quinoline ring enhances the compound's structural complexity, making it an interesting subject for further research.
  • Potential Pharmacological Activities: Compounds with similar structures have been found to exhibit various pharmacological activities, including antibacterial and antitumor properties. Researchers are particularly interested in exploring how this compound might influence biological systems.
  • Heterocycles: The compound contains nitrogen-rich heterocyclic structures. These types of compounds often play critical roles in drug design due to their ability to interact with biological targets.
  • Research Significance: With ongoing studies in medicinal chemistry, compounds like this one can inspire novel drug development approaches and broaden the understanding of medicinal properties among quinoline derivatives.
  • Versatile Functionalization: The presence of the vinyl group provides an opportunity for further chemical modifications, enabling chemists to tailor the compound for specific applications or improve its efficacy.

In conclusion, (6-methoxy-4-quinolyl)-(4-vinylquinuclidin-2-yl)methanol; hydrochloride serves as an excellent example of how complex organic compounds can open new avenues in medicinal chemistry. As scientists continue to investigate its properties, there is much to look forward to in terms of potential therapeutic benefits and novel applications.

Synonyms
GNF-Pf-5561
MMV665782
CHEMBL580353