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Halofantrine

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Identification
Molecular formula
C26H30ClF3N2O
CAS number
69756-53-2
IUPAC name
(6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanone
State
State

At room temperature, halofantrine is typically a solid, often found in powder form. Given its pharmaceutical application, it is provided as tablets or other dosage forms upon processing.

Melting point (Celsius)
47.00
Melting point (Kelvin)
320.15
Boiling point (Celsius)
593.30
Boiling point (Kelvin)
866.45
General information
Molecular weight
503.63g/mol
Molar mass
503.6320g/mol
Density
1.2540g/cm3
Appearence

Halofantrine appears as a white crystalline solid, which is typically available in powdered form for pharmaceutical use. It is often used in its hydrochloride salt form due to better solubility characteristics.

Comment on solubility

Solubility of (6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanone

The solubility of (6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanone is a noteworthy aspect to consider in both practical applications and theoretical studies. This compound presents a unique structure, which can influence its solubility behavior in various solvents.

Factors Influencing Solubility:

  • Polarity: The presence of the methoxy group may enhance solubility in polar solvents such as water and alcohols.
  • Hydrophobic Interactions: The vinyl and quinoline moieties are generally hydrophobic, creating a challenge in solubilizing the compound in water.
  • pH Sensitivity: The solubility can vary significantly with changes in pH, affecting the ionization of functional groups if present.

As a *general rule*, complexes that form strong interactions with solvents tend to have higher solubility. Thus, depending on the solvent's characteristics, the following may be observed:

  • High Solubility: In organic solvents like ethanol or DMSO.
  • Low Solubility: In non-polar solvents like hexane or cyclohexane.

In conclusion, understanding the solubility profile of (6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanone is crucial for anticipating its behavior in both synthesis and applications. As always, empirical tests remain the best approach to accurately gauge solubility in specific conditions.

Interesting facts

Interesting Facts about (6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanone

(6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanone is a fascinating compound that captures the interest of chemical scientists and students alike. Its unique structure is comprised of two distinct functional groups which provide a rich field for exploration in medicinal chemistry and pharmacology.

Chemical Structure and Properties

The molecular architecture includes:

  • Quinoline moiety: Known for its characteristic aromatic properties, quinoline derivatives have been studied for their biological activities, particularly as antimicrobial and anti-inflammatory agents.
  • Quinuclidine component: This portion is recognized for its versatility in structure-activity relationships and is frequently associated with pharmacologically active compounds, especially in the realm of neurology.

Biological Significance

This compound's potential goes beyond mere theoretical interest:

  • It is being investigated for possible applications in treating various neurological disorders.
  • The dual presence of methoxy and vinyl groups may enhance its ability to interact with biological targets, leading to improved therapeutic outcomes.

Applications in Research

In addition to its medicinal potential, this compound serves as a valuable tool in:

  • Studying neurotransmission: The quinuclidine component is structurally related to certain neurotransmitter systems, making it a candidate for future neuropharmacological studies.
  • Drug discovery: Its unique combination of functional groups can inspire synthetic chemists to create new derivatives with potentially enhanced efficacy.

Ultimately, (6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanone exemplifies the intersection of structure and function in chemistry, serving as a reminder of the intricate connections that can lead to innovative therapeutic solutions. As with many compounds, ongoing research may reveal even more about its properties and possibilities.

Synonyms
569329-55-1
6'-Methoxycinchonan-9-one
CHEMBL15477
(6-Methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methanone
NSC15307
(6-Methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanone
4-{5-ethenyl-1-azabicyclo[2.2.2]octane-2-carbonyl}-6-methoxyquinoline
DTXSID40274485
Maybridge1_006500
(5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanone
6a(2)-Methoxy-9-rubanone
6'-Methoxycinchonan-9-one #
SCHEMBL2894269
HMS559P10
AAA08431
BDBM50047017
NSC101537
NSC-101537
6-methoxy-4-quinolyl-5-vinyl-1-azabicyclo[2.2.2]oct-2-ylmethanone
(6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanone
[(4S,5R,7R)-5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanone