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6-Methoxyquinoline

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Identification
Molecular formula
C10H9NO
CAS number
5263-87-6
IUPAC name
6-methoxyquinoline
State
State

6-Methoxyquinoline is typically found in solid state at room temperature. It is often used in various applications in the form of a crystalline powder.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.15
Boiling point (Celsius)
274.00
Boiling point (Kelvin)
547.15
General information
Molecular weight
159.18g/mol
Molar mass
159.1830g/mol
Density
1.1280g/cm3
Appearence

6-Methoxyquinoline is a pale yellow crystalline solid. It can appear as needle-like crystals or a powder depending on the form in which it is processed or synthesized.

Comment on solubility

Solubility of 6-methoxyquinoline

6-methoxyquinoline is a member of the quinoline family, which is known for its variety of applications, particularly in pharmaceuticals and organic synthesis. Its solubility can be characterized as follows:

  • Solvent Compatibility: 6-methoxyquinoline is generally soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO).
  • Water Solubility: The solubility in water is relatively low due to its hydrophobic aromatic structure which limits its interaction with polar solvent molecules.
  • Temperature Effect: As with many organic compounds, an increase in temperature can enhance the solubility of 6-methoxyquinoline in various solvents, making it more effective for reactions and formulations.

In practical applications, the level of solubility of 6-methoxyquinoline plays a crucial role. *For example:* its solubility profile can influence:

  1. The bioavailability of drugs derived from or utilizing this compound.
  2. The efficiency of extraction and purification processes during synthesis.
  3. The effectiveness of 6-methoxyquinoline in various reaction conditions and reagent formulations.

Overall, understanding the solubility of 6-methoxyquinoline is vital for researchers and practitioners working with this intriguing compound.

Interesting facts

Interesting Facts about 6-Methoxyquinoline

6-Methoxyquinoline is an intriguing compound that plays a significant role in various chemical and pharmaceutical applications. Here are some fascinating highlights:

  • Structural Significance: The presence of the methoxy group at the 6-position of the quinoline structure significantly influences its chemical reactivity and biological activity, making it a subject of extensive research.
  • Biological Activity: Research has demonstrated that 6-methoxyquinoline exhibits considerable antimicrobial and antioxidant properties, making it promising in the development of new therapeutic agents.
  • Utility in Synthesis: This compound is often used as a building block in organic synthesis. It can serve as a precursor for producing other complex organic molecules, especially in medicinal chemistry.
  • Research Applications: Due to its ability to interact with certain biological targets, it has been studied for potential applications in treating diseases such as cancer and infections.
  • Fluorescent Properties: 6-Methoxyquinoline has been noted for its fluorescence characteristics, which can be exploited in various analytical techniques, including spectrophotometry.
  • Historical Context: Quinoline derivatives, including 6-methoxyquinoline, have a long history in medicinal chemistry, with their exploration dating back to the early 19th century. They were initially highlighted for their antimalarial properties.

In summary, 6-methoxyquinoline is not just another compound; it embodies a wealth of possibilities in modern chemical research. Its unique properties and applications continue to inspire scientists and researchers alike, positioning it as a focal point in ongoing studies of organic compounds.

Synonyms
6-Methoxyquinoline
Quinoline, 6-methoxy-
p-Quinanisole
Methyl 6-quinolyl ether
NSC 1954
UNII-5S1U3125AD
CHEBI:72822
5S1U3125AD
NSC-1954
EINECS 226-077-2
AI3-16316
DTXSID9063746
FEMA NO. 4640
Quinoline, 6methoxy
Methyl 6quinolyl ether
DTXCID0041224
hfdldpjyciexjp-uhfffaoysa-n
inchi=1/c10h9no/c1-12-9-4-5-10-8(7-9)3-2-6-11-10/h2-7h,1h
5263-87-6
6-Methoxy-quinoline
MFCD00006800
CHEMBL15200
6-methoxyquinolin
6-methoxy quinoline
6-Methoxyquinoline, 98%
SCHEMBL219324
WLN: T66 BNJ HO1
SCHEMBL12015264
NSC1954
STR09836
BBL027610
BDBM50047014
STL352112
AKOS000121104
CS-W017948
FM25354
FS-3598
HY-W017232
SB67501
AC-18179
AC-37038
SY012831
DB-029317
M0891
NS00014569
EN300-23867
H10211
Q27140168
Z166628264