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6-Methylpiperidin-2-one

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Identification
Molecular formula
C6H11NO
CAS number
1445-73-4
IUPAC name
6-methylpiperidin-2-one
State
State

At room temperature, 6-Methylpiperidin-2-one exists as a liquid. It is stable under standard conditions but may polymerize or degrade at elevated temperatures or in presence of light.

Melting point (Celsius)
-8.00
Melting point (Kelvin)
265.15
Boiling point (Celsius)
219.00
Boiling point (Kelvin)
492.15
General information
Molecular weight
113.17g/mol
Molar mass
113.1690g/mol
Density
1.0115g/cm3
Appearence

6-Methylpiperidin-2-one is a colorless to pale yellow liquid with a slightly pungent odor. It is a cyclic amide and is commonly utilized in organic synthesis and various chemical reactions.

Comment on solubility

Solubility of 6-methylpiperidin-2-one

6-methylpiperidin-2-one, a cyclic compound, exhibits interesting solubility characteristics that make it noteworthy in various applications. Here are some key points regarding its solubility:

  • Polarity: The presence of the carbonyl group and nitrogen in its structure influences the compound's overall polarity, leading to varied solubility behavior.
  • Solvents: 6-methylpiperidin-2-one is generally soluble in polar organic solvents such as ethanol and methanol, due to its ability to engage in hydrogen bonding.
  • Water Solubility: Limited solubility in water can be expected primarily due to its non-polar characteristics dominating its molecular structure.
  • Temperature Influence: Increased temperatures may enhance the solubility of this compound in organic solvents, allowing for greater interaction.

In summary, while 6-methylpiperidin-2-one shows a good affinity for polar solvents, its solubility in water remains restricted. This distinct solubility profile can be a critical factor in its practical applications in chemical synthesis and drug development.

Interesting facts

Interesting Facts about 6-Methylpiperidin-2-one

6-Methylpiperidin-2-one is a fascinating compound that belongs to the piperidine family and has garnered significant interest in the fields of medicinal chemistry and organic synthesis.

Key Characteristics

  • Structural Diversity: The piperidine ring provides a versatile framework that can be modified to create a variety of derivatives with distinct biological activities.
  • Pharmaceutical Potential: This compound serves as an important intermediate in the synthesis of various pharmaceuticals, including neurotransmitter receptor antagonists and analgesics.
  • Natural Occurrences: Compounds with piperidine structures can often be found in nature, contributing to the complexity of many alkaloids.

Applications of 6-Methylpiperidin-2-one

This molecule has multiple applications in different scientific realms:

  • Synthesis of Bioactive Molecules: Researchers utilize 6-methylpiperidin-2-one for crafting complex organic molecules that exhibit antibacterial, antifungal, and anticancer properties.
  • Drug Development: Its derivatives are being explored for the treatment of neurological disorders and other chronic conditions.

Fun Fact

One of the most interesting aspects of 6-methylpiperidin-2-one is its role as a chiral building block. The introduction of chirality can significantly influence the pharmacological properties of the final compound, making it an exciting focus of study for chemists.

In summary, the study of 6-methylpiperidin-2-one and its derivatives not only enhances our understanding of chemical structures and biological interactions but also plays a vital role in the ongoing quest for new therapeutic agents in modern medicine. Its versatility and significance in synthetic chemistry continue to inspire chemists and pharmacologists alike.

Synonyms
6-Methylpiperidin-2-one
6-Methyl-2-piperidone
225-321-5
4775-98-8
2-Piperidinone, 6-methyl-
Methylpentanone isoxime
Methylpentanonisoxim
2-PIPERIDONE, 6-METHYL-
(6R)-6-methyl-2-Piperidinone
6-Methyl-2-piperidinone
MFCD00127922
Methylpentanonisoxim [German]
EINECS 225-321-5
5-Caprolactam
6-Methyl-2-piperidinone; 2-Pipecolin-6-one; Lactam-5-aminohexanoic Acid
2-Pipecolin-6-one
6-methyl-2-piperidon
6-Methyl-2-piperidinone #
SCHEMBL1115431
DTXSID80963927
Hexanoic acid, 5-amino-, lactam
ALBB-028844
AKOS006275727
SB41421
SB47080
AS-50393
SY033090
6-Methyl-3,4,5,6-tetrahydropyridin-2-ol
DB-070851
CS-0009358
NS00046569
EN300-116261
P10077
A827334
Z1198150789