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Isosorbide dinitrate

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Identification
Molecular formula
C6H8N2O8
CAS number
87-33-2
IUPAC name
(6-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) nitrate
State
State

Isosorbide dinitrate is typically a solid at room temperature. As a medication, it is often encountered in solid tablet form, but it can also be formulated into liquid preparations for easier administration.

Melting point (Celsius)
70.00
Melting point (Kelvin)
343.00
Boiling point (Celsius)
205.00
Boiling point (Kelvin)
478.00
General information
Molecular weight
236.14g/mol
Molar mass
236.1390g/mol
Density
1.7300g/cm3
Appearence

Isosorbide dinitrate typically appears as a white, crystalline powder. It is not very soluble in water, which is typical for nitrate esters. Its crystalline structure can make it appear as glossy, reflecting light on its surfaces.

Comment on solubility

Solubility of (6-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) nitrate (C6H8N2O8)

The solubility of the compound (6-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) nitrate is influenced by its intricate molecular structure. Understanding its solubility is essential for various applications, particularly in pharmaceuticals and chemical synthesis. Here are some key points regarding its solubility:

  • Polarity: The presence of multiple functional groups, including nitro and nitrate moieties, often enhances the polar character of the molecule, suggesting a tendency to dissolve in polar solvents.

  • Solvent Compatibility: This compound is likely more soluble in polar solvents (e.g., water, methanol) compared to non-polar solvents (e.g., hexane).

  • Temperature Effects: As with many organic compounds, solubility can increase with temperature; thus, experimentation at varied temperatures may yield different results.

  • Hydrogen Bonding: The potential for hydrogen bonding in this compound may further facilitate solubility in polar environments.

As noted in many solubility studies, "like dissolves like," which means that understanding the compound's functional groups can lead to better predictions of its solubility behavior. Therefore, careful consideration of the solvent choice is paramount when working with (6-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) nitrate.

Interesting facts

Interesting Facts about (6-Nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) Nitrate

This fascinating compound, often recognized for its intricate structure, exhibits a combination of properties that make it a subject of interest in various fields of research. Here are some key points to consider:

  • Structural Complexity: The compound's structure features a hexahydrofuran ring, which is critical in medicinal chemistry as it can influence the biological activity of the compound.
  • Nitrate Group: The presence of the nitrate functional group can enhance the compound's reactivity and bioactivity, making it useful in the development of pharmaceuticals or agrochemicals.
  • Potential Applications: Research suggests that compounds like this may have applications in areas such as explosives, pharmaceuticals, and organic synthesis, illustrating its versatility.
  • Environmental Impact: With increasing focus on environmental sustainability, understanding the behavior and degradation of such complex compounds can help assess their ecological footprint.
  • Analytical Techniques: The study of this compound often involves advanced analytical techniques like NMR, IR spectroscopy, and mass spectrometry to elucidate its structure, revealing insights about its function and reactivity.

Quote from the Field: A prominent chemist once said, "Understanding the complexity of compounds is the key to unlocking their potential." This statement rings especially true for this compound, as its unique structure presents numerous opportunities for research and innovation.

In conclusion, (6-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) nitrate embodies the intricate relationship between structure and function, making it a promising candidate for further study in chemistry and related disciplines.

Synonyms
D-Glucitol, 1,4:3,6-dianhydro-, 2,5-dinitrate
Glucitol, 1,4:3,6-dianhydro-, dinitrate
(6-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) nitrate
1,4:3,6-Dianhydro-D-sorbitol 2,5-dinitrate
BiDil (Salt/Mix)
SORBOPERCUTEN
SORBIDE DINITRATE
Isosorbide-13C6Dinitrate
Isosorbide dinitrate mixture
SCHEMBL309369
SDM No. 40 (Salt/Mix)
SDM No. 50 (Salt/Mix)
CHEMBL250009
SDM-40
MOYKHGMNXAOIAT-UHFFFAOYSA-N
HMS3369G02
BCP28433
component of Dilatrate-SR (Salt/Mix)
DB-056993
1,4:3,6-Dianhydro-D-glucitol 2,5-dinitrate
EN300-11813677
SORBITOL, 1,4:3,6-DIANHYDRO-, DINITRATE
3,6-Dianhydro-D-glucitol dinitrate ; Dilatrate-SR
6-(nitrooxy)-hexahydrofuro[3,2-b]furan-3-yl nitrate
1,4:3,6-Dianhydro-D-glucitol dinitrate; Dilatrate-SR
Isosorbide dinitrate, European Pharmacopoeia (EP) Reference Standard
NSC 80038; NSC-80038; NSC80038; SST-101; Dilatrate SR; Korodil
1219405-83-0