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N-desmethylclozapine hydrochloride

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Identification
Molecular formula
C23H23ClN2O
CAS number
130309-34-5
IUPAC name
6-phenyl-5-[4-(2-piperidin-1-ium-1-ylethoxy)phenyl]-7,8-dihydronaphthalen-2-ol;chloride
State
State

At room temperature, N-desmethylclozapine hydrochloride is a solid.

Melting point (Celsius)
187.00
Melting point (Kelvin)
460.00
Boiling point (Celsius)
298.00
Boiling point (Kelvin)
571.00
General information
Molecular weight
427.98g/mol
Molar mass
427.9820g/mol
Density
1.2000g/cm3
Appearence

N-desmethylclozapine hydrochloride typically appears as a white to off-white crystalline powder. Its fine powder form is characteristic of many pharmaceutical compounds.

Comment on solubility

Solubility of 6-phenyl-5-[4-(2-piperidin-1-ium-1-ylethoxy)phenyl]-7,8-dihydronaphthalen-2-ol;chloride (C23H23ClN2O)

The solubility of the compound 6-phenyl-5-[4-(2-piperidin-1-ium-1-ylethoxy)phenyl]-7,8-dihydronaphthalen-2-ol;chloride is influenced by both its structural characteristics and the presence of the chloride ion. Here are some key points to consider:


  • Polarity: The presence of the ionic piperidinium group suggests that the compound may exhibit a degree of solubility in polar solvents, such as water.
  • Hydrophobic regions: The large naphthalene structure contributes to hydrophobic interactions, which can reduce solubility in aqueous environments but enhance solubility in organic solvents.
  • Chloride ion: The chloride salt form typically increases solubility relative to its free base, thus potentially improving solubility in polar solvents.
  • Temperature dependency: Like many organic compounds, solubility can vary with temperature, typically increasing as temperature rises.

In conclusion, while the overall solubility characteristics of 6-phenyl-5-[4-(2-piperidin-1-ium-1-ylethoxy)phenyl]-7,8-dihydronaphthalen-2-ol;chloride might indicate moderate solubility, empirical testing is recommended to fully understand its behavior in various solvents due to the complex nature of its structure.

Interesting facts

Exploring 6-phenyl-5-[4-(2-piperidin-1-ium-1-ylethoxy)phenyl]-7,8-dihydronaphthalen-2-ol; chloride

This compound, with its complex structure, showcases a fascinating interplay between aromatic and aliphatic components, lending to its unique properties and potential applications. Here are some intriguing aspects to consider:

  • Pharmacological Potential: Due to its piperidine moiety, this compound is likely to exhibit pharmacological properties. Compounds with piperidine rings have been known to act as neurotransmitter modulators, making them interesting candidates for drug development.
  • Diverse Functional Groups: The compound features multiple functional groups, including an ether and a hydroxyl group. This diversity can facilitate various chemical reactions, offering pathways for further modifications and derivatization.
  • Stereochemistry Considerations: The presence of the naphthalene backbone suggests that chirality may play an important role in the activity of this compound. The spatial orientation of its substituents can significantly influence its reactivity and biological interactions.
  • Research Implications: Scientists are constantly exploring similar compounds in the quest to develop new therapeutics. Its structure makes it a valuable target for further study in medicinal chemistry and pharmacology.
  • Clinical Applications: If shown to possess desirable drug-like properties, this compound may find utility in treating various neurological disorders, among other potential therapeutic areas.

As research continues and new insights are gained, compounds like this one remind us of the limitless possibilities within the world of chemistry, where even intricate designs can lead to groundbreaking discoveries and innovations.

Synonyms
2-Naphthol, 7,8-dihydro-6-phenyl-5-(p-(2-piperidinoethoxy)phenyl)-, hydrochloride
10059-68-4
7,8-Dihydro-6-phenyl-5-(p-(2-piperidinoethoxy)phenyl)-2-naphthol hydrochloride