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6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

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Identification
Molecular formula
C12H17NO2
CAS number
76343-85-8
IUPAC name
6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
State
State

At room temperature, 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline is in a solid state.

Melting point (Celsius)
49.00
Melting point (Kelvin)
322.15
Boiling point (Celsius)
315.50
Boiling point (Kelvin)
588.65
General information
Molecular weight
207.27g/mol
Molar mass
207.2650g/mol
Density
1.1661g/cm3
Appearence

6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline is typically found as a solid at room temperature. It can appear as a crystalline powder with a slight off-white to light-yellow color.

Comment on solubility

Solubility of 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

The solubility of 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline can be insightful for various applications in pharmaceuticals and chemistry. This compound, belonging to the isoquinoline family, exhibits specific solubility characteristics influenced by its molecular structure.

Key Factors Affecting Solubility:

  • Polarity: Due to the presence of methoxy groups (-OCH3), the compound may exhibit a degree of polarity, which can enhance its solubility in polar solvents like water and alcohols.
  • Hydrophobic Interactions: The hydrocarbon portions of the molecule can lead to increased lipophilicity, making it more soluble in organic solvents such as chloroform or ether.
  • Temperature: As with many compounds, temperature can significantly affect solubility. Typically, an increase in temperature may lead to greater solubility in organic solvents.

However, it is important to note that the exact solubility values can vary widely based on the solvent used and the experimental conditions. Thus, empirical testing is recommended to determine precise solubility metrics. As a general guideline, one might find the compound:

  1. More soluble in organic solvents due to its hydrophobic regions.
  2. Moderately soluble in polar solvents due to its methoxy substituents.

In summary, while 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline shows intriguing solubility properties, it is vital to assess solubility in the context of the specific application and solvent system in use.

Interesting facts

Interesting Facts about 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

The compound 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline is a fascinating member of the isoquinoline family, which is notable for its diverse applications and activity in various fields. Here are some intriguing facts about this compound:

  • Structural Diversity: This compound features a unique tetrahydroisoquinoline skeleton, making it a versatile platform for synthesizing other bioactive molecules.
  • Natural Occurrence: Isoquinolines, including this one, are often found in various natural products. Their structural motifs are ubiquitous in many plants and can exhibit pharmacological properties.
  • Pharmacological Interest: Compounds of this class are known to demonstrate a range of biological activities, including anti-inflammatory, analgesic, and antitumor effects. Researchers are keen to explore the specific mechanisms of action inherent to this compound.
  • Synthetic Pathways: The synthesis of 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline showcases the beauty of organic chemistry, often involving multi-step reactions that highlight the ingenuity of chemists in constructing complex molecules.
  • Research Potential: Ongoing studies are focused on evaluating its potential use in medicinal chemistry, including its effects on the central nervous system, given the significant role isoquinolines play as neurotransmitter modulators.

“The real substance of organic chemistry lies not in the number of compounds but in the creativity of their synthesis and applications.” The exploration of compounds such as 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline exemplifies this statement, as each synthetic endeavor leads to new possibilities in medicinal research.

Overall, the study of 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline not only enhances our understanding of isoquinoline chemistry but also opens doors to novel therapeutic avenues.

Synonyms
5784-74-7
6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
DTXSID20959384
38520-68-2
DTXCID30207767
837-124-7
Salsolidine
6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline
1,2,3,4-Tetrahydro-6,7-dimethoxy-1-methylisoquinoline
ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-1-METHYL-
1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-isoquinolin
(+/-)-Salsolidine (>90%)
SR-01000842149
(+)-Salsolidine
MFCD00694774
Spectrum_001738
ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-1-METHYL-, HYDROCHLORIDE
SpecPlus_000608
Prestwick0_000532
Prestwick1_000532
Prestwick2_000532
Prestwick3_000532
Spectrum2_001626
Spectrum3_001612
Spectrum4_001664
Spectrum5_000567
Oprea1_776800
Oprea1_807785
BSPBio_000543
BSPBio_003243
KBioGR_002187
KBioSS_002218
DivK1c_006704
SCHEMBL177753
SPECTRUM1504022
SPBio_001691
SPBio_002464
BPBio1_000599
CHEMBL320193
MEGxp0_001951
ACon1_002118
CHEBI:94438
KBio1_001648
KBio2_002218
KBio2_004786
KBio2_007354
KBio3_002463
HMS3561J09
ALBB-028192
FAA78474
CCG-38746
AKOS000268900
AKOS016038394
SB37767
SDCCGMLS-0066785.P001
NCGC00017169-02
NCGC00017169-03
NCGC00017169-04
NCGC00095670-01
NCGC00095670-02
NCGC00095670-03
HY-22385
MS-23136
DB-053116
AB00052924
CS-0042225
NS00094123
E78563
EN300-186699
SR-01000842149-3
SR-01000842149-4
BRD-A75140635-001-03-8
BRD-A75140635-003-03-4
Q27166300
1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-isoquinoline
6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline #
Isoquinoline,1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl
1,2,3,4-Tetrahydro-6,7-dimethoxy-1-methylisoquinoline; 1-Methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline; N-Norcarnegine