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6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Identification
Molecular formula
C11H15NO2
CAS number
6967-29-9
IUPAC name
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
State
State
At room temperature, 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline is generally found in a solid state. This compound is stable under normal temperatures and pressures, and it remains consistent as a crystalline substance.
Melting point (Celsius)
50.00
Melting point (Kelvin)
323.15
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
193.24g/mol
Molar mass
193.2430g/mol
Density
1.1400g/cm3
Appearence

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline is typically found as a crystalline solid. It has a noticeable white or off-white color, depending on the level of purity and the specific form in which it is prepared or stored.

Comment on solubility

Solubility of 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline is a complex organic compound with specific solubility characteristics that are influenced by its unique molecular structure.

When considering its solubility, several factors come into play:

  • Polarity: The presence of methoxy groups generally increases the polarity of the molecule, which can enhance its solubility in polar solvents, such as water and alcohols.
  • Hydrogen Bonding: The potential for hydrogen bonding with water molecules can further improve solubility in aqueous solutions, making it more soluble compared to its non-polar counterparts.
  • Saturation: As a tetrahydroisoquinoline, this compound has multiple saturated bonds, which can limit solubility in non-polar solvents.

It is important to note that specific solubility data may vary:

  • In water: Solubility could be moderate due to the balance between its polar methoxy groups and the overall hydrophobic nature of the isoquinoline skeleton.
  • In organic solvents: Likely more soluble in organic solvents like ethanol or methanol owing to increased interaction with non-polar regions of those solvents.

As a result, predicting the solubility of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline necessitates a consideration of the solvent’s nature and the molecular interactions at play. Understanding these properties is pivotal for applications in medicinal chemistry and drug formulation.

Interesting facts

Interesting Facts about 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline is an intriguing compound that garners interest in the fields of medicinal chemistry and neuroscience due to its potential biological activities. Here are some captivating insights into this compound:

  • Structural Significance: The molecular structure of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline is characterized by a bicyclic framework. This type of structure is commonly found in many biologically active alkaloids.
  • Potential Neuroprotective Effects: Some studies suggest that compounds like this one may exhibit neuroprotective properties, which could be beneficial in safeguarding neurons from damage and degeneration.
  • Role in Medicinal Chemistry: The presence of methoxy groups in the structure may enhance the compound’s lipophilicity, potentially influencing its pharmacokinetic profile and biological activity.
  • Research Interest: Due to its structural analogy to other bioactive compounds, 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline has attracted the attention of researchers looking for new leads in drug discovery, particularly in the treatment of neurological disorders.
  • Alkaloid Classification: Being part of a family of isoquinoline alkaloids, it hints at a wealth of similar compounds that may possess varying degrees of activity, opening avenues for comparative studies.

The exploration of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline not only enhances our understanding of alkaloids but also emphasizes the richness of natural products in the quest for new therapeutic agents. As one researcher aptly noted, "Nature provides a treasure trove of compounds just waiting to be explored for their medicinal potential." This emphasizes the ongoing importance of studying the chemical properties and biological effects of such intriguing molecules in modern science.

Synonyms
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline
Heliamine
ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-
1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinoline
BRN 0158809
DTXSID70169835
5-21-04-00478 (Beilstein Handbook Reference)
DTXCID0092326
814-740-4
1745-07-9
6,7-Dimethoxy-1,2,3,4-tetrahydro-isoquinoline
MFCD00777849
CHEBI:5637
CHEMBL12367
Oprea1_719609
SCHEMBL329913
ISOQUINOLINE,1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-
CEIXWJHURKEBMQ-UHFFFAOYSA-N
6,7-Dimethoxy-1,2,3,4-tetrahydro-isoquinolinehydrochloride
HMS1719L18
6,7-dimethoxytetrahydroisoquinoline
BCP27076
BDBM50593239
STK802586
AKOS000270809
CS-W005976
MB01442
AC-12394
SY041608
DB-043978
DB-350266
6,7-dimethoxy-3,4-dihydro-1H-isoquinoline
6,7-dimethoxy-1,2,3,4tetrahydroisoquinoline
EN300-34125
A11944
C09460
1,2,3,4-Tetrahydro-6,7-dimethoxy-isoquinoline
6,7-dimethoxy-1,2, 3,4-tetrahydroisoquinoline
6,7-dimethoxy-1,2,3,4-tetra hydroisoquinoline
6T-0892
CS-002/03852013
Q27106837
Z57052854
(+/-)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
F9995-0037
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, AldrichCPR
6,7-Dimethoxy-1,2,3,4-tetrahydro-isoquinoline; hydrochloride
InChI=1/C11H15NO2/c1-13-10-5-8-3-4-12-7-9(8)6-11(10)14-2/h5-6,12H,3-4,7H2,1-2H