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Tetrahydropapaverinium chloride

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Identification
Molecular formula
C12H19NO2Cl
CAS number
147-00-6
IUPAC name
6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride
State
State

Tetrahydropapaverinium chloride is a solid at room temperature, commonly appearing in a powdered crystalline form. It is usually handled in dry conditions to prevent contamination or degradation.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
195.00
Boiling point (Kelvin)
468.15
General information
Molecular weight
246.74g/mol
Molar mass
246.7400g/mol
Density
1.2300g/cm3
Appearence

Tetrahydropapaverinium chloride appears as a white crystalline solid. It is often used in its hydrochloride salt form which enhances its solubility in water. The crystalline structure contributes to its application in various chemical research areas.

Comment on solubility

Solubility of 6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium; Chloride

The solubility of 6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium; chloride is a fascinating aspect to explore, especially considering its structural characteristics. Being a quaternary ammonium salt, this compound tends to demonstrate certain distinctive solubility traits.

Key Points Regarding Solubility:

  • Water Solubility: Generally, ionic compounds like chlorides are highly soluble in water due to their ionic nature, which allows for effective hydration of the ions.
  • Solvent Variety: The structural complexity of this compound may also allow it to be soluble in various organic solvents, including:
    • Alcohols (like ethanol)
    • Aromatic hydrocarbons
    • Aqueous solutions with moderate polarity
  • Temperature Influence: The solubility can significantly increase with temperature, making it essential to consider conditions during experiments or applications.
  • Salt Form: As a hydrochloride salt, this compound may exhibit enhanced solubility compared to its non-ionized base due to the stabilization of positive charge by the chloride ion.

In summary, the solubility of 6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium; chloride is promising, especially in polar solvents. However, as with many compounds, actual solubility can vary based on environmental factors. As noted, “Understanding solubility is crucial in chemical applications, influencing everything from reaction rates to product formulations.”

Interesting facts

Interesting Facts About 6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium Chloride

This fascinating compound belongs to the isoquinoline family, known for its interesting structural properties and biological significance. Here are some captivating points to consider:

  • Isoquinoline Derivative: As a derivative of isoquinoline, this compound features a bicyclic structure that is notable for its cyclic nature, which contributes to its interesting chemical behavior and potential biological activity.
  • Pharmacological Potential: Compounds like this one are often studied for their potential therapeutic effects, particularly in the fields of neuroscience and psychiatry. Isoquinolines are known to interact with neurotransmitter systems, which raises intriguing possibilities for medicinal applications.
  • Substituent Significance: The presence of methoxy groups at the 6 and 7 positions can drastically influence the compound's chemical reactivity and biological activity. Methoxy groups are often linked to enhanced lipid solubility, potentially affecting absorption in biological systems.
  • Research Applications: This compound serves as a valuable lead in medicinal chemistry, as researchers aim to derive analogs that can lead to improved efficacy or selectivity in target interactions, especially within the realm of neuropharmacology.
  • Chloride Ion Role: The presence of the chloride ion in its formulation aids in the stability of the compound and can play a crucial role in its solubility and bioavailability.

In summary, 6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium chloride not only showcases interesting structural features but also holds potential implications for research in medicinal chemistry. The unique aspects of its molecular framework and substituents make it a prime candidate for further exploration in understanding its bioactive potential.

Synonyms
103-085-3
6,7-DIMETHOXY-2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
N-Methylheliamine hydrochloride
N-Methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
ISOQUINOLINE, N-METHYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-, HYDROCHLORIDE
Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, hydrochloride