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6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Identification
Molecular formula
C12H17NO2
CAS number
33385-61-0
IUPAC name
6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline
State
State

At room temperature, this compound is typically a solid. It is likely stable under normal conditions but should be handled with care to avoid degradation or reaction with environmental factors such as moisture.

Melting point (Celsius)
45.00
Melting point (Kelvin)
318.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
191.25g/mol
Molar mass
191.2520g/mol
Density
1.1320g/cm3
Appearence

The compound typically appears as a white to light yellow crystalline solid. Its purity and processing conditions can slightly alter the exact shade and texture of the crystals.

Comment on solubility

Solubility of 6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline

When considering the solubility of 6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline, several factors come into play:

  • Polarity: The presence of two methoxy groups (-OCH3) enhances polarity, potentially increasing solubility in polar solvents such as water.
  • Hydrophobic Character: The isoquinoline structure contributes a degree of hydrophobicity, which may limit solubility in highly polar environments.
  • Solvent Interaction: Predictions regarding solubility can be made based on solubility in common organic solvents like methanol, ethanol, and DMSO.

It is often noted that:

"Compounds with both hydrophilic and hydrophobic regions can exhibit variable solubility based on solvent choice."

Experimental data points to solubility in organic solvents, suggesting that 6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline is likely to be more soluble in non-polar to moderately polar solvents while facing challenges in water, making it important to consider these factors in practical applications.

Interesting facts

Interesting Facts about 6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline

6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline is a fascinating chemical compound that belongs to a class of compounds known as isoquinolines. This particular isoquinoline derivative holds significant interest in various fields, especially in medicinal and organic chemistry. Here are some notable points:

  • Natural Product Potential: Isoquinolines are often found in numerous natural products and alkaloids, which can exhibit diverse biological activities. This compound's structure suggests potential pharmacological properties, making it a subject of interest in drug discovery.
  • Synthetic Versatility: The synthesis of 6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline provides an excellent example of complex organic synthesis techniques. Understanding the reaction pathways and mechanisms involved enhances a chemist's toolkit for creating similar compounds.
  • Biological Interest: Compounds containing isoquinoline structures have been studied for their effects on the central nervous system. Some derivatives have shown promise as potential treatments for neurological disorders.
  • Research Applications: This isoquinoline derivative can serve as a precursor in the synthesis of various bioactive molecules, aiding in the exploration of new medicinal agents.
  • Structure-Activity Relationship (SAR): The presence of methoxy groups in the structure may influence the compound's reactivity and biological activity, offering chemists avenues to explore structure-activity relationships further.

In summary, 6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline displays a rich tapestry of chemical properties and potential applications. Its study not only contributes to our understanding of isoquinoline chemistry but also opens up exciting possibilities in medicinal chemistry and drug development. As a compound that bridges organic synthesis and biological activity, it remains an intriguing topic for both researchers and students alike.

Synonyms
6,7-DIMETHOXY-2-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
683-442-2
O-Methylcorypalline
N-Methylheliamine
16620-96-5
6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline
ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL-
1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinoline
UK294JA983
NSC-280726
N-Methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CHEMBL555787
BRN 0011592
N-Methyl-corypalline
NSC280726
5-21-04-00479 (Beilstein Handbook Reference)
UNII-UK294JA983
SCHEMBL5525085
CHEMBL1196025
SCHEMBL30634713
DTXSID90168082
Isoquinoline,1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-
CHEBI:192040
TXPPKWZEHFNZOE-UHFFFAOYSA-N
BDBM50014648
MFCD00195543
AKOS015872575
NSC 280726
SY472844
DS-011314
ST50405883
3,4-dihydro-6,7-dimethoxy-2-methyl-isoquinoline
AE-508/40920516
1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-Isoquinoline
1,2,3,4-Tetrahydroisoquinoline, 6,7-dimethoxy-N-methyl-
6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline #
6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline; hydrobromide (o-methylcorypalline)
InChI=1/C12H17NO2/c1-13-5-4-9-6-11(14-2)12(15-3)7-10(9)8-13/h6-7H,4-5,8H2,1-3H