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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium;chloride
State
State

Colchicine is typically a solid at room temperature. It is stable under normal conditions but should be stored away from light and moisture to maintain its stability and effectiveness.

Melting point (Celsius)
255.00
Melting point (Kelvin)
528.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
399.44g/mol
Molar mass
399.4400g/mol
Density
1.6600g/cm3
Appearence

Colchicine typically appears as a pale yellow powder or crystalline solid. It is often supplied in a fine, granular form and is insoluble in cold water but soluble in alcohol and chloroform.

Comment on solubility

Solubility of 6,7-Dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium Chloride

The solubility of 6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium chloride is influenced by several key factors, making it crucial for various applications in medicinal chemistry and research. Here are some insights into the solubility of this compound:

  • Solvent Interaction: This compound generally exhibits better solubility in polar solvents due to its ionic nature, making water one of the most effective solvents.
  • Temperature Dependence: As is common with many organic compounds, solubility may increase with rising temperature. This reflects the typical behavior of solutes dissolving better at elevated temperatures.
  • pH Sensitivity: Being a quaternary ammonium compound, its solubility may vary with changes in pH, which can affect the ionization state and, consequently, the solubility profile.

It's essential to note that the presence of the chloride ion may also enhance solubility due to its ionic interactions. Therefore, when considering the practical applications of 6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium chloride, careful evaluation of its solubility characteristics in various solvents and conditions is paramount.

In summary, understanding the solubility of this compound can significantly impact its utility in pharmaceutical formulations and chemical applications:

  1. Optimal solvent selection is critical.
  2. Temperature variation can enhance solubilization.
  3. pH adjustments may be necessary for targeted solubility outcomes.
Interesting facts

Interesting Facts about 6,7-Dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium; Chloride

6,7-Dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium chloride, often abbreviated as DMIQ, is a fascinating compound that draws interest due to its unique structure and potential applications in medicinal chemistry. Here are some engaging insights:

  • Isoquinoline Derivative: DMIQ belongs to the isoquinoline family, a group known for their diverse biological activities. Isoquinolines are found in many natural products, thus showing the importance of this structural framework in pharmacology.
  • Biological Activity: Compounds like DMIQ have been studied for their potential in treating neurological disorders. Their interactions with neurotransmitter receptors could pave the way for new therapeutic agents.
  • Research Applications: There's an increasing interest in the use of DMIQ in the field of organic synthesis. Its complex structure allows for the creation of various derivatives that can be valuable in developing new drugs.
  • Structure-Activity Relationship: The introduction of methoxy groups in the 6 and 7 positions is key; these modifications can enhance activity and selectivity towards specific biological targets, making DMIQ a point of study for chemists.
  • Major Role in Syntheses: The dihydroisoquinoline scaffold is often utilized in the synthesis of more complex natural products, serving as a versatile precursor in the field of synthetic organic chemistry.

As a compound derived from a rich chemical lineage, 6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium chloride exemplifies the intricate relationship between chemistry and biology. Its potential applications in pharmaceuticals invite further research and exploration, underlining the significance of each novel compound in the quest for innovative solutions in medicine.

Synonyms
Lodal
553-28-6
6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium chloride
EINECS 209-037-9
NSC 33525
3,4-Dihydro-6,7-dimethoxy-2-methylisoquinolinium chloride
ISOQUINOLINIUM, 3,4-DIHYDRO-6,7-DIMETHOXY-2-METHYL-, CHLORIDE
DTXSID60970619
SNESGMZASZVGNN-UHFFFAOYSA-M
NSC33525
NSC-33525
NS00044047
Isoquinolinium,4-dihydro-6,7-dimethoxy-2-methyl-, chloride