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Berberine

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Identification
Molecular formula
C20H18NO4
CAS number
2086-83-1
IUPAC name
6,7-dimethoxy-2,2-dimethyl-3,4-dihydro-1H-isoquinolin-2-ium
State
State

At room temperature, berberine is typically in a solid state, often found as a yellow powdery substance.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
244.00
Boiling point (Kelvin)
517.15
General information
Molecular weight
321.36g/mol
Molar mass
321.3620g/mol
Density
1.2300g/cm3
Appearence

Berberine is a bright yellow compound that is often used as a dye. It is typically seen as a yellow crystalline powder in its pure form.

Comment on solubility

Solubility of 6,7-Dimethoxy-2,2-dimethyl-3,4-dihydro-1H-isoquinolin-2-ium

The solubility of 6,7-dimethoxy-2,2-dimethyl-3,4-dihydro-1H-isoquinolin-2-ium can be quite significant due to its unique structural features. Here are some essential points to consider:

  • Polarity: The presence of methoxy groups enhances the molecule's polarity, which may facilitate its solubility in polar solvents like water and alcohols.
  • Hydrogen Bonding: The functional groups are prone to forming hydrogen bonds, making the compound more soluble in solvents that can engage in such interactions.
  • Temperature Dependency: Like many organic compounds, the solubility of this isoquinolin-2-ium may increase with temperature, allowing for better dissolution in heated solvents.
  • pH Considerations: As an ionizable compound, its solubility may change significantly with the pH of the solution, which can alter the ionization state and hence the solubility profile.

In summary, the solubility of 6,7-dimethoxy-2,2-dimethyl-3,4-dihydro-1H-isoquinolin-2-ium can be effectively influenced by various factors, including polarity, the presence of hydrogen bonding sites, temperature, and solution pH. Understanding these aspects can be crucial for effective applications and formulations that involve this compound.

Interesting facts

Interesting Facts about 6,7-Dimethoxy-2,2-dimethyl-3,4-dihydro-1H-isoquinolin-2-ium

6,7-dimethoxy-2,2-dimethyl-3,4-dihydro-1H-isoquinolin-2-ium is a fascinating compound belonging to the class of isoquinolines, which are derived from natural alkaloids. Here are some key features that make this compound particularly interesting:

  • Structural Complexity: The isoquinoline framework offers a unique fusion of aromatic and non-aromatic rings, leading to versatile chemical reactivity.
  • Biological Significance: Compounds in the isoquinoline family are known for their wide range of biological activities, including antimicrobial, antitumor, and anti-inflammatory effects. This particular compound may also show therapeutic potential worth exploring.
  • Synthetic Variability: The presence of multiple methoxy groups and dimethyl substitutions allows for a variety of synthetic pathways, making it an interesting target for chemists looking to develop new derivatives.
  • Electrochemical Properties: The cationic nature of this compound makes it susceptible to electrochemical studies, which can highlight its behavior in different chemical environments.

Moreover, the study of such compounds continues to be a crucial part of medicinal chemistry and drug discovery. Researchers often quote the importance of isoquinolines in pharmacology, stating:

"The isoquinoline structure remains central to the development of novel therapeutics." – Chemist's Review

In conclusion, 6,7-dimethoxy-2,2-dimethyl-3,4-dihydro-1H-isoquinolin-2-ium is not just another organic compound; it represents a dynamic intersection of chemistry, biology, and medicine. The exploration of its properties and potential applications constitutes an exciting field of study for chemists.

Synonyms
6,7-dimethoxy-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium
CHEMBL1624599
STL581419
AKOS040893916
NCGC00246223-01