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Noscapine

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Identification
Molecular formula
C22H23NO7
CAS number
128-62-1
IUPAC name
6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one
State
State

Noscapine is typically a solid at room temperature. It is used medicinally and is found in a crystalline form in pharmaceutical preparations.

Melting point (Celsius)
174.00
Melting point (Kelvin)
447.20
Boiling point (Celsius)
315.60
Boiling point (Kelvin)
588.80
General information
Molecular weight
413.42g/mol
Molar mass
413.4240g/mol
Density
1.3420g/cm3
Appearence

Noscapine is typically a white, crystalline powder. It appears colorless when in its pure form.

Comment on solubility

Solubility of 6,7-Dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one

The solubility of the compound C22H23NO7, known as 6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one, can be intriguing to explore. This compound’s solubility can be affected by various factors, and understanding these helps in predicting its behavior in different environments:

  • Polarity: The presence of methoxy groups and various functional groups influences the polarity of the molecule, likely enhancing its solubility in polar solvents.
  • Solvent Compatibility: It may exhibit greater solubility in organic solvents such as ethanol or methanol, while its solubility in water could be relatively lower due to hydrophobic interactions.
  • Temperature Effects: Increasing the temperature generally enhances solubility. Therefore, higher temperatures may improve the dissolution rate of this compound in suitable solvents.
  • pH Levels: The ionization of certain functional groups can vary with pH, influencing solubility. In particular, different pH environments could lead to increased dissolution in basic or acidic solutions.

In summary, while definitive solubility data may not be readily available, the factors outlined above provide a strong framework for understanding how 6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one can interact with different solvation systems. Exploring these nuances is critical for applications in pharmaceutical formulations or material science.

Interesting facts

Interesting Facts about 6,7-Dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one

This compound is a fascinating example of the diversity found within organic chemistry, particularly in the realm of bioactive molecules. Here are some noteworthy points about this intricate structure:

  • Complexity of Structure: The compound features multiple functional groups and ring systems, highlighting the intricate nature of organic synthesis. Its design showcases a blend of isoquinoline and dioxole moieties, which are of significant interest in pharmaceutical research.
  • Potential Biological Activity: Compounds with similar structures have historically exhibited various biological activities, including antitumor, antibacterial, and anti-inflammatory properties. This suggests that it may also possess noteworthy medicinal potential.
  • Derivatives and Modifications: The various methoxy groups present can facilitate diverse reactivity, offering opportunities for the development of analogs that may enhance desired biological activities while minimizing side effects. This is often a key strategy in drug discovery.
  • Analytical Techniques: The study of such compounds relies heavily on advanced analytical techniques such as NMR spectroscopy and mass spectrometry. These techniques allow chemists to understand the compound's behavior and interactions at a molecular level.
  • Applications in Research: Researchers are continuously investigating derivatives of complex compounds like this one for use in therapeutic applications, including drug development and targeted therapies.

As we explore the depths of organic compounds like 6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one, it becomes clear that each molecule tells a unique story in the landscape of chemistry. Embracing the complexity of such compounds is essential for paving the way for breakthroughs in pharmacology and materials science.

Synonyms
10421-76-8
Gnoscopine
Nascopine
6,7-Dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3h-isobenzofuran-1-one
dl-Narcotine
alpha-Gnoscopine
6,7-dimethoxy-3-{4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl}-1,3-dihydro-2-benzofuran-1-one
6035-40-1
(S,R)-Noscapine
6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one
6,7-dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one
Noscapine base
Narcotine alkaloid
1(3H)-Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-
(-)-.alpha.-Norcotine
a-Gnoscopine
1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-
(.+-.)-Narcotine
(+/-) a-Narcotine
(+/-)-alpha-Narcotine
(.+-.)-alpha-narcotine
MLS000104989
CHEMBL402487
SCHEMBL2494164
ACon1_001760
DTXSID20859254
AKNNEGZIBPJZJG-UHFFFAOYSA-N
CHEBI:110185
HMS2268L14
[S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-Isobenzofuranone
1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-
6,7-Dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one, (S-(R*,S*))- #
KAA42176
Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-
SYB68057
AKOS000264931
AKOS021982592
NCGC00015757-04
NCGC00015757-05
NCGC00015757-07
NCGC00015757-09
6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one
SMR000054918
DB-041903
CS-0206804
NS00000477
AB00642499_13
Q415619
SR-01000003078
SR-01000003078-2
BRD-A77907596-001-01-9
1-Alpha-2-methyl-8-methoxy-6,7-methylenedioxy-1-(6,7-dimethoxy-3-phthalidyl)-1,2,3,4-tetrahydroisoquinoline
6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone