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Noscapine

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Identification
Molecular formula
C22H23NO7
CAS number
128-62-1
IUPAC name
6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one
State
State

At room temperature, noscapine is generally found as a solid.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
288.70
Boiling point (Kelvin)
561.85
General information
Molecular weight
413.44g/mol
Molar mass
413.4360g/mol
Density
1.3180g/cm3
Appearence

Noscapine typically appears as white crystalline powder or colorless crystals.

Comment on solubility

Solubility Insights of 6,7-Dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one

The solubility of any compound is a crucial factor that influences its applications, particularly in pharmaceuticals and chemical processes. For the compound with the name 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one and the formula C22H23NO7, several aspects must be considered:

  • Nature of the compound: Given its complex structure and the presence of multiple methoxy (-OCH3) and dioxole functional groups, the compound may exhibit moderate to high solubility in organic solvents but lower solubility in aqueous media.
  • Polarity: The inclusion of methoxy groups typically enhances solubility in polar solvents due to their ability to form hydrogen bonds. Therefore, this compound is likely to be more soluble in alcohols and acetone.
  • Hydrogen-bonding capabilities: The compounds that can engage in hydrogen bonding usually have improved solubility in solvents like water, which could suggest that the presence of dioxole might favor solubility in polar environments.
  • Stability: The ability for the compound to remain stable in solution can also affect its practical solubility. Compounds that degrade or decompose upon dissolution would show varying and unpredictable solubility patterns.

In summary, while the 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one compound likely exhibits notable solubility characteristics in certain organic solvents, its aqueous solubility may be limited. Understanding the balance of polarity, functional groups, and hydrogen-bonding potential is essential in predicting its behavior in various solutions.

Interesting facts

Exploring 6,7-Dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one

This fascinating compound, often referred to for its complex structure and unique properties, falls into the category of isoquinoline derivatives, which are known for their pharmacological significance. One of the key reasons scientists are interested in this compound is its potential application in medicinal chemistry.

Key Features:

  • Structural Diversity: The inclusion of multiple functional groups such as methoxy, isobenzofuran, and dioxolo structures contributes to its rich chemical behavior and the potential for various interactions.
  • Biological Activity: Compounds of this nature often exhibit a range of biological activities, including anti-inflammatory, antimicrobial, and antitumor properties, making them intriguing for drug discovery.
  • Synthetic Challenges: The complexity of synthesizing such a compound can pose significant challenges in the laboratory, offering a great learning experience for chemistry students and researchers alike.

Furthermore, the unique arrangement of atoms in this compound allows it to interact with biological targets in ways that simpler structures cannot. For instance, studies have suggested that variations in the dioxolo and isoquinoline moieties influence the binding affinity to specific receptors in the body.

As noted by chemists, "The beauty of organic synthesis often lies in the intricate details of each component and how they come together to create structures that are not only fascinating but also hold potential for therapeutic applications." This sentiment resonates deeply within the study of such complex molecules.

In summary, 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one serves as an excellent exemplification of how intricate organic chemistry can lead to compounds with valuable applications in the field of medicine.

Synonyms
(+/-)-beta-Hydrastine
1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-
6,7-Dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one
1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (S-(R*,S*))-
6,7-dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one
73554-66-2
(-)-beta-Hydrastine;(1R,9S)-beta-Hydrastine
60594-55-0
(-)-Hydrastin
l-.beta.-Hydrastine
Oprea1_165991
Oprea1_763992
MLS001210424
MEGxp0_001472
SCHEMBL1649584
CHEMBL1256868
DTXSID40859216
JZUTXVTYJDCMDU-UHFFFAOYSA-N
HMS1679F22
HMS2847F12
HMS3373A08
NCGC00015521-02
NCGC00015521-03
NCGC00015521-04
NCGC00015521-05
NCGC00015521-06
NCGC00015521-07
NCGC00017332-03
NCGC00017332-04
NCGC00091048-01
NCGC00091048-02
NCGC00091048-03
NCGC00091048-04
NCGC00091048-05
NCGC00093981-01
NCGC00093981-02
NCGC00093981-03
NCGC00093981-04
SMR000518978
DB-041388
NS00002865
F85194
Q978050
SR-01000316445
SR-01000316445-1
[S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone
1(3H)-isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-
6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone
6,7-Dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one