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Papaverine hydrochloride

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Identification
Molecular formula
C20H22ClNO4
CAS number
61-25-6
IUPAC name
6,7-dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride
State
State
Papaverine hydrochloride is typically found as a solid at room temperature. It remains stable under normal conditions and is soluble in water and ethanol.
Melting point (Celsius)
163.00
Melting point (Kelvin)
436.15
Boiling point (Celsius)
336.00
Boiling point (Kelvin)
609.15
General information
Molecular weight
378.86g/mol
Molar mass
378.8580g/mol
Density
1.0900g/cm3
Appearence

Papaverine hydrochloride appears as a white to off-white crystalline powder. It is highly sensitive to light and moisture, and its solid form should be stored in airtight containers to prevent degradation. Upon exposure to light, the compound may exhibit slight discoloration without affecting its efficacy.

Comment on solubility

Solubility of 6,7-dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride

The solubility of 6,7-dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride can be intriguing due to its unique chemical structure. Here’s what we know:

  • Solvent Compatibility: This compound is generally expected to be soluble in polar solvents such as water, alcohols, and possibly some organic solvents due to the presence of the chloride ion and the quaternary ammonium structure.
  • Temperature Dependence: Like many salts, the solubility may increase with temperature, making it more likely to dissolve at elevated temperatures.
  • pH Sensitivity: The solubility could be influenced by the pH of the solution; higher acidity might enhance solubility, while basic conditions could precipitate it.
  • Interactions: The specific solvation interactions between the solvent and the quaternary ammonium group may play a critical role in solubility behavior.

In summary, while precise quantitative solubility data might not always be readily available, it is clear that understanding the solubility dynamics of this compound can expand our insight into its potential applications and reactivity.

Interesting facts

Interesting Facts about 6,7-dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride

The fascinating compound 6,7-dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride holds a unique place in the realm of organic chemistry and pharmacology. As a derivative of isoquinoline, it is noteworthy for several reasons:

  • Cognitive Impact: Compounds in the isoquinoline family have been studied for their potential nootropic (cognitive enhancing) effects. This could make them interesting candidates for further research into cognitive health.
  • Natural Occurrence: Isoquinolines are often found in medicinal plants, suggesting a historical context of their use in traditional medicine systems.
  • Pharmacological Potential: Many compounds related to this tetrahydroisoquinoline structure show promise in the treatment of neurodegenerative diseases, due to their interactions with neurotransmitter systems.
  • Multifunctionality: The presence of multiple methoxy groups can influence both the solubility and biological activity of the compound, often enhancing its pharmacokinetic profile.

Scientific inquiries often reveal that chemical compounds like 6,7-dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride could lead the way to innovations in drug design. As the noted chemist Robert H. Grubbs once said, "Chemistry is the science of the bonds that connect us." Indeed, exploring the bonds and structures of this compound might pave the path for new therapeutic agents in the future.

Furthermore, the research surrounding such compounds often intersects with fields like biochemistry and molecular biology, underlining the complexity and interconnectedness of scientific disciplines.

Synonyms
NSC 36661
1,2,3,4-Tetrahydro-6,7-dimethoxy-3-methylisoquinoline hydrochloride
6,7-dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride
ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-3-METHYL-, HYDROCHLORIDE
SCHEMBL5708777