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Lappaconitine

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Identification
Molecular formula
C26H38ClNO5
CAS number
60218-35-1
IUPAC name
6,7-dimethoxy-3-methyl-3,4-dihydroisoquinolin-2-ium;chloride
State
State

At room temperature, lappaconitine hydrochloride is a solid, specifically a crystalline powder.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.15
Boiling point (Celsius)
265.00
Boiling point (Kelvin)
538.15
General information
Molecular weight
586.07g/mol
Molar mass
586.0700g/mol
Density
1.3000g/cm3
Appearence

Lappaconitine hydrochloride appears as a white or almost white crystalline powder. It is typically odorless and has a bitter taste.

Comment on solubility

Solubility of 6,7-dimethoxy-3-methyl-3,4-dihydroisoquinolin-2-ium;chloride

The solubility of 6,7-dimethoxy-3-methyl-3,4-dihydroisoquinolin-2-ium;chloride can be characterized by several key factors:

  • Polarity: This compound possesses polar functional groups, which typically enhance solubility in polar solvents such as water.
  • Salt Formation: As a chloride salt, it is likely to be more soluble in aqueous solutions due to ionic interactions.
  • Temperature Dependency: The solubility may increase with temperature, a common characteristic of many organic compounds.

In general, it is important to note that solubility can be influenced by several factors, including:

  1. pH of the solution: Changes in pH may affect the ionization and, consequently, the solubility of the compound.
  2. Presence of other solutes: The solubility can be impacted by the nature and concentration of other substances in the solution.
  3. Solvent choice: Non-polar solvents may not solvate the compound efficiently, leading to lower solubility.

In conclusion, while the specific solubility of 6,7-dimethoxy-3-methyl-3,4-dihydroisoquinolin-2-ium;chloride can be variable, it is predominantly soluble in polar solvents owing to its ionic nature and molecular characteristics. It would be advisable to conduct empirical tests to determine precise solubility values under varied conditions.

Interesting facts

Interesting Facts About 6,7-Dimethoxy-3-methyl-3,4-dihydroisoquinolin-2-ium Chloride

This fascinating compound, known as 6,7-dimethoxy-3-methyl-3,4-dihydroisoquinolin-2-ium chloride, is part of a unique class of organic molecules that exhibit notable pharmacological properties. Here are some engaging aspects of this compound:

  • Structural Significance: The compound exhibits a complex isoquinoline scaffold, which is crucial in many biological systems. Isoquinolines are known for their presence in numerous natural alkaloids and thus provide interesting avenues for medicinal chemistry.
  • Biological Potential: Compounds similar to this one have been investigated for their neuroprotective and antioxidant properties. Research has suggested that isoquinoline derivatives may play roles in neurodegenerative disease treatment, showing potential in enhancing neuronal health.
  • Pharmacophore Exploration: The inclusion of methoxy groups at positions 6 and 7 is significant as they can profoundly influence the biological activity and solubility profiles of the molecule. These modifications are often tailored to enhance receptor interactions.
  • Chloride Ion Role: The chloride counterion is essential for maintaining charge balance in the ionic compound. Furthermore, chloride ions can influence the compound's solubility and reactivity, making them pivotal for the compound's overall functionality.
  • Research Interest: Ongoing studies focus on the modulation of biological activities through structural changes, providing insights into developing new therapeutic agents. The adaptability of such compounds in drug formulation is crucial as scientists seek to optimize their efficacy.

In summary, the exploration of 6,7-dimethoxy-3-methyl-3,4-dihydroisoquinolin-2-ium chloride presents an exciting opportunity for research in organic and medicinal chemistry. Its intriguing properties and potential applications make it a valuable subject of study for future drug development.

Synonyms
NSC 36394
3,4-Dihydro-6,7-dimethoxy-3-methylisoquinoline hydrochloride
ISOQUINOLINE, 3,4-DIHYDRO-6,7-DIMETHOXY-3-METHYL-, HYDROCHLORIDE