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6,7-Dimethoxyquinolin-4-amine hydrochloride hydrate

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Identification
Molecular formula
C11H14ClN3O2
CAS number
22155-21-5
IUPAC name
6,7-dimethoxyquinolin-4-amine;hydrate;hydrochloride
State
State

At room temperature, 6,7-Dimethoxyquinolin-4-amine hydrochloride hydrate is in a solid state. It is typically handled as a powder or crystalline solid.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
485.00
Boiling point (Kelvin)
758.15
General information
Molecular weight
266.70g/mol
Molar mass
266.7330g/mol
Density
1.2800g/cm3
Appearence

6,7-Dimethoxyquinolin-4-amine hydrochloride hydrate appears as an off-white to pale yellow solid. It may also present as a crystalline powder depending on the crystallization process and the grade of the material.

Comment on solubility

Solubility of 6,7-Dimethoxyquinolin-4-amine Hydrochloride Hydrate

The solubility of 6,7-dimethoxyquinolin-4-amine;hydrate;hydrochloride in various solvents presents an interesting profile. Being a hydrochloride, it typically exhibits improved solubility in polar solvents due to the presence of the ionic hydrochloride group. Here are some key points to consider regarding its solubility:

  • Water: Generally, hydrochlorides are more soluble in water compared to their free-base counterparts, so one could anticipate that 6,7-dimethoxyquinolin-4-amine hydrochloride would show reasonable solubility.
  • Organic Solvents: The solubility in organic solvents is often lower and may vary significantly, depending on the solvent's polarity. For instance, it may have limited solubility in less polar solvents.
  • pH Dependency: The pH of the solution can also influence solubility; a more acidic environment could enhance solubility further.
  • Temperature Effect: As with many compounds, solubility can increase with rising temperatures, making it important for applications that involve heat.

To summarize, the solubility characteristics of 6,7-dimethoxyquinolin-4-amine hydrochloride are influenced by its ionic nature, and it is essential to consider the choice of solvent and environmental conditions when determining its solubility in practical applications. As expressed in various studies, “The solubility landscape is critical in optimizing formulations and ensuring effective delivery of active substances.

Interesting facts

Interesting Facts About 6,7-Dimethoxyquinolin-4-amine;hydrate;hydrochloride

6,7-Dimethoxyquinolin-4-amine;hydrate;hydrochloride is a fascinating compound with a variety of applications and characteristics that make it a subject of interest in the field of chemistry. Below, we'll explore some of its noteworthy aspects:

  • Pharmaceutical Potential: This compound is often studied for its potential therapeutic effects. Compounds similar to quinoline derivatives have been explored for their role in treating various diseases, including cancers and infectious diseases.
  • Structural Versatility: The unique structure of this compound, featuring both methoxy and amine functional groups, provides it with a range of possible reactivity and interactions. This versatility can lead to the synthesis of new derivatives that may have enhanced biological properties.
  • Hydrochloride Form: The presence of the hydrochloride salt form increases solubility in water, making it easier for pharmacological testing and applications in drug formulation.
  • Research Opportunities: Ongoing research into quinoline derivatives reveals their potential as catalysts or ligands in various chemical reactions. Scientists often delve into the synthesis of these compounds to uncover new pathways in organic chemistry.
  • Historic Significance: Compounds within the quinoline family have been used historically in dyes and as antimalarial agents, showcasing the broad impact of chemistry on both industry and public health.

In summary, 6,7-Dimethoxyquinolin-4-amine;hydrate;hydrochloride exemplifies the intersection of medicinal chemistry and organic synthesis, offering exciting prospects for both academic research and practical applications. As with many such compounds, understanding its behavior and interactions can pave the way for innovative developments in pharmaceutical science.

Synonyms
AMIQUINSIN HYDROCHLORIDE
7125-70-4
Amiquinsin HCl
Amiquinsin hydrochloride [USAN]
UNII-EZ270U8Z9W
4-Amino-6,7-dimethoxyquinoline hydrochloride monohydrate
EZ270U8Z9W
Amiquinsin hydrochlorid-1-wasser
Amiquinsin hydrochloride (USAN)
U-935
4-Quinolinamine, 6,7-dimethoxy-, monohydrochloride, monohydrate
DTXSID50221425
4-amino-6,7-dimethoxyquinoline hydrochloride, monohydrate
DTXCID50143916
Amiquinsin Hydrochloride Monohydrate
U 935
SCHEMBL122139
amiquinsin hydrochloride hydrate
D02912
6,7-dimethoxyquinolin-4-amine;hydrate;hydrochloride
Q27277444